Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775489
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Dictionary of Australian Artists Online, DAAO: public release version. The DAAO is already positioned as the sole system for the creation and discovery of research into art history in Australia. The DAAO will provide global exposure of Australian research and artists with tangible benefits both economically for cultural industries (including the art industry and tourism) and socially. It will also increase the breadth and depth of general knowledge of Australian art, contributing to the developm ....Dictionary of Australian Artists Online, DAAO: public release version. The DAAO is already positioned as the sole system for the creation and discovery of research into art history in Australia. The DAAO will provide global exposure of Australian research and artists with tangible benefits both economically for cultural industries (including the art industry and tourism) and socially. It will also increase the breadth and depth of general knowledge of Australian art, contributing to the development of national identity through the diversity and richness of Australia's visual cultures. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100120
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
Design & Art Australia Online Research Tool: enabling next generation e-Research in Australia's visual and design cultures. Design and art Australia online research tool: enabling next generation e-Research in Australia's visual and design cultures: This project builds on the recent and highly successful transformation of Design and Art Australia Online (DAAO). As DAAO increases its information base through its automated harvest facilities (LIEF2012) and draws more active engagement from researc ....Design & Art Australia Online Research Tool: enabling next generation e-Research in Australia's visual and design cultures. Design and art Australia online research tool: enabling next generation e-Research in Australia's visual and design cultures: This project builds on the recent and highly successful transformation of Design and Art Australia Online (DAAO). As DAAO increases its information base through its automated harvest facilities (LIEF2012) and draws more active engagement from researchers, new demands are being placed on the facility. Modifications are required to enhance the capabilities of researchers to expand the scope of research facilities offered. This project will refine schema and mappings of events and works to better match researcher queries and enabling data repurposing for visualisation; automate linking facility between established entity links; and develop researcher collaboration functionalities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100056
Funder
Australian Research Council
Funding Amount
$240,000.00
Summary
Design and Art Australia Online: Sustainable data sharing for Australian researchers and collections. This project will produce a comprehensive and authorative research facility of national and international signi?cance. The enhanced Design and Art Australia Online facility will provide crucial information pertaining to Australia’s art and design heritage that will be open for researchers of all levels, from school students through to higher-education researchers.
Australian art exhibitions 1968-2009: a generation of cultural transformation. The years 1968 to 2009 witnessed a transformation in the way Australians saw the art of their country. This project investigates the impact of increased funding (government and private) and new scholarship on the curating of art exhibitions, and traces the reconfiguration of Australia’s art history that took place in exhibitions during this period.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100201
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Design and art of Australia online, a transformation of the dictionary of Australian artists online. The Design & Art of Australia Online (DAAO) archive provides global exposure for Australian scholarship on art and design, along with tangible economic, social and cultural benefits toward the sustainability of cultural industries.
The next generation of the DAAO will enable cultural policy to be informed by an expanded and growing collection of scholarly research. It contributes to national dig ....Design and art of Australia online, a transformation of the dictionary of Australian artists online. The Design & Art of Australia Online (DAAO) archive provides global exposure for Australian scholarship on art and design, along with tangible economic, social and cultural benefits toward the sustainability of cultural industries.
The next generation of the DAAO will enable cultural policy to be informed by an expanded and growing collection of scholarly research. It contributes to national digital humanities infrastructure by collaboratively working toward efficient discovery of data and interoperative infrastructure. Moreover the DAAO has potential as an enabling technology for Australia's Indigenous visual arts and craft sector in meeting the challenges of unethical conduct, sustainability and further developing international markets.Read moreRead less