Increased Airway Smooth Muscle Mass As An Independent Determinant Of Asthma Pathogenesis And Severity
Funder
National Health and Medical Research Council
Funding Amount
$409,966.00
Summary
Asthma is a major health burden to the community. The most common form of the disease is allergic asthma and it is thought that allergic inflammation drives associated airway abnormalities including increased airway smooth muscle (ASM) mass. This study tests a new hypothesis that airway abnormalities and allergy have separate origins but combine to produce allergic asthma, and it’s the individuals with the greatest amount of ASM who develop clinically severe asthma.
Investigating The Effects Of Macrolides On Excessive Synthesis And Secretion Of Airway Mucins Using Novel Ex Vivo And In Vivo Approaches
Funder
National Health and Medical Research Council
Funding Amount
$520,821.00
Summary
Many people have difficulty breathing because the airway tubes that move air in and out of their lungs are blocked by excessive amounts of sticky mucus. Our project will use new techniques developed in our laboratories to investigate whether a group of medicines called “macrolides” can prevent the excessive production and release of mucus in the airways, and thus be beneficial in treating asthma, and potentially other lung diseases.
Epithelial Drivers Of Neutrophil Plasticity In Early Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$849,462.00
Summary
Why airway inflammation becomes chronic so early in life for people with cystic fibrosis (CF) is unclear. This project will use the latest techniques to characterise immune cells found in airways of infants with CF and model in the laboratory how immune cells react to the CF airway. We will challenge CF airway cells with different bugs that can infect the lung, then see if the responses by CF airway cells can change the normal response of immune cells, triggering chronic disease.
Dynamic CFD Simulations and Scale-Up of Three-Phase Slurry Reactors for Gas-to-Liquid (GTL) Technology. The gas-liquid-solid flow patterns in three-phase slurry bubble column reactors will be studied using experiments and CFD. The effect of various reactor parameters will be studied to develop the scale-up heuristic for the slurry bubble column reactor. The Findings of this study will be used to optimise the reactor system for the offshore natural gas locations of Australia. A successful impleme ....Dynamic CFD Simulations and Scale-Up of Three-Phase Slurry Reactors for Gas-to-Liquid (GTL) Technology. The gas-liquid-solid flow patterns in three-phase slurry bubble column reactors will be studied using experiments and CFD. The effect of various reactor parameters will be studied to develop the scale-up heuristic for the slurry bubble column reactor. The Findings of this study will be used to optimise the reactor system for the offshore natural gas locations of Australia. A successful implementation of this project will bring a huge economic benefit to Australia by utilising the vast amount of remotely located and otherwise unusable stranded natural gas reserves. The project falls within one of National Research Priorities: An Environmentally Sustainable Australia.Read moreRead less
Methanol to diesel. Australia has large remote gas reserves which are not accessible to markets via pipeline and cannot be effectively utilised using liquefied natural gas technology. Fischer-Tropsch conversion of gas to liquid (GTL), being capital intense, is uneconomical for these stranded gas resources. This project will develop a new GTL technology to produce sulphur-free, clean combustion diesel. The outcomes of this research will be a frontier technology that allows more effective utilisat ....Methanol to diesel. Australia has large remote gas reserves which are not accessible to markets via pipeline and cannot be effectively utilised using liquefied natural gas technology. Fischer-Tropsch conversion of gas to liquid (GTL), being capital intense, is uneconomical for these stranded gas resources. This project will develop a new GTL technology to produce sulphur-free, clean combustion diesel. The outcomes of this research will be a frontier technology that allows more effective utilisation of Australian remote gas resources to meet rising global demand for transport fuels, adding enormous value to Australian natural resources and contributing to Building and Transforming Australian industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989180
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Facility for studying the sorption properties of gases by nanostructured materials. The climate debate has put the issues that this research will address at the forefront of community concern. All of the initiatives discussed herein are relevant to alternative energy sources and greenhouse gas reduction. The facility will ensure that the research undertaken will be internationally cutting edge and will hasten the adoption of technologies that will flow from the research, thereby reducing the e ....Facility for studying the sorption properties of gases by nanostructured materials. The climate debate has put the issues that this research will address at the forefront of community concern. All of the initiatives discussed herein are relevant to alternative energy sources and greenhouse gas reduction. The facility will ensure that the research undertaken will be internationally cutting edge and will hasten the adoption of technologies that will flow from the research, thereby reducing the effects of the impending energy crisis and related global pollution issues. The current capability for accurately measuring gas sorption in materials for storage and sequestration is limited in W.A. and the proposed facility will address this situation.Read moreRead less
Development of a Novel One Step Process for Gas Conversion to Liquid. Australia has a rich natural gas reserve, most of which is in remote locations. This project will lead to a new technology to use the remote gas that would be flared into the atmosphere, thus benefiting both Australian economy and green house gas reduction. It will also reduce the risk of relying on importing oil from Overseas thus contributing to Australia's energy security. In addition, while crude-based oil emits SOx, NOx a ....Development of a Novel One Step Process for Gas Conversion to Liquid. Australia has a rich natural gas reserve, most of which is in remote locations. This project will lead to a new technology to use the remote gas that would be flared into the atmosphere, thus benefiting both Australian economy and green house gas reduction. It will also reduce the risk of relying on importing oil from Overseas thus contributing to Australia's energy security. In addition, while crude-based oil emits SOx, NOx and particulates etc into air, the liquid fuels from gas are pure and burns cleanly thus also contributing to air pollution control. Read moreRead less
Fundamental Data and Thermodynamic Modelling for Cryogenic LNG Fluids to Improve Process Design, Simulation and Operation. This research will contribute to a more environmentally sustainable Australia because it will promote the use of natural gas as a fuel supply which produces significantly fewer greenhouse gases than oil or coal. This project will improve the ability of engineers to reliably simulate LNG production plants as well as test new processes and technologies with the potential to in ....Fundamental Data and Thermodynamic Modelling for Cryogenic LNG Fluids to Improve Process Design, Simulation and Operation. This research will contribute to a more environmentally sustainable Australia because it will promote the use of natural gas as a fuel supply which produces significantly fewer greenhouse gases than oil or coal. This project will improve the ability of engineers to reliably simulate LNG production plants as well as test new processes and technologies with the potential to increase efficiency or revenue. Consequently, the level of over-engineering and, thus, the capital and operational costs of such plants will decrease. This in turn will promote the development of Australian gas reserves, particularly for those fields currently on the margins of economic viability.Read moreRead less
The Identification Of Thoracic Targets For Prevention And Intervention In Bronchopulmonary Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The persistence of breathing problems from infancy to later life is a complication of premature birth with lifelong consequences. Breathing problems often occur together with lung disease, but prematurity can also affect heart and blood vessel development, and weakness of the main breathing muscle. We will find out how much the heart, lungs and diaphragm contribute to breathing problems in babies; helping us to better predict, diagnose and treat severe breathing problems in babies born preterm.
Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in ....Hydrodynamics of Bubble Column Reactors. This project will study the hydrodynamics of bubble columns with the aim of optimising these reactors for offshore gas-to-liquid plants. Along with experiments using the state-of-art techniques such as the particle image velocimetry, radioactive particle tracking, electrical capacitance tomography and optical probes, computational fluid dynamics simulations will be conducted to gain a deeper insight into bubble-induced turbulence and regime transitions in these reactors. This information will then be used to devise scale-up strategies of these complex and industrially important equipment.Read moreRead less