Participation following traumatic brain injury in rural, regional and remote areas. The results of this project will lead to improved rehabilitation programs and better outcomes for people with brain injury, especially in regional, rural and remote areas, by targeting the ultimate goal more directly: participation - getting people back into their home, work and community roles. Participation is associated with improved social networks, wellbeing, independence and quality of life, so health care ....Participation following traumatic brain injury in rural, regional and remote areas. The results of this project will lead to improved rehabilitation programs and better outcomes for people with brain injury, especially in regional, rural and remote areas, by targeting the ultimate goal more directly: participation - getting people back into their home, work and community roles. Participation is associated with improved social networks, wellbeing, independence and quality of life, so health care burdens and costs are reduced, and people can lead more productive lives. The project's emphasis on country areas will benefit rural health care, and also help specialist metropolitan brain injury services to understand the specific rehabilitation issues facing people from the bush.Read moreRead less
Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to tran ....Gene therapy to enhance auditory prosthesis performance for cochlear implants. The cochlear implant is the most effective neural prosthesis, restoring hearing to the deaf. The research aims to develop a new type of implant compatible with delivery of therapeutic genes to the cells lining the cochlea. Gene therapy DNA constructs will be developed that will enhance neural survival and growth, improving cochlear implant performance. The research will provide advances in understanding how to transfer genes into cochlear tissue, as well as development of gene cassettes for effective neural repair. The work will advance the field of bionics, an area where Australia is establishing international preeminence.Read moreRead less
Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa. The purpose of this project is to harness the expertise available within an Australian biotechnology company, Gradipore, to develop novel methods for the preparation of mammalian spermatozoa and the segregation of these cells into X-and Y- bearing populations. This technology will find application in: (1)clinical andrology, where rapid, safe protocols for the preparation and segrega ....Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa. The purpose of this project is to harness the expertise available within an Australian biotechnology company, Gradipore, to develop novel methods for the preparation of mammalian spermatozoa and the segregation of these cells into X-and Y- bearing populations. This technology will find application in: (1)clinical andrology, where rapid, safe protocols for the preparation and segregation of human spermatozoa are being actively sought in the context of assisted conception and the management of sex-linked genetic diseases and (2) agriculture, particularly the cattle industry, where a capacity to predetermine the sex of the offspring would be extremely valuable.Read moreRead less
Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This inform ....Development of the PD GeneChip: a research and diagnostic tool for Parkinson's disease. The PD GeneChip will provide both social and economic benefits to Australia. It will be a key research platform for Australian scientists, and will facilitate collaboration both within Australia and overseas. It will assist with health care management of PD (Parkinson's disease) patients by providing a cost-effective diagnostic tool and the possibility of predicting the clinical course of disease. This information will provide the basis for tailoring treatment to a patients needs. It is anticipated that marketing of the PD GeneChip within Australia and overseas may produce revenue of at least $40 million annually.Read moreRead less
Mammalian chitinases and gene therapy: new weapons to combat fungal and insect attack in mammals. Plants combat fungal and insect attack by producing chitin degrading enzymes. Related, chitinolytic enzymes have been identified in mammals, but their functions are unclear. We found that chitinases from human macrophages inhibited fungal growth. We hypothesise that, like plants, mammalian chitinases are produced to fight chitin containing pathogens. We will transform cells with a chitotriosidase ge ....Mammalian chitinases and gene therapy: new weapons to combat fungal and insect attack in mammals. Plants combat fungal and insect attack by producing chitin degrading enzymes. Related, chitinolytic enzymes have been identified in mammals, but their functions are unclear. We found that chitinases from human macrophages inhibited fungal growth. We hypothesise that, like plants, mammalian chitinases are produced to fight chitin containing pathogens. We will transform cells with a chitotriosidase gene and encapsulate them, creating bioreactors secreting chitinases. Therapeutic effects will be tested by grafting bioreactors to mice inoculated with Aspergillus. The research is a new approach to fighting chitin containing pathogens, with potential applications from parasite infestations in livestock to fungal infections in humans.Read moreRead less
A phenomenological approach to improve radioembolisation treatment of cancer. In recent years, radioembolisation for liver cancer has become an effective therapeutic option. However, it is likely that patients are being “under-treated” as doses remain based on results from external radiation therapy. This project will develop a phenomenological approach to radionuclide therapy to improve outcomes for cancer patients.
