The Contribution Of Maternal Obesity And Gestational Weight Gain To Preschool Child Obesity
Funder
National Health and Medical Research Council
Funding Amount
$697,213.00
Summary
Obesity affects more than 43 million children 0-5 years world-wide, and 21% of Australian children 2-3 years of age. The intra-uterine environment plays a key role in the development of later health and disease, representing a critical period in the subsequent programming of obesity. We will evaluate health outcomes (including growth/adiposity) for infants at 3 years, whose mother’s participated in a randomised trial evaluating an antenatal dietary intervention to limit gestational weight gain.
Metformin And Dietary Advice To Improve Insulin Sensitivity And Promote Gestational Restriction Of Weight In Pregnant Women Who Are Obese: The GRoW Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,710,437.00
Summary
Obesity is a significant health issue during pregnancy and childbirth associated with well documented risks. Women who are obese commence pregnancy in a state of increased insulin resistance, the altered metabolic and inflammatory environment providing an excess of nutrients, and a stimulus to fetal growth. The aims of the GRoW randomised trial are to evaluate the effects of metformin and dietary advice to improve insulin sensitivity in obese pregnant women on health outcomes.
Inflammatory Mediators Of Liver Injury In Chronic Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$349,336.00
Summary
Presently, liver disease from chronic hepatitis C and obesity represents a major health problem. Overall, approximately 50% of Australians with chronic hepatitis C are obese and these patients are at significantly increased risk of rapidly progressing to liver failure. It is now recognized that fat derived factors play an important role in regulating inflammatory responses. This grant proposal aims to gain insight into how liver and fat derived inflammatory factors interact to promote increased ....Presently, liver disease from chronic hepatitis C and obesity represents a major health problem. Overall, approximately 50% of Australians with chronic hepatitis C are obese and these patients are at significantly increased risk of rapidly progressing to liver failure. It is now recognized that fat derived factors play an important role in regulating inflammatory responses. This grant proposal aims to gain insight into how liver and fat derived inflammatory factors interact to promote increased liver damage in chronic hepatitis C and obesity.Read moreRead less
Genetic And Early Life Predictors Of Ectopic Fat And Their Association With Cardiometabolic Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,706,136.00
Summary
Obesity in childhood predicts adult cardiovascular disease. Body mass index as a measure of obesity does not fully describe the biology of excess adiposity. However, differences in the distribution of body fat, particularly fat around organs, may explain some of the excess risk. We will examine effects of genetic, pregnancy and childhood factors on different body fats and cardiovascular risk in Raine Study participants at 26 years. These young adults have been studied from pregnancy to adulthood
Control Of Neuropeptide FF Receptors On Appetite And Energy Homeostasis
Funder
National Health and Medical Research Council
Funding Amount
$609,281.00
Summary
Despite the alarming obesity epidemic, there currently exists no effective long-term treatment for obesity. Neuropeptide FF and its receptor NPFF2R have an emerging role in regulating food intake and body fat stores. Results from this study will show whether NPFF2R plays an important role in regulating appetite, metabolic rate, body weight and fat stores, thus help to identify whether NPFF2R-targeted therapeutics would confer significant benefit for the long-term treatment of obesity.