Investigating The Incremental Health Benefits Of Improving Water Quantity Versus Improving Water Quality Using Riverbank Filtration Technology (RBF) In Six Rural Communities In India
Funder
National Health and Medical Research Council
Funding Amount
$122,714.00
Summary
Diarrhoea is a leading cause of death and disease globally, largely attributable to unsafe water, inadequate sanitation and poor hygiene. River water is a common water source in India, but water quality is often compromised by contamination. Riverbank Filtration technology (RBF) is an inexpensive means to improve water quality. This project will investigate the health benefits of improving water quantity versus improving water quality using RBF technology in six rural Indian communities.
Optimising Human Vascularisation And Liver Tissue Engineering Models To Develop Functional Bio-artificial Human Liver Tissue
Funder
National Health and Medical Research Council
Funding Amount
$124,761.00
Summary
This project aims to grow human blood vessels and liver cells derived from human stem cells within a supporting scaffold to generate a “liver in a dish”. Transplantation involves connecting blood vessels in this structure to those of the recipient. This should restore function in mice with human-like liver disease, thereby demonstrating potential of this technology to be developed as an alternative to liver transplantation.
A Study Of Various Bone Scaffolds In A Maxillary Sinus Model
Funder
National Health and Medical Research Council
Funding Amount
$61,711.00
Summary
This project investigates using animal derived and artificial bone in regions of the mouth that are deficient and not suitable for replacing missing teeth using dental implants. Traditional techniques of bone replacement require the use of a patient's own bone. These procedures are associated with post-operative morbidity and this bone is present in limited quantity. The use of these bone replacements may overcome these challenges and eliminate the need for using patient's bone.
Improving 3D Scaffolds For Skin Tissue Engineering Using Advanced Biotechnology
Funder
National Health and Medical Research Council
Funding Amount
$68,971.00
Summary
Burns injuries are among the most physically and psychologically debilitating injuries. Patients who suffer from severe, extensive burn injuries can have a shortage of healthy, undamaged donor sites and so skin substitutes are used as alternatives to provide wound healing. However, the newly produced skin does not appear or function normally. The aim of this project is to develop a skin equivalent which will provide rapid regeneration of normal skin and improve a patient’s quality of life.
Tissue Engineering Skeletal Muscle – An Important Link In The Neuro-prosthetic Interface Of Bionic Limbs.
Funder
National Health and Medical Research Council
Funding Amount
$86,733.00
Summary
Limb loss after tumour, trauma, disease or degeneration is a major cause of disability. Use of a patient’s own nerve signals may offer an intuitive method for controlling a robotic limb to regain independence. Delicate nerves are damaged by the electrodes required for recording nerve signals, but muscles tolerate electrodes well. This project aims to create an artificial muscle construct as a bridge between nerve signals and recording electrodes to enable patient control of robotic limbs.
Three Dimensional Ex Vivo Modelling Of Neuromuscular Junction Formation
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
Re-establishing functional connections between neurons and muscle is an important step in the recovery process after neuromuscular injury or surgery. In order to study the connection forming process in isolation a biological model of nerve muscle connection formation is required. This study aims to buid a biological model consisting of neurons and muscles in a three dimensional environment and to assess the quality of the functional connections that develop.
Proof Of Principle For Minimally-Invasive Intravascular Brain-Computer Interface
Funder
National Health and Medical Research Council
Funding Amount
$110,068.00
Summary
Severe injury to limb or spinal cord leads to significant disability. Despite advances in many areas of modern medicine, prosthetic limbs have changed little over decades. A new field of medicine seeks to create a "brain-computer interface" that is capable of controlling a robotic limb, or any electronic device just by thinking. Brain-computer interfaces are currently implanted in an open brain operation. This project aims to demonstrate that a brain-computer interface can be be implanted in a m ....Severe injury to limb or spinal cord leads to significant disability. Despite advances in many areas of modern medicine, prosthetic limbs have changed little over decades. A new field of medicine seeks to create a "brain-computer interface" that is capable of controlling a robotic limb, or any electronic device just by thinking. Brain-computer interfaces are currently implanted in an open brain operation. This project aims to demonstrate that a brain-computer interface can be be implanted in a minimally invasive procedure.Read moreRead less
Application Of Adult Stem Cells To Bioengineered Corneal Epithelium And Endothelium Autografts
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Damage to the cornea causes vision loss. Transplants can restore sight but carry risk of rejection and therefore require anti-rejection therapy, which has side effects. Bioengineered corneal components could replace transplants. Our goals are: 1) Growth of corneal endothelium and epithelium from adult stem cells to reduce the amount of tissue so the patient's own cells could be used. 2) Develop scaffolds that are suitable for implantation or other methods to deliver cells.
Improving Health Services Around The Time Of Childbirth In Places Where Death Rates Are High And Home-births Common
Funder
National Health and Medical Research Council
Funding Amount
$119,335.00
Summary
In settings close to Australia where death rates among mothers and newborns remain high, it is common for childbirth to take place outside of health facilities. This research will develop feasible options for countries aiming to simultaneously improve care in first-line health facilities (which often takes some years), and simultaneously provide some limited services in the home that can reduce deaths immediately.
Understanding Current And Future Opportunities To Promote Healthy Maternal Weight During Pregnancy And The Postpartum Period
Funder
National Health and Medical Research Council
Funding Amount
$75,620.00
Summary
The PhD will document clinical management of maternal weight gain during and post pregnancy, across a range of antenatal care providers and deliver a nine month pilot intervention study for first time mothers, aimed at reducing post pregnancy weight retention and promoting healthy nutrition and physical activity behaviours. Findings from this PhD will inform important future development of healthy weight interventions across the reproductive years.