Improving Treatment Strategies For Chronic Alphaviral Arthritic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$643,624.00
Summary
Chikungunya virus and Ross River virus cause epidemics of acute and chronic arthritic disease in humans, which is often poorly managed with current treatments. This grant seeks to understand the mechanisms that give rise to disease in order to identify improved treatment strategies. Both the persistence of viral replication in joint tissues and unnecessary inflammatory responses appear to be important factors driving chronic disease.
Australian savannah landscapes: past, present and future. Australian savannahs are productive and culturally and biologically significant landscapes but are vulnerable to climate change. The project will determine savannah function (carbon and water balance) for the present and assess how sensitive they have been to past climate variability. The project will then address how they may respond to future climate change.
Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provi ....Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provide real-time decisions for plant operators on the required treatment regime for incoming raw water, and advise them on the optimal reservoir offtake depth. This will potentially minimise treatment costs and health risks for consumers. The ultimate goal is to significantly enhance current water supply management practices.Read moreRead less
Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
Thermal stratification, overturning and mixing in riverine environments. Thermal stratification is common in Australia's rivers due to our hot, drought-prone climate and high human demands relative to available supply, which has led to a significant reduction in flows relative to natural levels. Thermal stratification inhibits mixing, creating stagnant conditions characterised by low oxygen levels and increased concentrations of contaminants, leading to algal blooms, fish kills and systemic dama ....Thermal stratification, overturning and mixing in riverine environments. Thermal stratification is common in Australia's rivers due to our hot, drought-prone climate and high human demands relative to available supply, which has led to a significant reduction in flows relative to natural levels. Thermal stratification inhibits mixing, creating stagnant conditions characterised by low oxygen levels and increased concentrations of contaminants, leading to algal blooms, fish kills and systemic damage to ecosystems. The aim of this project is to develop predictive models for the effects of physical processes such as night-time cooling, wind, turbulence and currents on riverine thermal stratification. This is expected to enable a more accurate determination of the flow rates required to maintain the health of our river systems.Read moreRead less
Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertai ....Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertain benefits. This project’s control system will be guided by quantitative models formulated from multi-pronged, fundamental experiments. The project will quantify microbial chloramine decay and determine mechanisms to increase predictability. The project will develop and demonstrate a real-time control technology which delivered microbiologically safe, cost-efficient drinking water to people in warmer climates, despite warming climate and increasing population.Read moreRead less
Erosion of embankment dams and dam spillways. In excess of $250M is spent annually to maintain, upgrade, improve safety and monitor performance of Australian dams. Improved methods for assessing both spillway and internal erosion, the cause of 50 per cent of embankment dam failures and incidents requiring repairs, will be developed, maximising dam safety and minimising maintenance expenditure.
Towards a climate theory of tropical cyclone formation. In Earth's current climate, about 80 to 90 tropical cyclones form every year around the globe, but the reasons why cyclones form at this rate are unknown. This project will use a combination of theoretical techniques and numerical simulation to elucidate the links between large-scale climate and the rate of tropical cyclone formation. A series of climate model experiments will be performed that also have the potential to improve confidence ....Towards a climate theory of tropical cyclone formation. In Earth's current climate, about 80 to 90 tropical cyclones form every year around the globe, but the reasons why cyclones form at this rate are unknown. This project will use a combination of theoretical techniques and numerical simulation to elucidate the links between large-scale climate and the rate of tropical cyclone formation. A series of climate model experiments will be performed that also have the potential to improve confidence in our predictions of tropical cyclone incidence in a future, changed climate.Read moreRead less
Coupling tropical cyclone and climate physics with ocean waves. It is argued that without accounting for the wave effects directly, the physics of large-scale air-sea interactions is inaccurate and incomplete. The project will introduce explicit coupling of large-scale atmospheric and oceanic phenomena with the physics of surface waves which should lead to improved predictions of tropical cyclones and climate.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100088
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research. A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research: This project is for a high temperature, elemental analysis, gas chromatography, isotope mass spectrometry facility. This would permit the analysis of the isotopes of up to four elements in a range of environmental samples such as tree cell ....A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research. A coupled high temperature elemental analyser - gas chromatograph - mass spectrometer for climate, water and ecological research: This project is for a high temperature, elemental analysis, gas chromatography, isotope mass spectrometry facility. This would permit the analysis of the isotopes of up to four elements in a range of environmental samples such as tree cellulose, ecological samples and dissolved nutrients in surface and ground waters. Results will help improve our understanding of climate - surface water - ground water interactions, ecosystem function, and past climate and environmental change. The new facility will meet the need for organic isotope analyses to better understand the underlying physical processes.Read moreRead less