Modelling The Interaction Between Sexually Transmitted Infections And HIV Transmission To Inform Public Health Policy
Funder
National Health and Medical Research Council
Funding Amount
$543,624.00
Summary
Other sexually transmitted infections (STIs) increase the risk of acquiring or transmitting HIV. Using mathematical models the population level effects of this increased risk will be investigated. This work will inform the design of effective and efficient STI treatment programs that aim to reduce the number of HIV infections in Australian gay men, prevent HIV epidemics in Aboriginal and Torres Strait Island communities, and slow the growth of HIV in Papua New Guinea.
Molecular Studies Of The Astrocyte Reservoir Of HIV-1 In The Central Nervous System
Funder
National Health and Medical Research Council
Funding Amount
$592,661.00
Summary
HIV infects the brain causing dementia in 10-20% patients. Strategies aimed at eradicating HIV infection fail to take into account CNS infection. Understanding the way in which HIV enters, infects and replicates in the brain is pivotal in development of drugs to prevent brain infection and dementia. Our studies have shown that HIV infection of the brain involves mechanisms distinct to those observed for blood and other organs. This study seeks to clarify such mechanisms.
Cell Type Specific Biologic Responses To HIV Infection
Funder
National Health and Medical Research Council
Funding Amount
$636,242.00
Summary
The way in which HIV alters the internal environment of its target cells to facilitate its growth will be examined. These changes enhance its ability to gain a toehold in the human body after entering the genital tract and its persistence for life in the brain and elsewhere in the body.
Assessing the national productivity impacts of chronic ill health. The project aims to address one of the biggest gaps in health and productivity research by designing a novel composite national metric that will rank lost productivity due to chronic illness The project brings together tax/transfer modelling, health modelling and epidemiological modelling specialists to develop a highly innovative microsimulation model: Health&WorkMOD to then quantify the costs of health-related productivity loss ....Assessing the national productivity impacts of chronic ill health. The project aims to address one of the biggest gaps in health and productivity research by designing a novel composite national metric that will rank lost productivity due to chronic illness The project brings together tax/transfer modelling, health modelling and epidemiological modelling specialists to develop a highly innovative microsimulation model: Health&WorkMOD to then quantify the costs of health-related productivity loss. The proposed model, an international first, will be a powerful tool to comprehensively model the cost impacts of illness and simulate policy options related to health and productivity. This will provide answers to critical policy questions for government with potential significant economic benefits.Read moreRead less
Interactions Between HIV And Mycobacterial Infections Of Macrophages Mediated By Changes In Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$119,625.00
Summary
HIV-AIDS and tuberculosis are two of the worlds most important diseases. HIV-AIDS is the fourth leading killing disease worldwide and tuberculosis is the leading opportunistic infection in patients with AIDS particularly in the developing world. Both microbes infect the same cell type, the macrophage, which is widely distributed throughout the body, particularly in lymph nodes and lung. Recent studies in humans have shown that HIV and TB like organisms stimulate each others growth. This study us ....HIV-AIDS and tuberculosis are two of the worlds most important diseases. HIV-AIDS is the fourth leading killing disease worldwide and tuberculosis is the leading opportunistic infection in patients with AIDS particularly in the developing world. Both microbes infect the same cell type, the macrophage, which is widely distributed throughout the body, particularly in lymph nodes and lung. Recent studies in humans have shown that HIV and TB like organisms stimulate each others growth. This study uses the immense power of DNA microarrays, based on the identification of almost all genes by the human genome project, to decipher the interactions between the two microbes. By following up new leads indicated by the microarrays, the way in which the microbes manipulate the macrophage to enhance their own growth and that of the other can be eventually deciphered. This will provide new strategies for future interventions. New drugs are urgently needed for both microbes.Read moreRead less
