Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Using lasers to prime the immune system. This project aims to detail the precise effects that lasers have on eye cells, cell populations and the body as a whole. Laser treatments for sight problems are increasing but the effects of these laser applications on the unique immune systems of the eye and brain are unknown. Previous work of the researchers has shown that a novel nanosecond laser when targeted to the eye can alter cells in the lasered eye and in the unlasered eye and the brain. This kn ....Using lasers to prime the immune system. This project aims to detail the precise effects that lasers have on eye cells, cell populations and the body as a whole. Laser treatments for sight problems are increasing but the effects of these laser applications on the unique immune systems of the eye and brain are unknown. Previous work of the researchers has shown that a novel nanosecond laser when targeted to the eye can alter cells in the lasered eye and in the unlasered eye and the brain. This knowledge may be crucial for enhancing our understanding of the immune privileged state of the eye. In addition, it seeks to guide the development of future low energy lasers as important successful treatments.Read moreRead less
Identification And Characterisation Of Novel Genes For Congenital Cataract
Funder
National Health and Medical Research Council
Funding Amount
$432,750.00
Summary
Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Au ....Cataracts are the leading cause of blindness worldwide. The term describes a clouding of the lens which may lead to visual impairment. Congenital cataracts (present at birth) are less common than age-related cataract but the lifelong impact on vision can be severe, with a third of patients remaining legally blind. Late complications such as aphakic glaucoma may be blinding. We have shown that congenital cataracts are often inherited and have performed a population-based study in South-Eastern Australia over the past 5 years to determine the causative genes. A large number of families have been involved in the study and solid progress has been made in identifying mutations in cataract genes and understanding what effect these may have on the patient's prognosis. We have recently identified a new gene in a large Australian family with a syndrome of cataract, mental retardation and teeth problems. This syndrome, known as Nance-Horan syndrome was originally described in Australia 30 years ago and we have worked with the original family to find the exact gene responsible. We already know that this gene causes the same syndrome in other families and in this project we will examine whether it can cause cataract without the other features or mental retardation without cataract. We will perform a series of experiments to learn what this gene does and how it causes the disease. We have also selected 3 other very interesting families with congenital cataracts for further study as we either know already or strongly suspect that they will enable us to identify further new genes for cataract, and in one case mental retardation. Our work in other diseases indicates that understanding the genes in severe young onset cases can give valuable clues to the causes of age-related forms and may in the future enable new ways to prevent and treat the commonest cause of worldwide blindness.Read moreRead less
Using large scale modelling to understand reading development and dyslexia. This project aims to construct a computational model of reading that makes quantitative predictions about reading behaviour and dyslexia. It will test theories of reading development and dyslexia based on what they predict in terms of reading performance, predictions which many theories of dyslexia do not make. The model will be in English, French and Italian, which offer rich and constraining data to test the model. The ....Using large scale modelling to understand reading development and dyslexia. This project aims to construct a computational model of reading that makes quantitative predictions about reading behaviour and dyslexia. It will test theories of reading development and dyslexia based on what they predict in terms of reading performance, predictions which many theories of dyslexia do not make. The model will be in English, French and Italian, which offer rich and constraining data to test the model. The project is expected to explain the link between reading performance and underlying influences and why dyslexia manifests differently in different languages.Read moreRead less
Neourobiology Of Human Epilepsy: Genes, Cellular Mechanisms,network And Whole Brain
Funder
National Health and Medical Research Council
Funding Amount
$17,652,824.00
Summary
The team is comprised of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discovery of the genetic causes of epilepsy. They will continue to identify genes underlying epilepsy and study how genetic variations result in development of seizures. Advanced brain imaging will be used to understand the effects of genetic variation on brain structure and function. This study may lead to new diagnostic methods and treatments for epilepsy.
Visual tracking of multiple objects: A stochastic geometrical approach. Reliable real-time visual multiple-object tracking techniques will open up new applications that enhance the quality of life such as driving safety, traffic monitoring, home security, security and surveillance of public facilities. These new applications have huge commercial potentials, and the technology developed from this project will provide the catalyst for vibrant new industries to grow. In addition, the expertise deve ....Visual tracking of multiple objects: A stochastic geometrical approach. Reliable real-time visual multiple-object tracking techniques will open up new applications that enhance the quality of life such as driving safety, traffic monitoring, home security, security and surveillance of public facilities. These new applications have huge commercial potentials, and the technology developed from this project will provide the catalyst for vibrant new industries to grow. In addition, the expertise developed from the project will provide a competitive edge for Australian industries in aerospace, oceanography, robotics, remote sensing, and biomedical engineering. Read moreRead less
Visual intelligence for safe vehicle operation in industrial environment. Visual intelligence for safe vehicle operation in industrial environment. This project aims to develop safety devices for loosely constrained environments with public access, building on visual-based collision avoidance technology in controlled industrial settings. Increasing productivity in industrial workplaces creates a need for faster industrial vehicles. At fruit and vegetable markets and construction sites, forklift ....Visual intelligence for safe vehicle operation in industrial environment. Visual intelligence for safe vehicle operation in industrial environment. This project aims to develop safety devices for loosely constrained environments with public access, building on visual-based collision avoidance technology in controlled industrial settings. Increasing productivity in industrial workplaces creates a need for faster industrial vehicles. At fruit and vegetable markets and construction sites, forklift drivers, crane operators and crews are under pressure to move faster. The need for higher speed and the enormous human and financial cost of unsafe operations create opportunities for the deployment of intelligent safety devices. The expected outcomes of this project are safer public industrial environments, reductions in work related injuries, injury compensation costs and associated societal burdens.Read moreRead less
Intelligent collision avoidance system for mobile industrial platforms. This project will develop a collision prevention system for mobile industrial platforms that enhances existing artificial vision perception systems to mimic human eye capabilities. The outcomes of this project will result in significant reductions in work related injuries, injury compensation costs and associated societal burdens.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347607
Funder
Australian Research Council
Funding Amount
$306,000.00
Summary
FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged ex ....FishWorks - collaborative infrastructure for zebrafish research. Zebrafish have emerged as a powerful and cost-effective animal model for studying development, biology, and disease. FishWorks represents a large-scale co-operative initiative to develop state-of-the-art zebrafish housing, manipulation, genomics and screening infrastructure in Australia. This will both support and further enhance a core group of high quality researchers to engage in cutting-edge research in areas of acknowledged expertise as well as priority within their respective institutions. In addition, it will facilitate wide-ranging collaborative arrangements to further develop and exploit this research area.Read moreRead less