Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.
Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planner ....Patient and nurse outcomes and the cost of nurses' turnover in Australian hospitals. An adequate supply of nurses is fundamental to all of the National Health Priority disease areas where quality care cannot be delivered without an adequate number of motivated nurses. Designing cost-effective methods of retaining nurses requires understanding reasons why they leave the workforce and the impact this has on patient care and system costs. The findings will assist policy makers and workforce planners at both local and national levels, to design strategies to effectively recruit and retain nurses as demands for health care and market competition for staff both increase.Read moreRead less
Space gravity: squeezing the last drop of hydrological information out of current and future missions. Australia needs space gravity measurements in order to estimate regional-scale total water storage changes on our continent. This project will deliver the analysis capability required to exploit all the measurements of the current Gravity Recovery and Climate Experiment (GRACE) mission and to place Australia in a state of readiness for the 2017 GRACE Follow On mission.
Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for ....Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for heterogeneity in treatment responses, and the findings will be combined with a study of regulatory and administrative processes to support the ultimate goal of a legitimate, fair, cost-effective and responsive tax system.Read moreRead less
Back to the Future: Interglacial Warming and the West Antarctic Ice Sheet . The Antarctic is highly-sensitive to abrupt changes caused by the passing of tipping points within the climate system. Crucially, the instrumental record is too short to resolve major uncertainties surrounding future warming. The Last Interglacial (125,000 yrs ago) was 2°C warmer than today and experienced 6-11 m higher global sea levels. The role of Antarctica is vital for constraining sea-level projections. This Austra ....Back to the Future: Interglacial Warming and the West Antarctic Ice Sheet . The Antarctic is highly-sensitive to abrupt changes caused by the passing of tipping points within the climate system. Crucially, the instrumental record is too short to resolve major uncertainties surrounding future warming. The Last Interglacial (125,000 yrs ago) was 2°C warmer than today and experienced 6-11 m higher global sea levels. The role of Antarctica is vital for constraining sea-level projections. This Australian-led international project aims to determine the mechanisms and impacts of past interglacial Antarctic warming up to 2°C (relative to pre-industrial). Innovative techniques integrating horizontal ice cores and high resolution marine records will help identify polar tipping points and better plan for impacts in Australia.Read moreRead less
Restorative Justice and Responsive Regulation. The objective of this research is through a series of projects to bring the autor's restorative justice and responsive regulatin research programs of the last decade together, to intergrate them. this means to bear a restorative and responsive approach to transforming the entire legal system, not just criminal or regulatory law/administration. hwever, it does also mean reforming criminological theory with regulatory theory and applying restorative ....Restorative Justice and Responsive Regulation. The objective of this research is through a series of projects to bring the autor's restorative justice and responsive regulatin research programs of the last decade together, to intergrate them. this means to bear a restorative and responsive approach to transforming the entire legal system, not just criminal or regulatory law/administration. hwever, it does also mean reforming criminological theory with regulatory theory and applying restorative justice to business regulation, as well as tort, tax, contract and all areas of law.Read moreRead less
RNAi Therapeutic Intervention Of Human Viral Respiratory Disease
Funder
National Health and Medical Research Council
Funding Amount
$584,117.00
Summary
Human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. HMPV is emerging as a major cause of morbidity and life-threatening respiratory tract disease in infants, young children and the elderly worldwide. No treatment is currently available. The objectives of this proposal are to develop novel antiviral drugs that silence the expression of viral genes and to examine protection against the disease.
Mechanism/s Of Disease Caused By Respiratory Viral Infections
Funder
National Health and Medical Research Council
Funding Amount
$479,517.00
Summary
A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract ill ....A newly discovered respiratory virus, human metapneumovirus (HMPV), causes clinical disease that is very similar to human respiratory syncytial virus (RSV) and co-circulates with RSV. Human RSV is a major cause of morbidity and life-threatening respiratory tract disease in infants and young children worldwide, and is recognised as an important respiratory pathogen in elderly adults and immune compromised patients. The recent isolation of HMPV from children hospitalised with respiratory tract illness similar to RSV, but with an unknown etiology, suggests that HMPV may mediate similar clinical pathology. Nothing is currently known about the immune response to HMPV, or the association of these responses with lung disease. The objectives of this proposal are to elucidate the mechanisms of immunity and disease pathogenesis associated with human metapneumovirus (HMPV) and to investigate the use of a novel vaccine to protect against HMPV infection. Once this data is obtained, the study will provide the foundation for further research in the development of vaccines or therapeutic protocols to treat HMPV. It will also provide valuable information for understanding the disease in humans. Also,it is likely that HMPV, like hRSV, may prove to be an agent associated with long-term decreased pulmonary function and airflow limitation perhaps developing to asthma.Read moreRead less
Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data stream ....Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data streams. This project will use high-resolution global and regional ocean/sea-ice models to examine mechanisms for rapid warming of Antarctic continental shelf waters via both large-scale drivers and fine-scale processes, including mesoscale eddies, tide-topography interactions, and bottom boundary flows. This work will better constrain future rates of ice melt around Antarctica by providing vital knowledge of the ocean processes, dynamics, and feedbacks relating to warm water intrusion onto the Antarctic continental shelf.Read moreRead less
The Governance of Defiance. Defiance is a threat to social order. For this reason sanctioning institutions are in place to punish the defiant through legal, financial and sometimes physical means. The institutional rationale is that, at worst defiance will be silenced and at best, compliance will take its place. Increasingly, adverse and unexpected consequences of dealing with defiance in this way have been exposed. To be accountable for their actions, therefore, authorities have begun to develo ....The Governance of Defiance. Defiance is a threat to social order. For this reason sanctioning institutions are in place to punish the defiant through legal, financial and sometimes physical means. The institutional rationale is that, at worst defiance will be silenced and at best, compliance will take its place. Increasingly, adverse and unexpected consequences of dealing with defiance in this way have been exposed. To be accountable for their actions, therefore, authorities have begun to develop more responsive and deliberative systems. But they also need to know how to read defiance. When is defiance an inappropriate response to a more than reasonable request? And when is defiance a reflection of institutional failure? This project can inform such decision making.Read moreRead less