Understanding recent Australian trends in alcohol consumption and harms. This project aims to provide critical insight into recent trends in alcohol consumption and related harm in Australia. Many indicators of harm from alcohol have increased dramatically in the past decade, while drinking behaviours appear largely unchanged. This project aims to investigate two potential explanations for these trends: that apparent increases in rates of alcohol-related harm are driven by operational or adminis ....Understanding recent Australian trends in alcohol consumption and harms. This project aims to provide critical insight into recent trends in alcohol consumption and related harm in Australia. Many indicators of harm from alcohol have increased dramatically in the past decade, while drinking behaviours appear largely unchanged. This project aims to investigate two potential explanations for these trends: that apparent increases in rates of alcohol-related harm are driven by operational or administrative practices rather than by increases in actual harm; and that stable per-capita consumption data obscures divergent drinking behaviours, with increases among heavy drinkers driving increasing harm rates. The project aims to inform alcohol policy debates, which rely on robust trend data.Read moreRead less
Enhancing the Technology Transfer Capability of Australian Univerities. This project aims to assist in achieving enhanced University capability in technology transfer which is regarded by government as cruicial to improving national innovation performance. I seeks to identify the determinants of effective technology transfer and provide in-depth understanding of the social process involved in transferring both inventions and associated scientific knowledge from universities to corporationss. Emp ....Enhancing the Technology Transfer Capability of Australian Univerities. This project aims to assist in achieving enhanced University capability in technology transfer which is regarded by government as cruicial to improving national innovation performance. I seeks to identify the determinants of effective technology transfer and provide in-depth understanding of the social process involved in transferring both inventions and associated scientific knowledge from universities to corporationss. Employing a contingent effectiveness model, the research will focus on the characteristics of the transfer agent, the transfer recipient, the transfer medium, the transfer object and the demand environment. Results and recommended strategies will be communicated to university and industry managers and government officials.Read moreRead less
The role of a national human rights inquiry: impact on attitudes, research, policy and community development. This project will investigate the social impact of a Human Rights and Equal Opportunity Commission Inquiry in Australia: The Inquiry into Remote and Rural Education. It will seek to identify the processes and mechanisms through which such inquiries mediate between rural, state, national and international community expectations and demands and the extent to which they contribute to social ....The role of a national human rights inquiry: impact on attitudes, research, policy and community development. This project will investigate the social impact of a Human Rights and Equal Opportunity Commission Inquiry in Australia: The Inquiry into Remote and Rural Education. It will seek to identify the processes and mechanisms through which such inquiries mediate between rural, state, national and international community expectations and demands and the extent to which they contribute to social change. This is an innovative project that is attempting for the first time to evaluate whether and how such inquiries have been able to influence subsequent research in the area and contribute to changes in policy at national, state and local levels.Read moreRead less
Pathogenesis Of Persistent Human Virus Infections Of Global Significance
Funder
National Health and Medical Research Council
Funding Amount
$6,571,328.00
Summary
The study will investigate why humans cannot eradicate particular viruses (HIV-AIDS, cytomegalovirus and herpes simplex virus), the long term effects of these viruses and ways to improve control. Current treatments can only partly suppress the levels of these viruses, because they persist in certain parts of the body called reservoirs, only to resurge later causing disease. Thus, the overall aim of the research program is to discover the mechanisms by which these viruses are able to successfully ....The study will investigate why humans cannot eradicate particular viruses (HIV-AIDS, cytomegalovirus and herpes simplex virus), the long term effects of these viruses and ways to improve control. Current treatments can only partly suppress the levels of these viruses, because they persist in certain parts of the body called reservoirs, only to resurge later causing disease. Thus, the overall aim of the research program is to discover the mechanisms by which these viruses are able to successfully persist within reservoirs in the human body. The research program brings together a group of 6 leading scientists and clinicians located at 3 sites in 2 Australian cities. The team is comprised of experts in the study of HIV-AIDS, cytomegalovirus and herpes simplex virus who will combine their knowledge and expertise to speed up the process of research on these viruses that are of major health importance. Studies will also utilise a number of cutting edge technologies that now make it possible to much more rapidly and precisely determine how viruses cause disease. Advances in our understanding of how viruses persist may form the basis for treatments aimed at controlling persistent infections and the serious diseases caused by these viruses.Read moreRead less