The first stage of vision: transduction and adaptation in retinal photoreceptors. The project aims to provide a detailed understanding of the molecular steps involved in the first stage of vision - the conversion of light into a neural signal in the rod and cone photoreceptors of the retina. The significance of this is that it will explain the initial events that enable us to see, and will help explain the deficits that occur when the process fails. The outcome will be a comprehensive understand ....The first stage of vision: transduction and adaptation in retinal photoreceptors. The project aims to provide a detailed understanding of the molecular steps involved in the first stage of vision - the conversion of light into a neural signal in the rod and cone photoreceptors of the retina. The significance of this is that it will explain the initial events that enable us to see, and will help explain the deficits that occur when the process fails. The outcome will be a comprehensive understanding of how our photoreceptors respond with extreme sensitivity, yet great rapidity, and over an enormous range of light intensities, thus endowing us with our remarkable sense of vision.Read moreRead less
Assembly of neural circuits during development. This program aims to understand how nerve cells wire up accurately during development. Specifically, the program will determine how neuronal connections are established in the retina to produce a sensory structure essential for vision. The program will also generate innovative tools for watching in live animals, the making and breaking of connections during normal and abnormal development. Discoveries will not only significantly increase our knowle ....Assembly of neural circuits during development. This program aims to understand how nerve cells wire up accurately during development. Specifically, the program will determine how neuronal connections are established in the retina to produce a sensory structure essential for vision. The program will also generate innovative tools for watching in live animals, the making and breaking of connections during normal and abnormal development. Discoveries will not only significantly increase our knowledge base of how the nervous system develops or degenerates, but the results will provide crucial information for future studies based on genetic approaches, drug therapies and bioengineering technology to repair the injured nervous system.Read moreRead less
Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-ter ....Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-terrorism applications; environmental, clinical, and forensic analysis; energy generation and foods. The project will also lead to very significant new intellectual property having extremely high commercial potential worldwide, and thereby generates the promise of considerable direct financial returns to Australia.Read moreRead less
Advanced analysis, behaviour and design of steel and steel-concrete composite engineering structures subjected to elevated temperatures. This Fellowship aims to develop a consistent advanced nonlinear method for the analysis and behaviour of steel and composite building frames that are subjected to elevated temperatures. There is widespread feeling amongst practitioners that, in the absence of reliable techniques for verifying this behaviour, the regulatory need for fire protection of steel is ....Advanced analysis, behaviour and design of steel and steel-concrete composite engineering structures subjected to elevated temperatures. This Fellowship aims to develop a consistent advanced nonlinear method for the analysis and behaviour of steel and composite building frames that are subjected to elevated temperatures. There is widespread feeling amongst practitioners that, in the absence of reliable techniques for verifying this behaviour, the regulatory need for fire protection of steel is excessive, and the high expense involved in providing this protection is leading structural steel being rejected in engineering design. This growing trend is leading to a potential downturn in structural steel production, which has serious economic and social ramifications on Australian communities whose fabric is centred on this activity.Read moreRead less
Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific commun ....Biohumanities: Philosophical, Historical, and Socio-Cultural Studies of Contemporary Bioscience. Improving understanding of the meaning and implications of contemporary bioscience, especially genetics and molecular biology, through bioliterate research in the humanities and social sciences, and conversely through better assimilation of bioscience and its significance by the humanities and social sciences. The research will be conducted in close collaboration with the Australian scientific community and will be disseminated back to the scientific community, to the humanities and to the Australian public. The project will bring to Australia the strengths of the applicant's existing collaborations with leading research centres in this field in the USA, UK and Canada.Read moreRead less
RUSSIA (THE SOVIET UNION) AND AUSTRALIA IN THE 20TH AND 21ST CENTURIES. Revitalize Australian Russian studies by bringing in internationally recognized leadership and cutting-edge projects; making the University of Melbourne's Russian centre not just the southern hemisphere leader in this field but also a significant player worldwide.
Using ancient DNA to understand Australia's past and manage its future. The aim of this program is to establish an ancient DNA research centre for Australia, and use long-term natural records to investigate the genetic responses of animals, plants, and micro-organisms to environmental change. By examining biological processes before, during, and after major changes (eg coral bleaching, salination) the evolution and selective pressures at important genetic loci will be identified, and related to ....Using ancient DNA to understand Australia's past and manage its future. The aim of this program is to establish an ancient DNA research centre for Australia, and use long-term natural records to investigate the genetic responses of animals, plants, and micro-organisms to environmental change. By examining biological processes before, during, and after major changes (eg coral bleaching, salination) the evolution and selective pressures at important genetic loci will be identified, and related to environmental change to enhance effected planning and future management of Australia's ecosystems, biodiversity and tourism. Key records will come from lake-beds, billabongs, coral reefs, rodent nests, megafaunal bones, and ancient human material.Read moreRead less
Deliberative Global Governance. The worldwide movement building deliberative democracy should now address deliberative capacity in whole systems, not just micro innovations such as citizens' juries. This includes global systems such as that addressing climate change; substantial environmental benefits will result. A world populated by more effective democracies - especially in East Asia - is in Australia's national security interest. A century ago, Australia was a world leader in innovations suc ....Deliberative Global Governance. The worldwide movement building deliberative democracy should now address deliberative capacity in whole systems, not just micro innovations such as citizens' juries. This includes global systems such as that addressing climate change; substantial environmental benefits will result. A world populated by more effective democracies - especially in East Asia - is in Australia's national security interest. A century ago, Australia was a world leader in innovations such as the secret ballot and votes for women. Work on deliberative democracy can put Australia back in the forefront of democratic progress, with many associated social, political, and economic benefits.Read moreRead less
Theory for global biodiversity conservation. Australia's biological diversity underpins much of our economic wealth - for example the remarkable diversity of coral reefs fuels a multibillion dollar tourism industry. We will devise methods to make better decisions about where to invest conservation dollars amongst the biodiversity "hotspots" of the world and Australia to deliver environmental sustainability. We will solve the problem of how much of any environmental budget should be spent on mo ....Theory for global biodiversity conservation. Australia's biological diversity underpins much of our economic wealth - for example the remarkable diversity of coral reefs fuels a multibillion dollar tourism industry. We will devise methods to make better decisions about where to invest conservation dollars amongst the biodiversity "hotspots" of the world and Australia to deliver environmental sustainability. We will solve the problem of how much of any environmental budget should be spent on monitoring conservation actions to make better and more cost-effective decisions. We will create new theory and freely available tools for building systems of marine reserves that allow for threats like coral bleaching and hurricanes.Read moreRead less
Ecology and evolution in dynamic systems: a new approach to conserving Australian biodiversity. Australia has different ecosystems and different species than the rest of the world, and we need a different approach to conserve and manage our unique animals. This project will develop a new, specifically Australian-oriented approach to conservation biology.