Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Investigation of Demand Diversity and Appropriate New Generation Entry into Electricity Market Simulation Tools. The power industry is currently facing a great challenge in providing
better market operation and management following recent devastating blackouts in North America, UK and Italy. This project aims at investigating major mechanisms of market simulation techniques including impacts from load diversity and approaches to defining appropriate new generation entry into the market. From th ....Investigation of Demand Diversity and Appropriate New Generation Entry into Electricity Market Simulation Tools. The power industry is currently facing a great challenge in providing
better market operation and management following recent devastating blackouts in North America, UK and Italy. This project aims at investigating major mechanisms of market simulation techniques including impacts from load diversity and approaches to defining appropriate new generation entry into the market. From the outcome of this project the National Electricity Market will be able to manage the uncertainties of load diversity (one of the most common blackout causes), and efficiently minimise risk associated with decisions on new generation entry to enhance electricity supply infrastructure.
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Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the ....ARC Communications Research Network. Building on a strong platform of existing research excellence, the Aim of the Network is to facilitate nation-wide collaborative research, promoting four intersecting research Themes: Mobile and Wireless Communications, Rural Communications, Broadband and Optical Networks, and Fundamentals of Emerging Media. Each Theme is formulated to drive multidisciplinary, innovative research as well as inspire new collaborative initiatives. Four Programs encapsulate the core activities of the Network: Researcher Mobility, Workshops and Conferences, Postgraduate Education, and Knowledge Management Systems. The Network is expected to add significant value to pre-existing investments and raise the profile of Australian telecommunications research.Read moreRead less
Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of ....Stability Analysis of Power System with Massive Power Electronic Devices. The decarbonization of Australia's power systems is to integrate massive renewable energy sources which are interfaced with many power electronic devices (PEDs). The fast and complex dynamics of PEDs have significantly changed the nature of the power system, which limits the applicability of existing tools and methods to assess its stability. The goal of this project is to gain a comprehensive insight into the stability of a futuristic power system with high penetration of PEDs. The intended outcomes will be a model and data jointly driven methodology for high-efficient and real-time stability assessment. The methodology developed in this project will support Australia's transition to a stable, secure, and low-carbon power grid.Read moreRead less