Targeting Iron Piracy From Host Proteins By Neisseria And Haemophilus Spp. For The Development Of Novel Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Social cohesion and resilience through intercultural music engagement. This project aims to identify, evaluate and develop theoretical and practical ways in which intercultural music engagement can facilitate social cohesion and enhance community resilience and intercultural empathy. There is growing evidence that music is a powerful stimulus for wellbeing and interpersonal connection and it is increasingly applied to promote intercultural understanding. This project will use detailed observatio ....Social cohesion and resilience through intercultural music engagement. This project aims to identify, evaluate and develop theoretical and practical ways in which intercultural music engagement can facilitate social cohesion and enhance community resilience and intercultural empathy. There is growing evidence that music is a powerful stimulus for wellbeing and interpersonal connection and it is increasingly applied to promote intercultural understanding. This project will use detailed observational, participatory and experimental strategies to elucidate the psychosocial processes underpinning intercultural music engagement, isolating variables that promote social cohesion. The project will develop best practice guidelines for organisations seeking to use cultural exposure and interaction to promote positive multicultural experiences.Read moreRead less
Programmed cell death signalling in innate immunity. This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic un ....Programmed cell death signalling in innate immunity. This proposal aims to address the under-explored potential for programmed cell death to promote innate immune cell signalling, which is a critical and fundamental biological process. It aims to generate new knowledge in the areas of cell death and innate signalling using innovative interdisciplinary approaches and discover new molecules that impact innate inflammatory responses. The expected outcomes of this project are to enhance our basic understanding of cell death, and build interdisciplinary collaborations. This work should provide significant benefit to the economy and health of Australians, as it is expected to identify molecules that will be of interest to the pharmaceutical and biotechnology industries.Read moreRead less
Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a ....Improving the efficiency of CRISPR gene editing in cells. Human red blood cells are well-characterised and the globin gene locus is a model system for the study of gene regulation. Gene editing technologies and delivery tools are evolving rapidly and the globin gene locus is the perfect model for gene editing optimisation. This collaboration between UNSW Sydney and CSL aims to bring together our combined expertise and new technologies to develop an optimal platform for genetic modification in a red blood cell line. Simultaneously, this project aims to generate fundamental insights into mechanisms of human gene regulation. The technological and biological outcomes of this project will be of benefit for future gene editing applications.Read moreRead less
Prediction of phenotype for multiple traits from multi-omic data. This project aims to develop better methods for predicting traits in an individual based on their genome sequence. This method will be tested in agricultural animals and plants and in humans. The prediction formula is derived from a training dataset that has information on the traits and genome sequence of a sample of individuals. The prediction formula can then be applied to predict the trait in individuals where the trait is un ....Prediction of phenotype for multiple traits from multi-omic data. This project aims to develop better methods for predicting traits in an individual based on their genome sequence. This method will be tested in agricultural animals and plants and in humans. The prediction formula is derived from a training dataset that has information on the traits and genome sequence of a sample of individuals. The prediction formula can then be applied to predict the trait in individuals where the trait is unknown. This is useful for selecting the best parents for breeding in agriculture and for predicting the future phenotype of animals, crops and people. The proposed method uses data on very many traits to identify sequence variants that have a function and to predict the traits affected by each variant.Read moreRead less
Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. T ....Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. These pedagogies will ‘infuse’ multiliteracies in senior school science to improve access to science-based pathways for these students, and enable them to understand progressively more complex scientific concepts and demonstrate this in examinations. This project is expected to improve student retention, arrest declining enrolments in senior school science, and increase young people working in science.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100515
Funder
Australian Research Council
Funding Amount
$423,652.00
Summary
Teaching digital writing in secondary English. In a digital world the nature of writing is changing. This project investigates how secondary English teachers are conceptualising and teaching digital writing, and how they perceive this work can be enhanced to create more engaged and empowered students, workers and citizens. The study contextualises contemporary digital writing pedagogy in the history of English teaching and provides insights into how teachers respond to demands for 21st century l ....Teaching digital writing in secondary English. In a digital world the nature of writing is changing. This project investigates how secondary English teachers are conceptualising and teaching digital writing, and how they perceive this work can be enhanced to create more engaged and empowered students, workers and citizens. The study contextualises contemporary digital writing pedagogy in the history of English teaching and provides insights into how teachers respond to demands for 21st century literacies. The project, of both national and international significance, will contribute to policy, professional learning and teacher education, and shape capacity for the education of adept writers for digital futures.Read moreRead less
Building Durable Responses to Gender Inequality in Indonesia. This project aims to produce the first longitudinal and comparative study of which aspects of gender equity and women’s empowerment interventions prove most durable for addressing gender inequality in Indonesia, despite external shocks such as the pandemic. The project produces an analysis of how women might remain resilient over time and the pathways by which durability is achieved in improving women's wellbeing and gender relations ....Building Durable Responses to Gender Inequality in Indonesia. This project aims to produce the first longitudinal and comparative study of which aspects of gender equity and women’s empowerment interventions prove most durable for addressing gender inequality in Indonesia, despite external shocks such as the pandemic. The project produces an analysis of how women might remain resilient over time and the pathways by which durability is achieved in improving women's wellbeing and gender relations in communities, and inclusive policies and institutions. Analysis will generate, translate and share new knowledge benefiting civil society partners, academics, policy makers and development practitioners in Indonesia, Australia and beyond, so gender equality interventions can better withstand future shocks.Read moreRead less
Enriching mathematics and science learning: an interdisciplinary approach. This international, longitudinal project aims to investigate the effectiveness of an innovative interdisciplinary learning approach in mathematics and science. Through collaborating primary schools in Australia and the United States of America (USA), it will investigate how students’ invention and transformation of representational systems can connect to support deeper reasoning and learning. The project will form the ba ....Enriching mathematics and science learning: an interdisciplinary approach. This international, longitudinal project aims to investigate the effectiveness of an innovative interdisciplinary learning approach in mathematics and science. Through collaborating primary schools in Australia and the United States of America (USA), it will investigate how students’ invention and transformation of representational systems can connect to support deeper reasoning and learning. The project will form the bases for new curricular designs that leverage students’ representational practices across science, technology, engineering and mathematics (STEM) disciplines to promote more robust and generative knowledge.Read moreRead less