Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is ....Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is expected to redefine our understanding of the virus-host interactions formed by these important pathogens. By determining the mechanisms of NSV-nucleolus interaction, the project plans to also provide important information for the development of new vaccines/therapeutics for livestock to combat NSVs that target nucleoli.Read moreRead less
Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the struct ....Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the structural basis for their activity. We will do this by chemically synthesising peptides with selected residues mutated to determine their effects on activity.Read moreRead less
Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies ....Water availability and demand: better forecasts, better management. This project aims to improve Australia’s capability in the provision and use of water forecasts for managing water resources. The current water forecasts are not fully utilised by water agencies as they are not sufficiently comprehensive and advanced. This project expects to achieve a step change in the uptake and utility of hydro-climate forecasts through an extensive partnership of leading researchers and operational agencies of hydro-climate forecasting, with federal, state and regional water agencies.Read moreRead less
Effect of faults and barriers on groundwater flow and solute transport. This project will address the role of faults and dykes on groundwater flow and solute transport. Faults and dykes can act as barriers to groundwater flow, yet faults can also be conduits for flow through otherwise impermeable layers. Understanding their role is critical to assessing the impacts of mining, unconventional gas and water resource developments. This project expects to develop new methods to quantify groundwater f ....Effect of faults and barriers on groundwater flow and solute transport. This project will address the role of faults and dykes on groundwater flow and solute transport. Faults and dykes can act as barriers to groundwater flow, yet faults can also be conduits for flow through otherwise impermeable layers. Understanding their role is critical to assessing the impacts of mining, unconventional gas and water resource developments. This project expects to develop new methods to quantify groundwater flow through and along faults and dykes by combining geological, hydraulic and geochemical approaches with detailed 3D numerical models. The expected outcome will be an improved understanding of the role of faults and barriers in subsurface hydrology, and an improved ability to model complex groundwater systems.Read moreRead less
SCANEM : A Scanning and Inspection Method for Urban Pipeline Systems. Water and sewage utilities are crucial factors limiting economic growth and urban amenity. However many of these facilities are subject to corrosion, fracture and collapse and new strategies are now required to provide a sound basis for systematic remediation and replacement. Suitable strategies involving a structural audit and statistical analysis have been proposed by CSIRO and Tyco Water. However new geophysical inspection ....SCANEM : A Scanning and Inspection Method for Urban Pipeline Systems. Water and sewage utilities are crucial factors limiting economic growth and urban amenity. However many of these facilities are subject to corrosion, fracture and collapse and new strategies are now required to provide a sound basis for systematic remediation and replacement. Suitable strategies involving a structural audit and statistical analysis have been proposed by CSIRO and Tyco Water. However new geophysical inspection methods are now required to provide the key physical parameters relating to pipeline condition. Hopefully the EM inspection tool resulting from this project will provide the industrial partners with a unique capacity to satisfy a major global market.Read moreRead less
Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provi ....Data-driven water quality treatment management decision support system. Data-driven water quality treatment management decision support system. This project aims to develop a robust decision support system to predict manganese and the character and concentration of dissolved organic matter in drinking water reservoirs, using intelligent algorithms and data collected through remote autonomous instrumentation. These predicted water quality parameters could be used as model input variables to provide real-time decisions for plant operators on the required treatment regime for incoming raw water, and advise them on the optimal reservoir offtake depth. This will potentially minimise treatment costs and health risks for consumers. The ultimate goal is to significantly enhance current water supply management practices.Read moreRead less
Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean a ....Groundwater flow age distributions: Understanding open pit mine hydrology. This project aims to improve the estimation of the age of groundwater. Understanding groundwater age is critical for sustainable management and environmental tracers are increasingly used for this purpose. However, groundwater samples are inevitably mixtures of water of different ages. Since for most tracers the relationship between tracer concentration and age is not linear, different tracers can produce different mean ages for the sample. This project aims to determine whether it is possible to determine moments of the groundwater age distributions from measurements made with different environmental tracers. The project also aims to examine whether the degree of heterogeneity within the aquifer can be determined from the disparity between ages obtained with different tracers. This project aims to tackle the largest problem with using groundwater chemistry to estimate water age – that mixing processes in the subsurface are never known. Solving this problem will allow much more accurate estimates of groundwater velocity and aquifer recharge rates. The groundwater industry contributes an estimated $6.8 billion per annum to the Australian economy, and this project will contribute to the sustainable management of the groundwater resource.Read moreRead less
Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe t ....Environmental contamination and pig disease: an Australian microbe evolves. The Australian pig industry produces pork commodities from over 4.75 million pigs per year. Infectious diseases in industrial-scale piggeries can have a devastating effect on pork production, particularly on feed conversion efficiency and growth rates, and can pose downstream environmental contamination and food safety risks. This project aims to assess a current infectious disease problem in pigs by studying a microbe that appears to have uniquely evolved in Australia. These results could inform the rational design of monitoring, prevention and treatment strategies to minimise infection outbreaks in Australian pigs and may result in production benefits to the pork industry, reduced environmental microbial contamination and safer food.Read moreRead less
Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertai ....Smart management of disinfectant in chloraminated water-supply systems. Smart management of disinfectant in chloraminated water-supply systems. This project aims to develop an adaptive, real-time control system for managing disinfectant residuals in chloraminated water supply systems. While chloramine delivers microbiologically safe drinking water in warmer climates and in long distribution systems, it is largely unpredictable, costs water utilities millions of dollars annually, and has uncertain benefits. This project’s control system will be guided by quantitative models formulated from multi-pronged, fundamental experiments. The project will quantify microbial chloramine decay and determine mechanisms to increase predictability. The project will develop and demonstrate a real-time control technology which delivered microbiologically safe, cost-efficient drinking water to people in warmer climates, despite warming climate and increasing population.Read moreRead less
Vulnerabilities for environmental water outcomes in a changing climate. This project aims to assess the vulnerability of freshwater ecosystems to extended droughts in a variable and changing climate. Governments around the world are investing in the restoration of regulated river systems with environmental water. However, the risks of climate change for environmental water management are seldom considered. This project will model the change in environmental and consumptive water use during exten ....Vulnerabilities for environmental water outcomes in a changing climate. This project aims to assess the vulnerability of freshwater ecosystems to extended droughts in a variable and changing climate. Governments around the world are investing in the restoration of regulated river systems with environmental water. However, the risks of climate change for environmental water management are seldom considered. This project will model the change in environmental and consumptive water use during extended dry periods, and couple this to models of ecological dynamics and failure thresholds. This will improve the success of Australia’s major environmental water programs in sustaining benefits through future multi-year droughts.Read moreRead less