Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100044
Funder
Australian Research Council
Funding Amount
$860,000.00
Summary
Cryogenic Experimental Laboratory for Low-background Australian Research. This project aims to build an open-access cryogenic facility in the only deep-underground physics laboratory in the southern hemisphere. This facility, called the Cryogenic Experimental Laboratory for Low-background Australian Research (CELLAR), will provide extreme shielding from sources of noise, enabling ultra-precise experiments for fundamental science and emerging applications. The expected outcomes include a deeper u ....Cryogenic Experimental Laboratory for Low-background Australian Research. This project aims to build an open-access cryogenic facility in the only deep-underground physics laboratory in the southern hemisphere. This facility, called the Cryogenic Experimental Laboratory for Low-background Australian Research (CELLAR), will provide extreme shielding from sources of noise, enabling ultra-precise experiments for fundamental science and emerging applications. The expected outcomes include a deeper understanding of astrophysics, alongside technological advances in emerging quantum technologies. CELLAR’s unique capabilities will attract strong international collaborations with multidisciplinary teams, educating the next generation of scientists and advancing the growth of Australian high-technology industries.Read moreRead less
CCC method: new applications to electron scattering from atoms and molecules. Achievement of the stated aims will be of enormous benefit to industry
and laboratory research because at the present time no reliably accurate
models exist for the range of the required scattering parameters. The
modelling work will result in development of new software packages for
supercomputers and will provide training for research associates, PhD
and Honours students in an area where Australian theorists are ....CCC method: new applications to electron scattering from atoms and molecules. Achievement of the stated aims will be of enormous benefit to industry
and laboratory research because at the present time no reliably accurate
models exist for the range of the required scattering parameters. The
modelling work will result in development of new software packages for
supercomputers and will provide training for research associates, PhD
and Honours students in an area where Australian theorists are
preeminent.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238631
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of ato ....Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of atoms and molecules will be enabled, including the dynamics of near-threshold processes, the formation of transient states and the examination of processes such as rotational excitation and dissociative attachment in molecules - important in a number of gas-discharge based devices.
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A complete computational approach to electron-atom collisions. Our research contributes to multidisciplinary efforts to improve the efficiency and reduce the toxicity of lighting systems, which has far-reaching implications for environmental sustainability. It will also facilitate significant improvements in the accuracy of astrophysical and artificial plasma modelling, as well as providing insight into many processes fundamental to nanotechnology research. The research project will further enha ....A complete computational approach to electron-atom collisions. Our research contributes to multidisciplinary efforts to improve the efficiency and reduce the toxicity of lighting systems, which has far-reaching implications for environmental sustainability. It will also facilitate significant improvements in the accuracy of astrophysical and artificial plasma modelling, as well as providing insight into many processes fundamental to nanotechnology research. The research project will further enhance our reputation in an area where Australian theorists are preeminent, and the research training will produce PhD graduates with a high-level ability in numerical modelling using supercomputers. Such skills are essential in many defense, mining and technological applications of national priority.Read moreRead less
Electronic and atomic collision theory. Recently there has been rapid progress in the field of electronic and atomic collisions. Consequently, many new problems have emerged of interest to science and industry. The proposed collaboration will determine the most promising theoretical techniques for their solution. The problems include, for example, electron
collisions with noble gases, cesium and mercury, of interest to the laser, lighting and plasma processing industries. Time-dependent and tim ....Electronic and atomic collision theory. Recently there has been rapid progress in the field of electronic and atomic collisions. Consequently, many new problems have emerged of interest to science and industry. The proposed collaboration will determine the most promising theoretical techniques for their solution. The problems include, for example, electron
collisions with noble gases, cesium and mercury, of interest to the laser, lighting and plasma processing industries. Time-dependent and time independent, relativistic and non-relativistic approaches will be considered, thereby determining the direction of the field for the foreseeable future.Read moreRead less