The Role Of Novel G-Protein Coupled Receptors In Immunity And Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$69,684.00
Summary
Recent advances in molecular biology techniques have resulted in the identification of many novel GPCRs. Novel GPCRs expressed selectively on immune cells display a potential target for novel therapies for inflammatory diseases such as Asthma and Rheumatoid arthritis. This project aims to define the activity and significance of a novel group of GPCRs, the GPR40 family. Outcomes of this project will be further understanding of immune cell development and inflammatory disease development.
Studies Of The Effects Of Asymmetric Hearing Loss On The Brain
Funder
National Health and Medical Research Council
Funding Amount
$920,076.00
Summary
Hearing loss impairs the normal development and maintenance of auditory pathways. Irreversible pathologies persist when hearing is not restored in a timely manner. While cochlear implantation is the accepted treatment for profound sensorineural hearing loss, there is significant variability in outcomes. Some of this variability is linked to the degree of hearing asymmetry. Thus, we propose to study brain changes in the auditory system that accompany asymmetric hearing impairment.
Modifiable Risks And Interventions For Cognitive Decline, Depression And Dementia In Older People
Funder
National Health and Medical Research Council
Funding Amount
$430,055.00
Summary
This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors pr ....This research proposal will explore the modifiable risk factors for cognitive decline (ie. changes in memory and thinking functions) in older people. It will examine the pertinence of critical contributors to glial-neuronal networks including depression, cardiovascular disease, sleep-wake systems, mental and physical exercise, inflammatory processes and diet, as well as test interventions that target these risk factors. It will use sophisticated brain scanning methods to examine which factors promote neuroplasticity.Read moreRead less
Visual Simultaneous Localisation and Mapping in Deformable Environments. This project aims to investigate the problem of building a three-dimensional map of a deformable environment in real-time using images and at the same time localising the camera within the map. This project expects to generate new knowledge in the area of simultaneous localisation and mapping in deformable environments using visual sensors. Expected outcomes include in-depth understanding of the fundamental sensing requirem ....Visual Simultaneous Localisation and Mapping in Deformable Environments. This project aims to investigate the problem of building a three-dimensional map of a deformable environment in real-time using images and at the same time localising the camera within the map. This project expects to generate new knowledge in the area of simultaneous localisation and mapping in deformable environments using visual sensors. Expected outcomes include in-depth understanding of the fundamental sensing requirements for the problem to be solvable, the achievable accuracy, and efficient algorithms for achieving accurate three-dimensional reconstruction of deformable environments. The research outcomes from this project offer significant benefits to diverse areas such as minimally invasive robotic surgery.Read moreRead less
Robotic Perception with Unconventional Sensors . Autonomy in robotic systems currently relies on conventional sensors such as lasers and cameras. Alternative sensing modalities as in the case of active electromagnetic sensors are commonly used to detect flaws, cracks and assess infrastructure’s integrity, however, fundamental research questions preclude their use for robotic perception. This project will develop the theory and algorithms to enable perception tasks such as localisation, mapping a ....Robotic Perception with Unconventional Sensors . Autonomy in robotic systems currently relies on conventional sensors such as lasers and cameras. Alternative sensing modalities as in the case of active electromagnetic sensors are commonly used to detect flaws, cracks and assess infrastructure’s integrity, however, fundamental research questions preclude their use for robotic perception. This project will develop the theory and algorithms to enable perception tasks such as localisation, mapping and recognition with unconventional sensors. The outcomes of this research have the potential to improve the effectiveness of critical civil infrastructure maintenance technology through accurate and reliable inspections, and the reduced need for human intervention.Read moreRead less
Development of globally optimal solutions to simultaneous localisation and mapping for robot navigation. Building robots that can operate on their own is one of the potentially transformational technologies of this century. This project will develop algorithms that are well understood and robust to allow the deployment of robots in environments populated with people and in search and rescue operations where global positioning system is not available.
Robotics for zero-tillage agriculture. This project will develop small agricultural robots to increase broad-acre crop production and reduce environmental impact. These robots will have advanced navigation capability, will cooperate to cover large areas and resupply themselves, while causing less soil damage and applying herbicide more intelligently.
Disassembly Automation of End-of-Life Electric Vehicle Batteries. This project aims to develop an automated disassembly solution for End-of-Life (EOL) Electric Vehicle (EV) batteries, which is flexible and modular to handle the uncertainties associated with model changes, condition of the EOL battery packs as well as the projected volume growth. The outcome of this project will lead to a better separation of EV battery components and materials. This will allow recycling of EOL EV batteries with ....Disassembly Automation of End-of-Life Electric Vehicle Batteries. This project aims to develop an automated disassembly solution for End-of-Life (EOL) Electric Vehicle (EV) batteries, which is flexible and modular to handle the uncertainties associated with model changes, condition of the EOL battery packs as well as the projected volume growth. The outcome of this project will lead to a better separation of EV battery components and materials. This will allow recycling of EOL EV batteries with a higher material recovery efficiency and a lower cost due to the significantly reduced labor cost; hence substantially reduce the environmental footprint associated with EOL treatment of these batteries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100068
Funder
Australian Research Council
Funding Amount
$931,950.00
Summary
Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under ....Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under environmental stress; integral chemical signals exchanged in host-microbe interactions; and volatile signatures linked to ecosystem health and developmental anomalies in animals. Results will inform innovative strategies to enhance biological adaptation, climate resilience and plant, animal, and ecosystem health.Read moreRead less
Learning and planning with qualitative models. This project will give a robot the ability to learn how to interact with its environment, using common sense reasoning to guide trial-and-error learning. The outcome will be a robot that is able to quickly adapt to new and changing environments, such as those which might be encountered in applications like robots for urban search and rescue.