Investigation Of The Use Of Innate And CD1-mediated Immune Responses As Biomarkers In Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$144,836.00
Summary
Tuberculosis and other non-tuberculosis mycobacterial infections are major health problems worldwide. There are multiple challenges facing treatment and identification of active versus latent TB infections currently. This project aims to identify and characterise several aspects of the immune system which may be responsible for people developing active infections, including ones which may enable development of diagnostic tests and to monitor treatment. Such a biomarker may also help hasten new d ....Tuberculosis and other non-tuberculosis mycobacterial infections are major health problems worldwide. There are multiple challenges facing treatment and identification of active versus latent TB infections currently. This project aims to identify and characterise several aspects of the immune system which may be responsible for people developing active infections, including ones which may enable development of diagnostic tests and to monitor treatment. Such a biomarker may also help hasten new drug therapies for tuberculosis.Read moreRead less
Defining The Role Of Zinc In Human Macrophage Responses To Salmonella
Funder
National Health and Medical Research Council
Funding Amount
$592,049.00
Summary
It is estimated that one third of the worlds population is affected by mild to moderate zinc deficiency, and that this predisposes to a range of infectious diseases. The immunomodulatory effects of zinc have been appreciated for many years, and indeed zinc supplementation is used to treat severe diarrhoeal diseases. This project aims to understand the anti-infective mechanisms of zinc by focusing on macrophages, a key cell type involved in killing invading microorganisms.