Influence of an innovative shoe design on lower limb joint loading during walking. This project will provide new knowledge about the effects of shoe design features on lower limb loading and the influence of obesity and knee condition on the shoe-mediated biomechanical effects. This will be of relevance to researchers and clinicians. It is also likely to contribute to a marketable commercial product, a shoe designed to reduce knee loading. This shoe has the potential to contribute to reducing th ....Influence of an innovative shoe design on lower limb joint loading during walking. This project will provide new knowledge about the effects of shoe design features on lower limb loading and the influence of obesity and knee condition on the shoe-mediated biomechanical effects. This will be of relevance to researchers and clinicians. It is also likely to contribute to a marketable commercial product, a shoe designed to reduce knee loading. This shoe has the potential to contribute to reducing the societal and personal burden of knee osteoarthritis, one of the most prevalent and costly chronic conditions in the developed world. Read moreRead less
Captions for the Deaf and Hearing Impaired: Availability versus Accessibility. The availability of educational, informational and recreational services for deaf and hearing-impaired people has been dramatically facilitated by (i) increased television captioning due to the 2001 introduction of the Television Broadcasting Services Act; and (ii) trial introduction of real-time captioning in educational settings. These innovations must be matched by equally innovative ways of increasing the accessib ....Captions for the Deaf and Hearing Impaired: Availability versus Accessibility. The availability of educational, informational and recreational services for deaf and hearing-impaired people has been dramatically facilitated by (i) increased television captioning due to the 2001 introduction of the Television Broadcasting Services Act; and (ii) trial introduction of real-time captioning in educational settings. These innovations must be matched by equally innovative ways of increasing the accessibility of captions, which is currently limited by English literacy, caption speed, and caption reduction techniques. Here, systematic manipulation of these factors in experiments on television captioning with adults and educational captioning with children will determine how resources might best be directed to improving caption accessibility.Read moreRead less
Collaborative approaches to the prevention of work related injuries in railway workers. RailCorp NSW is a large employer within the NSW transport industry sector and as such has a high potential exposure to occupational injury. RailCorp has committed to the safety of its employees through its efforts towards a systematic identification of injury risk factors to create a safer workplace as well as creating a 'risk aware safety culture'. Interventions which are effective in reducing the incidenc ....Collaborative approaches to the prevention of work related injuries in railway workers. RailCorp NSW is a large employer within the NSW transport industry sector and as such has a high potential exposure to occupational injury. RailCorp has committed to the safety of its employees through its efforts towards a systematic identification of injury risk factors to create a safer workplace as well as creating a 'risk aware safety culture'. Interventions which are effective in reducing the incidence and severity of work related injuries have not only immediate benefits both in terms of human (workforce retention, job satisfaction, job performance, etc) and financial factors for RailCorp management and its employees but has wider applications to other comparable complex high risk industries.
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A hands-free assistive control system for the severely disabled capable of operating under stressful and fatiguing conditions. The impact of severe disability like tetraplegia in daily living is substantial. Strategies are needed to improve their quality of life. One approach is to enhance their independence by providing 'hands free' control over their environment. However, few scientific studies have examined the efficacy of such technology. The aim of this research is to study the brain activi ....A hands-free assistive control system for the severely disabled capable of operating under stressful and fatiguing conditions. The impact of severe disability like tetraplegia in daily living is substantial. Strategies are needed to improve their quality of life. One approach is to enhance their independence by providing 'hands free' control over their environment. However, few scientific studies have examined the efficacy of such technology. The aim of this research is to study the brain activity of users of our "hands free" technology when they are operating under stressful and fatiguing conditions. The study should provide valuable data that will allow us to improve the efficacy of our existing brain signal based system (Mind Switch Assistive System). Read moreRead less