Development Of A Novel Drug For Chronic And Infected Wounds
Funder
National Health and Medical Research Council
Funding Amount
$482,362.00
Summary
Chronic wounds affect more than 9 million people worldwide and demand for wound care is increasing. The annual cost to healthcare systems in the US and Australia in treating such wounds is US$25 billion and AU$3 billion, respectively, and there is urgent need for more effective approaches.
A Novel Mesenchymal Stromal Cell And Biomaterial For Corneal Reconstruction
Funder
National Health and Medical Research Council
Funding Amount
$508,611.00
Summary
Our research group has identified a new cell type (L-MSC) with the potential to treat a variety of eye diseases. We have also developed a novel material from a protein found in silk, that has potential as a vehicle for delivering healthy cells into diseased eyes. The present project will build upon these promising results by evaluating the properties of L-MSC necessary for clinical use and by testing the feasibility of our new cell delivery system.
Role Of Hepatic Stellate Cell And Liver Progenitor Cell Interactions In The Regulation Of Wound Healing And Liver Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$620,716.00
Summary
The liver has a remarkable capacity for regeneration following acute and chronic liver injury, however, the mechanisms which facilitate this wound healing are not understood. This project will examine the interactions between different liver cell populations, including hepatic stellate cells (liver fibroblasts) and liver progenitor cells (stem cells of the liver) and will determine which factors regulate inflammation, liver scarring and restitution of liver mass following chronic liver injury.
Mechanisms Of Hepatic Fibrogenesis In Chronic Liver Disease
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Despite advances made in understanding the mechanisms of liver injury, chronic liver disease continues to be one of the most rapidly growing causes of death in subjects aged <65 years. This is the result of uncontrolled wound healing and regeneration leading ultimately to cirrhosis and liver cancer. This research will identify and characterise pathways that control the wound healing response to liver injury, involving the processes of inflammation, scarring and restitution of normal liver mas ....Despite advances made in understanding the mechanisms of liver injury, chronic liver disease continues to be one of the most rapidly growing causes of death in subjects aged <65 years. This is the result of uncontrolled wound healing and regeneration leading ultimately to cirrhosis and liver cancer. This research will identify and characterise pathways that control the wound healing response to liver injury, involving the processes of inflammation, scarring and restitution of normal liver mass.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101574
Funder
Australian Research Council
Funding Amount
$374,360.00
Summary
Understanding the Long-Term Decline in Internal Migration. The project seeks to provide insights into the changing nature of internal migration. Internal migration rates have declined continuously since the 1970s in most advanced economies. This decline in human mobility may affect the functioning of the economy and individuals’ aspirations, but remains poorly recognised and understood. This project aims to establish the onset and pace of the migration decline for a sample of countries. It also ....Understanding the Long-Term Decline in Internal Migration. The project seeks to provide insights into the changing nature of internal migration. Internal migration rates have declined continuously since the 1970s in most advanced economies. This decline in human mobility may affect the functioning of the economy and individuals’ aspirations, but remains poorly recognised and understood. This project aims to establish the onset and pace of the migration decline for a sample of countries. It also aims to identify the causes of this change by identifying linkages between the drop in migration rates and the broader socio-demographic transitions of the past 30 years in Australia, Canada and the United Kingdom. Understanding this issue may support the development of appropriate economic and social policy responses.Read moreRead less
Modulating Skin Regenerative Responses To Improve Wound Repair And Fight Carcinogenesis
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
Skin disorders, such as hard to heal wounds or the most common skin cancers, are a major burden on the national health system. Despite their different nature they employ similar mechanisms of response to injury. In this project we intend to develop a comprehensive understanding of the genetic and molecular mechanisms at play to allow clinical interventions to prevent or to cure these disorders.
Understanding the structure of internal migration in Australia. This project will analyse patterns and processes of interregional migration in Australia from 1976-2001 and forecast their future trajectory. It will use a unique database to focus on the spatial structure and demographic dimensions of migration, evaluate a new source of migration statistics, develop and test a suite of migration indicators, examine how cohort size and age composition influence migration, and develop new methods of ....Understanding the structure of internal migration in Australia. This project will analyse patterns and processes of interregional migration in Australia from 1976-2001 and forecast their future trajectory. It will use a unique database to focus on the spatial structure and demographic dimensions of migration, evaluate a new source of migration statistics, develop and test a suite of migration indicators, examine how cohort size and age composition influence migration, and develop new methods of setting internal migration scenarios in sub-national population forecasts. The results will aid understanding of migration dynamics in Australia and internationally, and significantly enhance the knowledge base for spatial planning and policy formulation.Read moreRead less
A Place to Call Home: expediting repatriation and ending the practice of warehousing refugees and internally displaced persons (IDPs). Half of the world's 12 million refugees and 25 million IDPs have been living in camps for five to ten years (and longer). The proposed model for refugee and IDP repatriation and reintegration will: significantly increase their human security; alleviate the economic burden on host countries; contribute to the development goals of the countries of origin; facilitat ....A Place to Call Home: expediting repatriation and ending the practice of warehousing refugees and internally displaced persons (IDPs). Half of the world's 12 million refugees and 25 million IDPs have been living in camps for five to ten years (and longer). The proposed model for refugee and IDP repatriation and reintegration will: significantly increase their human security; alleviate the economic burden on host countries; contribute to the development goals of the countries of origin; facilitate the targeting of humanitarian assistance for resolving protracted refugee and IDP situations; and reduce the threats to regional stability. The research will also enhance both Australia's reputation in this humanitarian sector and its institutional capacity to successfully repatriate and reintegrate refugees and IDPs.Read moreRead less
Determinants, Motives and Channels of Pacific Island Workers' Remittances from Australia. This research will inform current policy debate on the benefits to migrant-sending communities of expanding migration opportunities for migrants from the Pacific islands through targeted worker schemes. Australian industry and agricultural employers are experiencing acute labour shortages while Pacific island governments are urging Australia and New Zealand to open their labour markets to low-skilled worker ....Determinants, Motives and Channels of Pacific Island Workers' Remittances from Australia. This research will inform current policy debate on the benefits to migrant-sending communities of expanding migration opportunities for migrants from the Pacific islands through targeted worker schemes. Australian industry and agricultural employers are experiencing acute labour shortages while Pacific island governments are urging Australia and New Zealand to open their labour markets to low-skilled workers in the face of growing unemployment and political instability. The findings will also provide Australian foreign aid organisations with a better understanding of the way in which migrants' remittances are determined and migrant's interaction with money transfer agencies.Read moreRead less
Humanitarian migrants' settlement in Australia: A longitudinal study. Current evidence suggests that humanitarian migrants settle less successfully than other immigrants both economically and socially. This project aims to examine the causal mechanisms and pathways to economic, sociocultural and political settlement outcomes of humanitarian migrants to Australia. This project expects to generate new knowledge in the area of humanitarian migrants’ settlement by using nationally representative dat ....Humanitarian migrants' settlement in Australia: A longitudinal study. Current evidence suggests that humanitarian migrants settle less successfully than other immigrants both economically and socially. This project aims to examine the causal mechanisms and pathways to economic, sociocultural and political settlement outcomes of humanitarian migrants to Australia. This project expects to generate new knowledge in the area of humanitarian migrants’ settlement by using nationally representative data and cutting-edge longitudinal techniques.Expected outcomes include enhanced research capacity in causal methods, interdisciplinary and institutional collaborations, and evidence-based social policy for humanitarian migrants, significantly benefitting humanitarian migrants directly and society more broadly. Read moreRead less