Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment For Women Of Child-bearing Age With Psychotic Symptoms Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$210,480.00
Summary
Schizophrenia is a devastating illness urgently requiring a new treatment approach. We have discovered that estrogen is an effective treatment for women with schizophrenia and are currently trialling a safer Selective Estrogen Receptor Modulator (SERM) known as brain estrogen� in postmenopausal women with schizophrenia. Regulatory permission is now available to trial the SERM in younger women, and we seek to extend our current SERM study into child bearing age women with schizophrenia.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
A Dimensional Approach To Mapping The Risk Mechanisms Of Mental Illness
Funder
National Health and Medical Research Council
Funding Amount
$1,677,975.00
Summary
There is ongoing debate about whether current definitions of mental disorders are accurate. We will use statistical techniques to identify the core dimensions of liability for mental illness, and map how genes and brain organization drive differences between people along each dimension.
Establishing Pathways To Implement And Sustain Evidence Based Fall Prevention In Primary Care: The ISOLVE Project
Funder
National Health and Medical Research Council
Funding Amount
$1,156,546.00
Summary
Researchers in allied health and primary care are partnering with Northern Sydney Medicare Local and the NSW State Falls Program (Clinical Excellence Commission) to establish a multi-disciplinary pathway model for fall prevention. The aim is to establish integrated processes and pathways at the levels of practitioner, practice, and program to identify older people at risk of falls and engage a whole of primary care approach to fall prevention. This project will employ multi-methodologies.
School autonomy reform and Australian public education. This project aims to provide an evidence base for policymakers and practitioners that articulates how Australian public schools at an individual and system level engage with school autonomy reform. The project expects to generate an evidence base and new knowledge in the form of dilemma cases, position papers and a practice framework to support social justice through school autonomy reform. This evidence base will produce national economic ....School autonomy reform and Australian public education. This project aims to provide an evidence base for policymakers and practitioners that articulates how Australian public schools at an individual and system level engage with school autonomy reform. The project expects to generate an evidence base and new knowledge in the form of dilemma cases, position papers and a practice framework to support social justice through school autonomy reform. This evidence base will produce national economic and social benefits for Australian communities by identifying the requisite knowledge and practices that will enable key stakeholders to mobilise school autonomy in ways that produce just outcomes for all students.Read moreRead less
Psychosocial Disability And Return To Work In Younger Stroke Survivors
Funder
National Health and Medical Research Council
Funding Amount
$511,216.00
Summary
Each year about 12,000 Australians of working age survive a stroke. These younger survivors have responsibility for generating an income or providing care for families and state that their main objective is to return to work for financial reasons and to help rebuild confidence and independence. This observational 3 year study will determine thefactors are associated with returning to work, improving the wellbeing of thousands of stroke survivors and their families using multivariate regression.
Sociophysical Interactions: understanding the role of social and tangible technologies in maintaining good habits into old age. How can technology help us 'age well'? The project will study, design and evaluate novel information systems that integrate and support social engagement and physical activity in order to build foundational knowledge about these technologies and maintain the opportunities for social engagement and physical activity in our ageing population.
Scaffolds for bone tissue regeneration and use in orthopaedic applications. Damaged joints do not repair spontaneously, often leading to arthritis. Bone defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. This created a need for scaffolds to provide temporary support for new bone. However they lack the combined physical/biolo ....Scaffolds for bone tissue regeneration and use in orthopaedic applications. Damaged joints do not repair spontaneously, often leading to arthritis. Bone defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. This created a need for scaffolds to provide temporary support for new bone. However they lack the combined physical/biological properties necessary for bone repair. We developed new scaffolds with improved mechanical/biological properties to mimic bone which will lead to new treatments for bone damage.Read moreRead less
Criminalisation of poverty and homelessness in Australia: A national study. The project aims to assess the policing and enforcement of public order crimes and related offences (e.g. obstruct/disobey police, breach of bail, and minor property offences) on individuals experiencing poverty and homelessness. The project endeavours to collect and analyse qualitative data from across Australia on the lived experience of people who are homeless or at risk of homelessness, regarding the impact of crimin ....Criminalisation of poverty and homelessness in Australia: A national study. The project aims to assess the policing and enforcement of public order crimes and related offences (e.g. obstruct/disobey police, breach of bail, and minor property offences) on individuals experiencing poverty and homelessness. The project endeavours to collect and analyse qualitative data from across Australia on the lived experience of people who are homeless or at risk of homelessness, regarding the impact of criminal laws and police powers concerned with presence in, and movement around public places. It will particularly focus on the impact on women, children and Indigenous peoples. The outcomes will seek to reduce the criminalisation of homeless people, by identifying law and policy reform options, and comparing their cost with that of 'business as usual'.Read moreRead less
Computational MultiPhysics Analysis of 3D Structural Damage and Failure. This project aims to develop advanced modelling techniques to assess quantitatively, the impacts of environmental changes caused by climate on structures. New and existing structures need to be climate-resilient to sustain more frequent and hazardous climatic actions. Attention will focus on modelling structural damage caused by extreme loads and MultiPhysics mechanisms caused by climate change. The expected outcome is a ne ....Computational MultiPhysics Analysis of 3D Structural Damage and Failure. This project aims to develop advanced modelling techniques to assess quantitatively, the impacts of environmental changes caused by climate on structures. New and existing structures need to be climate-resilient to sustain more frequent and hazardous climatic actions. Attention will focus on modelling structural damage caused by extreme loads and MultiPhysics mechanisms caused by climate change. The expected outcome is a new computational tool that will benefit Australian society by facilitating more reliable assessments of risks associated with structural damage and failure. This is significant in the design of structures where effective measures to improve functionality can be implemented to add value to an asset's life-cycle management.Read moreRead less