Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less
A Randomised Controlled Trial (RCT) Of Azithromycin Versus Doxycycline For The Treatment Of Rectal Chlamydia Infection In Men Who Have Sex With Men.
Funder
National Health and Medical Research Council
Funding Amount
$797,906.00
Summary
Rectal chlamydia is very common among gay men; it can exist for long periods without symptoms leading to ongoing transmission. Azithromycin (1 gram single dose) or 7 days doxycycline (100mg twice daily) are the two recommended treatments globally. But, there is concern about rectal chlamydia treatment with reports of up to 22% failure following azithromycin. We will conduct a randomised trial to compare these treatments for rectal chlamydia and determine which drug works better.
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revol ....ARC Centre of Excellence in Convergent Bio-Nano Science and Technology. The CoE in Convergent Bio-Nano Science &Technology comprises a multi-disciplinary team focused on research aiming to understand and control the interface of materials with biological systems. The Centre will exploit knowledge of the bio-nano interface to design materials that transport and deliver vaccines, drugs and gene therapy agents, and to design new diagnostic agents and devices. Nanomedicines are on the cusp of revolutionizing diagnosis and therapy in many diseases. The CoE will be the focus of bio-nano research activity in Australia, uniting universities, research agencies, institutes and companies. The expected outcomes are better diagnostic and therapeutic tools designed via an enhanced understanding of the bio-nano-interface.Read moreRead less
An In Depth Analysis Of Clinical And Virological Outcomes Of 2 Strategies For The Antiretroviral Salvage Of First-line Regimen Virological Failure For HIV-1 Infection Tested In An Australian-led Randomised, International, Multi-centre Clinical Trial
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
The recently completed Australian-led SECOND-LINE trial is the first high quality study to provide reliable evidence for policy recommendations for the composition of anti-HIV drug cocktails after standard initial treatment has failed. This award will support the researcher in further refining our understanding of how to manage second-line therapy including proposals to test the use of low-cost technologies for application in resource-limited settings where the majority of people with HIV live.
Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student a ....Improving student outcomes: coaching teachers in the power of feedback. This project aims to investigate how student outcomes can be augmented through coaching teachers in effective feedback practice. The project addresses a critical problem of stagnating levels of student achievement in Australian schools with the innovative research design combining evidence-based, pedagogies of feedback, formative assessment and instructional coaching to improve teacher practice and ultimately raise student achievement levels. The project aims to guide policy implementation in pedagogy to raise the quality of teaching standards and to improve learning outcomes for Australian students. Ultimately, outcomes from the research will help close the gap for low achieving students, and challenge and extend those who may already be meeting required benchmarks. Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Increasing the rural medical workforce: investigating personal traits to enhance our understanding and improve training of rural registrars. This project will research new methodologies for increasing the number of rural doctors in Australia. A better understanding of those individuals best suited for rural practice will provide value for money to the Government by making the most efficient use of initiatives to increase recruitment and retention of the rural workforce.
Are the kids alright? Understanding the wellbeing of Australian children in their middle years. This project will produce the first comprehensive national stock-take of wellbeing among Australian children in their middle years, with a special focus on children who experience disadvantage. Findings will reflect children's views and experiences, have direct policy relevance and lay the groundwork for comparing and monitoring of child wellbeing.
Building sound ecological restoration strategies for endangered amphibians. This project integrates the principles of ecology and restoration ecology to secure the persistence of a population of an endangered frog in the context of a large urban renewal and ecological rehabilitation precinct at the Sydney Olympic Park. Habitat rehabilitation at the site provides an unrivalled opportunity for ecology to provide robust scientific direction and support for conservation management practices and deve ....Building sound ecological restoration strategies for endangered amphibians. This project integrates the principles of ecology and restoration ecology to secure the persistence of a population of an endangered frog in the context of a large urban renewal and ecological rehabilitation precinct at the Sydney Olympic Park. Habitat rehabilitation at the site provides an unrivalled opportunity for ecology to provide robust scientific direction and support for conservation management practices and develops the site as a model site illustrating adaptive management practices. The project investigates the role of two threatening processes in amphibian decline in a habitat management context and the outcomes have wide implications for the global amphibian decline. Read moreRead less
Identifying cost-effective reforestation approaches for biodiversity conservation and carbon sequestration in the Australian wet tropics. There is great potential for rainforest reforestation to help in the protection of Australia's tropical flora and fauna. Little is known, however, about how to reforest pasture to rainforest for the purpose of maximising the recovery of native biodiversity. We propose a unique experimental study of rainforest reforestation practices with biodiversity conservat ....Identifying cost-effective reforestation approaches for biodiversity conservation and carbon sequestration in the Australian wet tropics. There is great potential for rainforest reforestation to help in the protection of Australia's tropical flora and fauna. Little is known, however, about how to reforest pasture to rainforest for the purpose of maximising the recovery of native biodiversity. We propose a unique experimental study of rainforest reforestation practices with biodiversity conservation as a primary goal. Reforestation is currently an unlikely option for most landholders in Australia's tropics given the lack of data on the economic benefits obtainable from such efforts. Our study examines the profits obtainable through the carbon market for each reforestation approach with the goal of increasing the feasibility of rainforest reforestation in North Queensland.Read moreRead less