RISK AND PROTECTION FACTORS FOR NORMAL AND ABNORMAL BRAIN AGEING: A LONGITUDINAL EPIDEMIOLOGICAL MRI STUDY
Funder
National Health and Medical Research Council
Funding Amount
$153,020.00
Summary
Brain is considered the last frontier of medicine, and ageing the major challenge to health care in the 21st century. In this proposal, we bring these two challenges together in a major new longitudinal study of ageing in Canberra that has recently been initiated. This is a longitudinal study of a random community sample covering 3 age groups - 20-24 years, 40-44 years and 60-64 years, with at least 2000 participants in each age group - who are being assessed in 1999-2001, and will be followed u ....Brain is considered the last frontier of medicine, and ageing the major challenge to health care in the 21st century. In this proposal, we bring these two challenges together in a major new longitudinal study of ageing in Canberra that has recently been initiated. This is a longitudinal study of a random community sample covering 3 age groups - 20-24 years, 40-44 years and 60-64 years, with at least 2000 participants in each age group - who are being assessed in 1999-2001, and will be followed up at 4-yearly intervals for 20 years. The focus of the study is on neuropsychiatric disorders (anxiety, depression, substance use and cognitive disorders). In this application, we propose to perform MRI scans and blood tests on a quarter (n-500) of the 60-64 sample to obtain an epidemiological sample for brain morphology. Not only will we be able to study changes in brain morphology over time, and relate it with cognitive function and psychiatric disorder, we will also be able to assess the role of risk and protection factors. We are particularly interested in brain reserve, dietary factors (anti-oxidants, omega 3, wine and folate) and drugs (anti-inflammatory drugs, hormone replacement and vitamin supplements) as protection factors, and hypertension, homocysteine levels, white matter lesions on MRI and low hippocampal volumes as risk factors for cognitive impairment and dementia. We also want to study the brain morphological correlates of Depression in a community sample. The study will enhance our understanding of the ageing brain, both in health and disease, and identify factors that increase or decrease the risk of cognitive impairment and psychiatric disorder in old age.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100229
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
A prototype Scanning Helium Atom Microscope (SHeM) for soft materials. The scanning helium atom microscope (SHeM) has been a tantalising prospect since the birth of quantum physics. The SHeM would have unparalleled resolution and would be completely non-damaging; potentially revolutionising the imaging of soft delicate materials. This project will develop the first SHeM instrument in Australia to study soft matter.
Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team ....Phonon based condensed matter imaging. This project will exploit observations of phonon-based chemical contrast in the SHeM to determine the physics that underpins the imaging mechanism and use them to probe vibrational processes in condensed matter imaging. Imaging is an essential tool for the discovery, application and fabrication of new materials, structures and devices. However, many delicate structures are irrevocably degraded and changed when imaged using conventional microscopy. This team recently invented the scanning helium atom microscope (SHeM), which can image surfaces non-destructively with nanoscale resolution. They will use the SHeM to determine the new fundamental physics that underpins the imaging mechanism. Outcomes include turning SHeM into a tool that materials and biological scientists can use in laboratories worldwide.Read moreRead less
The Role Of Nuclear Architecture In The DNA Damage Response
Funder
National Health and Medical Research Council
Funding Amount
$561,966.00
Summary
The goal of the proposed research is to understand how dynamic changes to the chromatin genome packaging network, interact with the DNA damage response and gene expression machinery, to repair damaged DNA and the impact this has on cancer biology. To do so we are combining cutting edge molecular biology techniques with innovative novel microscopy methods developed by our research team, that far exceed the spatiotemporal resolution currently used to study chromatin biology.
