Controlling Neuroinflammation In Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$639,577.00
Summary
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, with 269,000 Australians currently diagnosed with AD and is expected to soar to about 981,000 by 2050. AD accounts for greater than 60% of all cases of dementia. This grant investigates the role that neuroinflammation plays in the progression and exacerbation of AD and will identify new therapeutic strategies to combat this insidious disease.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Controlling Neuroinflammation In Alzheimer's Disease
Funder
National Health and Medical Research Council
Summary
Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, with 269,000 Australians currently diagnosed with AD and is expected to soar to about 981,000 by 2050. AD accounts for greater than 60% of all cases of dementia. This grant investigates the role that neuroinflammation plays in the progression and exacerbation of AD and will identify new therapeutic strategies to combat this insidious disease.
The Role Of Cellular Microdomains In G-protein Coupled Receptor Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$385,297.00
Summary
Molecules communicate with cells by attaching to proteins called receptors on the outside of cells, and triggering a series of events inside the cell. These events initially include the assembly of multiple proteins at the cell surface. This project will examine the formation of receptors and other proteins into these ‘communication complexes’. This will provide novel targets for more selective drug development.
Contemporary Australian Photography 1980 to the present. Contemporary Australian art photography has burgeoned over the last 25 years but there is no dedicated book length study in the field. This project will fill this gap by putting Australian photography on an international scholarly agenda, which will generate more scholarship on Australian work. It will have enormous national and community benefit for Australian artists, curators and dealers and the general public who are keenly interested ....Contemporary Australian Photography 1980 to the present. Contemporary Australian art photography has burgeoned over the last 25 years but there is no dedicated book length study in the field. This project will fill this gap by putting Australian photography on an international scholarly agenda, which will generate more scholarship on Australian work. It will have enormous national and community benefit for Australian artists, curators and dealers and the general public who are keenly interested in photography. Read moreRead less
Care and Repair: Rethinking Contemporary Curation for Conditions of Crisis. This project aims to address the significant challenge of how to curate contemporary art under conditions of crisis, made acute by the pandemic. It expects to generate new knowledge in the growth areas of contemporary art and curatorial practice, which will be translatable to creative industries seeking solutions to similar challenges. Anticipated outcomes include new models for sustainable, future-oriented creative prac ....Care and Repair: Rethinking Contemporary Curation for Conditions of Crisis. This project aims to address the significant challenge of how to curate contemporary art under conditions of crisis, made acute by the pandemic. It expects to generate new knowledge in the growth areas of contemporary art and curatorial practice, which will be translatable to creative industries seeking solutions to similar challenges. Anticipated outcomes include new models for sustainable, future-oriented creative practice; a stronger international profile for Australian artists and curators; and the establishment of a regional network of artists and curators between Australia and Southeast Asia. This should significantly aid our understanding of how to meet current and future challenges to producers and audiences of contemporary art.Read moreRead less
Experiencing space: sensory encounters from Baroque Rome to neo-baroque Las Vegas. This project focuses on the historical baroque and the neo-baroque and the relationship between them. The aim of the project is to apply a new methodology to the study of baroque and neo-baroque cultures, one grounded in sensory and spatial approaches. The primary case studies will be the cities of Rome and Las Vegas, two cities that are paradigmatic of the baroque and the neo-baroque. Whereas for theorists such a ....Experiencing space: sensory encounters from Baroque Rome to neo-baroque Las Vegas. This project focuses on the historical baroque and the neo-baroque and the relationship between them. The aim of the project is to apply a new methodology to the study of baroque and neo-baroque cultures, one grounded in sensory and spatial approaches. The primary case studies will be the cities of Rome and Las Vegas, two cities that are paradigmatic of the baroque and the neo-baroque. Whereas for theorists such as Jean Baudrillard argue that Las Vegas embodies the postmodern world in excess, this project will instead argue that it is emblematic of the return of a baroque aesthetics that has been nurtured by consumer culture, multi-media conglomeration and digital technology.Read moreRead less
Transforming city spaces: street art, urban cultures, transnational networks. The appearance of urban spaces has a dramatic impact upon the lives of the citizens who live in them. In comparing a range of local and international cities, this project investigates ways in which street art, a new cultural practice, has been transforming experiences of cities, cultural practices and communities.
Avatars and Identities. The avatar, a virtual representation of its user, is the key element of interface technology for everyday computer use in the twenty-first century. While specialist aspects of the avatar have received intensive attention from the technology industries and scholars, the focus of the work to date has been on the technical efficiency of the interface, rather than understanding the full social implications of its use. Through a historical, ethnographic and critical analysis o ....Avatars and Identities. The avatar, a virtual representation of its user, is the key element of interface technology for everyday computer use in the twenty-first century. While specialist aspects of the avatar have received intensive attention from the technology industries and scholars, the focus of the work to date has been on the technical efficiency of the interface, rather than understanding the full social implications of its use. Through a historical, ethnographic and critical analysis of the role of the avatar, in consultation with industry, this project offers a unique opportunity to develop a wider perspective that will contribute to an understanding of the uses and policies for the digital economy.Read moreRead less