Automatic detection and modelling of acoustic markers of speech timing. This project aims to create new automatic sensing, analysis and assessment of cognitive, affective, mental and physical state from voice for mobile and computing devices. This project expects to generate new understanding of the effects of these states on detailed timing indicators of speech motor control, and new signal processing and machine learning methods that best exploit it. Expected outcomes from this project include ....Automatic detection and modelling of acoustic markers of speech timing. This project aims to create new automatic sensing, analysis and assessment of cognitive, affective, mental and physical state from voice for mobile and computing devices. This project expects to generate new understanding of the effects of these states on detailed timing indicators of speech motor control, and new signal processing and machine learning methods that best exploit it. Expected outcomes from this project include a new and accurate deep neural network framework for learning, analysing and detecting human states from speech automatically using articulatory timing markers. This should provide significant benefits, such as individually-tailored, frequent and low-cost automatic detection, monitoring and analytics for adverse states.Read moreRead less
The Biology Of Risk For Bipolar Disorder: Genetic Effects In A High-risk Longitudinal Study
Funder
National Health and Medical Research Council
Funding Amount
$856,412.00
Summary
Bipolar disorder is a severe mood disorder affecting over 350,000 Australians. Some children of bipolar disorder patients will also become ill, although currently we have no tools to predict which of these genetically at-risk young individuals will eventually develop symptoms. This study will use genetic information plus brain structural changes to predict which at-risk individuals are likely to become ill. This study will help elucidate early clinical and biological markers of bipolar disorder.
Robots as a Social Group: Implications for Human-Robot Interaction. This Project aims to identify psychological factors that can limit the acceptance of robots in the home and workplace. As robots become more pervasive in everyday life, they are also likely to elicit fear, rejection, and even damage. The significance of the Project lies in its social neuroscientific approach to promoting better human-robot interaction by considering robots as a social group. Expect outcomes include theory develo ....Robots as a Social Group: Implications for Human-Robot Interaction. This Project aims to identify psychological factors that can limit the acceptance of robots in the home and workplace. As robots become more pervasive in everyday life, they are also likely to elicit fear, rejection, and even damage. The significance of the Project lies in its social neuroscientific approach to promoting better human-robot interaction by considering robots as a social group. Expect outcomes include theory development about human and robot intergroup acceptance, enhanced institutional and international collaborations, and much needed psychological knowledge for robot designers. Benefits include a detailed understanding of how to increase the acceptance of robots in a wide variety of fields.Read moreRead less
Rapidly giving intravenous fluid to prevent or treat shock (fluid resuscitation) is one of the commonest treatments given to critically ill patients. Current guidelines recommend crystalloid solutions but it is unknown whether any particular crystalloid is better than others. This trial will determine whether the use of one of two crystalloid fluids, saline or PlasmaLyte, reduces the risk of organ injuries, such as kidney failure, and improves patients chances of surviving critically illness.
Social buffering of fear inhibition in adolescent rats. Adolescence is an important time when individuals learn to manage stress-related emotions like fear. Peers can help, or hinder, individuals to regulate fear. This project aims to understand how, when, and for whom social buffering of fear regulation occurs during adolescence. It uses a behavioural, pharmacological, and neural approach to explore these issues. The project aims to close the gap in understanding of how social companions affect ....Social buffering of fear inhibition in adolescent rats. Adolescence is an important time when individuals learn to manage stress-related emotions like fear. Peers can help, or hinder, individuals to regulate fear. This project aims to understand how, when, and for whom social buffering of fear regulation occurs during adolescence. It uses a behavioural, pharmacological, and neural approach to explore these issues. The project aims to close the gap in understanding of how social companions affect basic learning and memory processes in an understudied population of adolescents. The expected outcomes of this project include a richer knowledge of how peers shape emotional regulation during development, which will ultimately inform social-based approaches for improving emotion regulation in youth.
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Improving The Cardiometabolic Health Of People With Psychosis: The Physical Health Nurse Consultant Service
Funder
National Health and Medical Research Council
Funding Amount
$667,021.00
Summary
People with psychosis have high rates of chronic disease that reduces lifespan by 25 years. The health system struggles to provide adequate care. We developed the Physical Health Nurse Consultant service that provides physical health care coordination and will evaluate whether it improves physical health, consumer experience and cost-effectiveness. Outcomes will directly address policy initiatives to improve physical health service delivery in mental health services.
Selective Estrogen Receptor Modulators (SERMs) - A Potential New Treatment For Women Of Child-bearing Age With Psychotic Symptoms Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$210,480.00
Summary
Schizophrenia is a devastating illness urgently requiring a new treatment approach. We have discovered that estrogen is an effective treatment for women with schizophrenia and are currently trialling a safer Selective Estrogen Receptor Modulator (SERM) known as brain estrogen� in postmenopausal women with schizophrenia. Regulatory permission is now available to trial the SERM in younger women, and we seek to extend our current SERM study into child bearing age women with schizophrenia.
Improving The Mental Health Outcomes Of People With Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$1,189,979.00
Summary
Australians with intellectual disability (ID) have very high rates of mental illness but experience very poor access to mental health services. Our research will develop a sound evidence base on the profile of mental ill health, service use, pathways to care and mental health policy for people with intellectual disability. Together with consumers and support persons we will examine ways to improve mental health services for people with intellectual disability.
From Brain Maps To Mechanisms: Modeling The Pathophysiology Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
My Fellowship will develop a framework that integrates brain imaging data with mathematical models of the brain to help understand the mechanisms responsible for schizophrenia. By linking functional Magnetic Resonance Imaging (fMRI) measurements to models of their underlying causes, the work may lead to new treatments that target the specific dysfunction in individuals with this debilitating brain disorder.
A Randomised Control Trial Of Non-specific Clinical Management Versus CBT In Chronic Anorexia Nervosa
Funder
National Health and Medical Research Council
Funding Amount
$555,843.00
Summary
Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in ....Anorexia nervosa (AN) is a serious mental illness that usually starts in adolescence and often runs a chronic course. With an estimated prevalence rate between 0.5% and 3.7% of women, and up to 50% remaining chronically ill, the illness poses a disproportionate burden on health and social services. AN has inpatient costs alone that exceed that for schizophrenia. Chronic AN has the highest mortality rate of any mental illness. Chronic AN patients are known for their ambivalence about engaging in treatment and poor motivation to change their eating disorder behaviours. They often fail to respond to traditional treatments and develop a history of negative treatment experiences and repeated treatment failures. A new approach is needed to reduce both the personal suffering and the burden of the illness on social and medical services. To date, there has been little scientific investigation into the development of specific treatment for those patients with chronic AN. This study will trial a recently manualised therapy - non-specific supportive clinical management - which initial evidence suggests may hold promise for chronic AN because it offers a more indirect, motivationally-matched approach. This treatment will be compared to the establishment therapy Cognitive Behavioural Therapy. Patients will be randomly allocated to one of the two treatment conditions and will receive 40 sessions over 12 months. They will be thoroughly assessed prior to during and after they have completed treatment and followed up for 6 months. This is the worlds first trial of a psychological treatment for chronic AN; it is hoped the study will establish an effective treatment for this debilitating and expensive illness. Further, as the project aims to explore the core, but often over-looked, feature of AN - poor motivation for recovery - it will also be in a position to shed light on the deep psychological processes that maintain this illness.Read moreRead less