Contribution Of Disturbed Blood Flow And Cerebral Metabolism To White Matter Damage In The Perinatal Brain
Funder
National Health and Medical Research Council
Funding Amount
$369,375.00
Summary
It has been known for some time that the white matter regions of the developing brain are particularly vulnerable to damage. These regions are deep in the brain near the ventricles, and are rich in myelin sheaths wrapped around the nerve fibres running from cell-rich areas in the outer layers of the brain to other regions, and down into the spinal cord. Damage to white matter usually leads to behavioural, learning and motor problems in the newborn infant - in its severest form, seen as cerebral ....It has been known for some time that the white matter regions of the developing brain are particularly vulnerable to damage. These regions are deep in the brain near the ventricles, and are rich in myelin sheaths wrapped around the nerve fibres running from cell-rich areas in the outer layers of the brain to other regions, and down into the spinal cord. Damage to white matter usually leads to behavioural, learning and motor problems in the newborn infant - in its severest form, seen as cerebral palsy. Such outcomes are often associated with the presence of asphyxia and infection during pregnancy, leading to the belief that the damage first arises while the baby is still in utero. In this application we suggest that asphyxia and-or infection during pregnancy cause prolonged disturbances in the regulation of blood flow and integrity of the blood-brain barrier in the developing brain, together with changes in metabolism that result in accumulation of prostaglandins and the toxic hydroxyl radical, leading irreversibly to cell death. If this series of events proves to be true, we have suggested and will test several protocols for protecting the fetal brain, which should be readily translatable to clinical practice.Read moreRead less
Exploring the Fundamentals of Atomically Precise Manufacturing with Scanning Probe Microscopes. Over the past five years, Australian researchers have pioneered the development of a new method for fabricating electrical devices in silicon with atomic precision. By partnering with the world leader in nanotechnology manufacturing, these same researchers now have an opportunity to extend Australia's early lead in this area. The proposed research will lead to new capabilities for Australia within the ....Exploring the Fundamentals of Atomically Precise Manufacturing with Scanning Probe Microscopes. Over the past five years, Australian researchers have pioneered the development of a new method for fabricating electrical devices in silicon with atomic precision. By partnering with the world leader in nanotechnology manufacturing, these same researchers now have an opportunity to extend Australia's early lead in this area. The proposed research will lead to new capabilities for Australia within the growing field of electro-mechanical devices. It will strengthen and broaden Australia's leadership in atomic-scale device fabrication in silicon. It will assist world-leading Australian researchers to evaluate and prioritise the commercial potential of their technologies.Read moreRead less
Three Dimensional Integrated Circuits. Pushing the boundaries of current silicon fabrication technology, this proposal will investigate the possibilities of new 3D architectures to ensure that Australia remains at the forefront of world-wide research into atomic-scale electronics. It creates an important link to the latest technologies in atomistic device modelling in the US, developed at Texas Instruments. More importantly, by anticipating the problems that electronic device manufacturers are c ....Three Dimensional Integrated Circuits. Pushing the boundaries of current silicon fabrication technology, this proposal will investigate the possibilities of new 3D architectures to ensure that Australia remains at the forefront of world-wide research into atomic-scale electronics. It creates an important link to the latest technologies in atomistic device modelling in the US, developed at Texas Instruments. More importantly, by anticipating the problems that electronic device manufacturers are currently facing, and will face over their long-term horizons, the proposed research also seeks to provide Australia with a chance to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less
Atomic Electronics: Precompetitive Research for the Global Semiconductor Industry. The demonstration in Australia that electronic devices in silicon can be fabricated at the atomic-scale has provided a vision for global semiconductor manufacturers. By engaging with leading US companies to tackle the problems industry faces as it attempts to reach this scale, this Fellowship will ensure that Australia remains at the forefront of growing world-wide research into atomic-scale electronics. Equally ....Atomic Electronics: Precompetitive Research for the Global Semiconductor Industry. The demonstration in Australia that electronic devices in silicon can be fabricated at the atomic-scale has provided a vision for global semiconductor manufacturers. By engaging with leading US companies to tackle the problems industry faces as it attempts to reach this scale, this Fellowship will ensure that Australia remains at the forefront of growing world-wide research into atomic-scale electronics. Equally important, by anticipating the problems that electronic device manufacturers are currently facing, and will face over their long-term horizons, the proposed research seeks to provide Australia with a long-term opportunity to lift its involvement in the multi-trillion dollar global semiconductor industry.Read moreRead less