Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.
Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planner ....Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planners at both local and national levels, to design strategies to effectively recruit and retain nurses as demands for health care and market competition for staff both increase.Read moreRead less
Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for ....Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for heterogeneity in treatment responses, and the findings will be combined with a study of regulatory and administrative processes to support the ultimate goal of a legitimate, fair, cost-effective and responsive tax system.Read moreRead less
Back to the Future: Interglacial Warming and the West Antarctic Ice Sheet . The Antarctic is highly-sensitive to abrupt changes caused by the passing of tipping points within the climate system. Crucially, the instrumental record is too short to resolve major uncertainties surrounding future warming. The Last Interglacial (125,000 yrs ago) was 2°C warmer than today and experienced 6-11 m higher global sea levels. The role of Antarctica is vital for constraining sea-level projections. This Austra ....Back to the Future: Interglacial Warming and the West Antarctic Ice Sheet . The Antarctic is highly-sensitive to abrupt changes caused by the passing of tipping points within the climate system. Crucially, the instrumental record is too short to resolve major uncertainties surrounding future warming. The Last Interglacial (125,000 yrs ago) was 2°C warmer than today and experienced 6-11 m higher global sea levels. The role of Antarctica is vital for constraining sea-level projections. This Australian-led international project aims to determine the mechanisms and impacts of past interglacial Antarctic warming up to 2°C (relative to pre-industrial). Innovative techniques integrating horizontal ice cores and high resolution marine records will help identify polar tipping points and better plan for impacts in Australia.Read moreRead less
Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data stream ....Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data streams. This project will use high-resolution global and regional ocean/sea-ice models to examine mechanisms for rapid warming of Antarctic continental shelf waters via both large-scale drivers and fine-scale processes, including mesoscale eddies, tide-topography interactions, and bottom boundary flows. This work will better constrain future rates of ice melt around Antarctica by providing vital knowledge of the ocean processes, dynamics, and feedbacks relating to warm water intrusion onto the Antarctic continental shelf.Read moreRead less
Examining the vulnerability of ocean carbon biogeochemistry in a high CO2 world. Rising CO2 levels in the atmosphere from human activity is changing the biogeochemistry of the ocean, with large potential consequences on future atmospheric CO2. This work will explore these changes and will result in a more complete understanding of how the ocean will either accelerate or delay the increase in atmospheric CO2.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100028
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes ....Australian Membership of the International Ocean Discovery Program. This proposal is for an 18-month membership of the International Ocean Discovery Program (IODP), the world’s largest collaborative research program in Earth and Ocean sciences. The Program studies the history and current activity of the Earth by conducting seagoing coring expeditions and monitoring of instrumented boreholes, using globally unique infrastructure that Australians would otherwise have no access to. Program outcomes include understanding past global environmental change on multiple time scales, the deep biosphere, plate tectonics, formation and distribution of resources, and generation of hazards. These outcomes are paramount to Australia’s national science and research priorities, and societal and economic prosperity.Read moreRead less
Are proposed land-based sinks for greenhouse gases resilient to climate change and natural variability? One strategy to reduce the scale of future climate change is to enhance the storage of carbon in vegetation and soils. Evidence suggests carbon stored in vegetation and soils is itself vulnerable to climate change, placing this stored carbon at risk; this project will assess this risk to advise on the reliability of using terrestrial systems as carbon sinks.
Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. Th ....Incorporating new knowledge of phytoplankton diversity and nutrient utilisation into an ocean-climate model to improve forecasts of ocean function. Phytoplankton drives ocean biogeochemical cycles and regulate Earth’s climate yet are poorly represented in ocean-climate models. This project will use advanced cell sorting and analysis techniques and innovative selection experiments to gain a deeper understanding of phytoplankton diversity and nutrient utilisation under projected climate change. This new knowledge will be used to improve the biological structure of an existing coupled ocean-climate model and reduce key uncertainties in forecasts of ocean function. This research will provide managers and industry with more accurate insight into the effects of ongoing climate change on the delivery of ecosystem services in eastern Australian waters.Read moreRead less
Remote forcing of Pacific Ocean variability and impacts on global climate. Variability in the Pacific Ocean has a profound impact on global climate. Recent unprecedented decadal variability in the Pacific has been linked to global temperature trends and extremes, yet little is known about what drives this variability or its impact on regional climate. This project will combine observations, advanced coupled climate models and ocean-atmosphere dynamical theory to quantify remote drivers of Pacifi ....Remote forcing of Pacific Ocean variability and impacts on global climate. Variability in the Pacific Ocean has a profound impact on global climate. Recent unprecedented decadal variability in the Pacific has been linked to global temperature trends and extremes, yet little is known about what drives this variability or its impact on regional climate. This project will combine observations, advanced coupled climate models and ocean-atmosphere dynamical theory to quantify remote drivers of Pacific Ocean variability on interannual-decadal time-scales. This project aims to enhance our understanding of the modes of variability operating in this region and their impact on global and Australian climate. This will have significant benefits for the many sectors of society reliant on interseasonal-decadal climate prediction.Read moreRead less