The Management To Optimise Diabetes And MEtabolic Syndrome Risk Reduction Via Nurse-led Intervention (MODERN) Study
Funder
National Health and Medical Research Council
Funding Amount
$1,445,861.00
Summary
There is increasing recognition of society’s responsibility to provide effective and sustainable health care to the entire population and not just selected parts. This practical study will test the impact of a nurse-led, multidisciplinary prevention program to reduce the risk of future cardiovascular events in middle-aged individuals at a high risk of developing cardiovascular disease (CVD) living in regional Australia.
Resolve: A New Treatment - Sensorimotor Retaining With Explaining Pain - For Chronic Low Back Pain.
Funder
National Health and Medical Research Council
Funding Amount
$1,005,534.00
Summary
Most treatments for low back pain that are provided by a GP, physiotherapist or chiropractor are only moderately effective. A new approach is needed. We have developed a new treatment, sensorimotor retraining, based on principles from neuroscience, education, psychology and physiotherapy that we are testing in a randomized controlled trial. If successful this new treatment will provide relief for the millions of Australians who suffer from this debilitating condition.
Immediate Cooling And Emergency Decompression (ICED) For The Treatment Of Spinal Cord Injury: Pilot, Safety And Feasibility Studies
Funder
National Health and Medical Research Council
Funding Amount
$600,008.00
Summary
Victims of Spinal Cord Injury are young, have severe paralysis, complex needs and high lifetime costs. Although urgent surgery greatly improves outcome, it is difficult to achieve because of logistical difficulties. To expand the time window for early surgery, it is proposed to immediately cool patients. This project will conduct the pilot studies necessary before commencing a clinical trial of immediate cooling and emergency decompression (ICED) in patients with cervical spinal cord injuries.
Mechanisms Of Impaired Bronchodilator Response Associated With Fatty Acid Intake In Obese Asthma
Funder
National Health and Medical Research Council
Funding Amount
$694,365.00
Summary
Obese asthmatics typically have a high dietary fat intake, which reduces the efficacy of their asthma medications. We will determine which types of dietary fat affect asthma medications. We will also determine which asthma medications are affected by a high fat load. Finally, we will examine the mechanisms by which fatty acids affect the efficacy of asthma medications. This is will inform new treatment options for managing the many obese asthmatics who are not able to achieve weight loss.
Localised Airway Reactivity As A Determinant Of Asthma Control And AHR
Funder
National Health and Medical Research Council
Funding Amount
$306,562.00
Summary
Asthma morbidity and mortality remain high, with drug cost, days lost from school and work. This may be due to severe asthma in which control cannot be attained. This may be due to localised regions of lung that remain persistently responsive to inhaled irritants. We will examine the location and size of these regions using 3-dimensional ventilation scanning. The potential importance of our findings is in providing a basis for improving treatment in resistant, severe asthma.
Improving Oesophageal Adenocarcinoma Outcomes Through Understanding Genomics And Treatment Toxicity.
Funder
National Health and Medical Research Council
Funding Amount
$1,013,282.00
Summary
Oesophageal adenocarcinoma is an aggressive cancer, as most patients will not survive for more than 5 years. Therefore we need to find better ways to treat patients. In this study we will identify the DNA mutations in oesophageal cancers that were part of clinical trial. The data allow us to determine why some tumours responded well to therapy, and why some patients had serious side effects to the treatment. The results will help inform on selection of therapy for future patients.
While there are numerous therapies for relapsing-remitting multiple sclerosis (MS), therapy for progressive MS remains elusive. This project will evaluate the effect of various therapies on the accumulation of irreversible disability in progressive MS. In addition, it will examine the effect of switching between therapies on MS activity. Finally, the project will indicate whether demographic and clinical information can be used as a predictor of individual patient response to MS therapies.
Physiotherapist Led Stress Inoculation Intervention Integrated With Exercise For Acute Whiplash Injury
Funder
National Health and Medical Research Council
Funding Amount
$518,960.00
Summary
Physical and mental health outcomes following whiplash injury due to a road traffic crash are poor. Early stress system responses are associated with poor recovery. This study will investigate the effectiveness of a physiotherapist led stress inoculation intervention integrated with currently recommended exercise rehabilitation to improve health outcomes after whiplash injury.
Footwear For Self-managing Knee Osteoarthritis Symptoms: The Footstep Trial
Funder
National Health and Medical Research Council
Funding Amount
$590,532.00
Summary
Self-management of symptoms is an important part of treatment for people with knee osteoarthritis. Footwear influences forces across the knee joint and it is unclear which types of shoes are best to minimise arthritis symptoms. This study will compare the effects of flat flexible shoes to stable supportive shoe styles on pain and physical function over 6 months in people with painful knee osteoarthritis.
Can One Health Strategies Be More Effectively Implemented Through Prior Identification Of Public Values?
Funder
National Health and Medical Research Council
Funding Amount
$585,331.00
Summary
Emerging infectious diseases (EIDs) are a significant risk to our region. One Health approaches to EIDs emphasize connections between human,animal and ecological health, enhancing capacity for disease prediction and intervention. This project will examine existing EID legislation,identify social and ethical barriers to effective EID risk governance and create a comprehensive statement of values to ensure the acceptability of One Health approaches to EID control to the Australian community.