Discovery Early Career Researcher Award - Grant ID: DE150101518
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisel ....Cellular responses to nanoparticles from cells on micropatterned surfaces. The mechanisms underlying cell-nanoparticle interactions remain largely unknown. It has hampered the design and development of innovative nano devices to be used for drug delivery, biomarkers and diagnostics. This project aims to explore the influences of cell size, density, geometry, intercellular communication and substrate properties on cell-nanoparticle interactions. A micropatterning technology is applied to precisely control cell behaviour and provide a novel in vitro cellular model for nanoparticle studies. This project aims to significantly improve the understanding of cell-nanoparticle interactions to provide new insight into nanoparticle design and improve the efficacy of nano devices.Read moreRead less
Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which i ....Multimodal retinal imaging provides "insight" into cerebrovascular ageing. Multimodal retinal imaging provides "insight" into cerebrovascular ageing. This project aims to develop a multi-modal imaging technology platform to simultaneously measure amyloid beta and its neurovascular sequelae to identify novel early biomarkers of ageing in the eye and brain. The growing ageing population is an increasing socioeconomic burden. The central nervous system is particularly susceptible to ageing, which is difficult to measure at its onset. Critically, as the eye is an easily accessible extension of the cortex, retinal imaging may be a non-invasive surrogate to assess ageing changes in the brain. Anticipated outcomes are a sensitive detector of neural ageing, improved preventative measures, reducing the socioeconomic burden of ageing, and improved quality of life.Read moreRead less
Unleashing the potential of VR: reducing sickness in head-mounted displays. Virtual reality (VR) is a breakthrough technology with a host of applied uses. Unfortunately, many people become sick when using head-mounted displays (HMDs). Our project proposes, and aims to test, a new theory of this cybersickness. We intend to quantify the sensory conflicts produced by HMD VR for the first time and measure their effects on perception, eye-movements, balance and well-being. The project will 1) determi ....Unleashing the potential of VR: reducing sickness in head-mounted displays. Virtual reality (VR) is a breakthrough technology with a host of applied uses. Unfortunately, many people become sick when using head-mounted displays (HMDs). Our project proposes, and aims to test, a new theory of this cybersickness. We intend to quantify the sensory conflicts produced by HMD VR for the first time and measure their effects on perception, eye-movements, balance and well-being. The project will 1) determine the causes of, and conditions responsible for, cybersickness; and 2) offer practical information on how to prevent it. These outcomes are expected to directly benefit, and greatly improve HMD use in, fields ranging from defence, education, entertainment, gaming, medicine, real estate, simulation training and tourism.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100858
Funder
Australian Research Council
Funding Amount
$344,896.00
Summary
Human-Centred Robot Training. This project aims to address the challenge of effectively enabling novice users to train robots on complex tasks using instructional methods and gamification. With the recent advances of AI research, robots have now better cognitive and functional skills, research in robot training also now allows them to learn interactively from human. Since these robots are expected to provide assistance in different domains including education and healthcare, it is crucial to eff ....Human-Centred Robot Training. This project aims to address the challenge of effectively enabling novice users to train robots on complex tasks using instructional methods and gamification. With the recent advances of AI research, robots have now better cognitive and functional skills, research in robot training also now allows them to learn interactively from human. Since these robots are expected to provide assistance in different domains including education and healthcare, it is crucial to effectively engage human in robot’s instruction. Expected outcomes include new methods for trainers to assess robot learning, and to improve their engagement and feedback. This should provide significant human-robot interaction benefits for accessibility of learning robots.Read moreRead less
Determination of cellular mechanisms underpinning cancer cell metastasis through integrated in vivo imaging approaches. Understanding key steps that drive the spread of cancer is critical to improve current treatment strategies. Using cutting-edge imaging technology and in vivo model systems that mimic the disease, this project will pinpoint key events that are susceptible to drug intervention and identify new therapeutic targets.
Industrial Transformation Research Hubs - Grant ID: IH210100025
Funder
Australian Research Council
Funding Amount
$4,379,165.00
Summary
ARC Research Hub for Advanced Manufacturing with 2D Materials (AM2D). Australia holds large resources of critical 2D minerals – key enablers of several existing and emerging technologies in Energy Storage, Purification and Printed Electronics. The AM2D hub aims to provide a sophisticated environment for researchers and an industrial translation platform for manufacturers; a hub where leading academics, bright students, and industry partners come together to learn, apply, collaborate, innovate, a ....ARC Research Hub for Advanced Manufacturing with 2D Materials (AM2D). Australia holds large resources of critical 2D minerals – key enablers of several existing and emerging technologies in Energy Storage, Purification and Printed Electronics. The AM2D hub aims to provide a sophisticated environment for researchers and an industrial translation platform for manufacturers; a hub where leading academics, bright students, and industry partners come together to learn, apply, collaborate, innovate, and deliver industry transformation in advanced manufacturing. Anticipated outcomes include the transformation of newly discovered materials into globally traded, high-value 2D products, enabling Australian industries to capture more wealth and jobs from this large and growing market.
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Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolut ....Single molecule intracellular intravital imaging of actin dynamics. The project intends to develop imaging technology to visualise fundamental processes in cells within a living animal. The focus will be on the actin cytoskeleton, a dynamic macromolecular machine involved in key cellular processes including cell structure, mobility and division. It is exquisitely sensitive to environmental perturbations, requiring it to be studied in cells in living tissue. The project aims to extend the resolution of live imaging to the single molecule to understand the dynamics of actin assembly with implications for cellular processes that are hijacked in diseases. It also aims to provide a novel assay that may enable testing of the impact of drugs on cellular processes in real time.Read moreRead less
Machine Learning for Fracture Risk Assessment from Simple Radiography. This project aims to develop a novel, reliable, low-cost system to detect poor bone health and assess fracture risk to help to prevent and manage osteoporosis-related fractures. Currently, osteoporosis-related fractures cost our health system millions of dollars annually and costs are increasing with our ageing population. Early detection of poor bone health will improve the effectiveness of preventive measures and ease this ....Machine Learning for Fracture Risk Assessment from Simple Radiography. This project aims to develop a novel, reliable, low-cost system to detect poor bone health and assess fracture risk to help to prevent and manage osteoporosis-related fractures. Currently, osteoporosis-related fractures cost our health system millions of dollars annually and costs are increasing with our ageing population. Early detection of poor bone health will improve the effectiveness of preventive measures and ease this burden. Current methods include unreliable, crude clinical and visual guides that suggest osteoporosis screening. The project plans to develop a novel system by applying machine learning algorithms to radiology data which is commonly captured for diagnosing other conditions.Read moreRead less