A New, Low-cost E-health Treatment For Alcohol Use Disorder Using Mental Imagery
Funder
National Health and Medical Research Council
Funding Amount
$895,032.00
Summary
This project offers the first large-scale test of phone-based Functional Imagery Training (FIT), a new, low-cost way to help people change behaviours using mental imagery, regardless of where they live. The trial addresses Alcohol Use Disorder—a common problem with substantial health and social impacts, comparing FIT with verbal motivational treatments, and testing effects on alcohol use and quality of life over 12 months. Cost-effectiveness and predictions of outcome are also examined.
In pilot studies, we have found that specific genes are modulated by long-term alcohol intake in a discrete part of the brain that drives habitual behaviours. We will now repeat these studies in post-mortem brain tissue from human alcoholics and age-matched controls. In addition, we will further characterise the functional consequences of long-term alcohol intake within this specific brain region and test new approaches to reduce the urge to consume alcohol.
Substance abuse is a significant social and economic burden upon Australian societies and on societies around the world. Treatment remains problematic due to the multi-layer nature of the disease, difficulties with treatment compliance and less than ideal treatment regimes. The present study aims to improve treatments for alcohol and drug abuse using pre-clinical models to identify and characterize a new brain system implicated in drug-seeking.
Cross-national Comparison Of Influences For The Development Of Harmful Young Adult Alcohol Use
Funder
National Health and Medical Research Council
Funding Amount
$571,737.00
Summary
Although young adulthood is a time of high alcohol problems, there is cross-national variation in rates of problems and policy responses. This project will survey age 24 adults in Washington State in the USA in 2013-14 that were initially recruited in 2002 (aged 13) and annually resurveyed at ages 14 and 15. The sample has been matched to enable comparison of behaviours and longitudinal influences to an equivalent longitudinal cohort being followed in Victoria, Australia (Combined N = 1,556).
Estimating The Contribution Of Adolescent Alcohol Misuse Prevention To The Reduction Of Alcohol-related Harm In Australia
Funder
National Health and Medical Research Council
Funding Amount
$1,813,958.00
Summary
This project will extend an existing national randomised trial (comparing 14 intervention and 14 control communities) to complete a novel evaluation of the longer-term benefits of community-based adolescent alcohol use prevention to reduce population rates of adolescent alcohol use by at least 15%. The project will have significant policy implications in being the first to measure the health, social and economic benefits that flow from reducing population rates of adolescent alcohol use.
Oxytocin As A Novel Antagonist Of The Intoxicating And Addictive Effects Of Alcohol
Funder
National Health and Medical Research Council
Funding Amount
$739,106.00
Summary
Alcohol is Australia’s most harmful recreational drug and more effective treatments for alcohol abuse are desperately needed. The CIs have shown that administering oxytocin reduces alcohol intoxication and consumption, and prevents alcohol from acting at specific sites in the brain that are central to alcohol’s intoxicating and addictive effects. This project probes the effects of oxytocin at these sites and the potential utility of targeting this interaction to treat alcohol-use disorders.
The Relationship Between Accident Culpability And Drug Presence In Blood Samples Taken From Persons Injured In Motor Vehicle Collisions.
Funder
National Health and Medical Research Council
Funding Amount
$200,721.00
Summary
This project aims to determine the incidence of drugs in blood samples taken under the Victorian Road Safety Act 1986 from drivers involved in non-fatal collisions, the relative importance of illicit drugs, legal drugs used as prescribed, and legal drugs misused by drivers in non-fatal collisions by examining driver culpability in these accidents.
Defining The Clinical Role Of Topiramate In The Treatment Of Alcohol Dependence In Australia
Funder
National Health and Medical Research Council
Funding Amount
$718,836.00
Summary
We urgently require new strategies for the treatment of alcohol dependence. The effectiveness of currently approved alcohol medications is limited. Emerging data suggests that topiramate has robust effectiveness and that better medicine selection is possible for patients based on their genotype. We propose to conduct a double-blind randomised controlled trial to examine the clinical and cost effectiveness of topiramate using a genetically based personalised approach.
Increasing Uptake Of Evidence-based Management Of Unhealthy Alcohol Use In Aboriginal Primary Health Care Services
Funder
National Health and Medical Research Council
Funding Amount
$2,252,322.00
Summary
Because of ongoing trauma, stress and disadvantage, Aboriginal and Torres Strait Islander (Indigenous) Australians face a greater risk of unhealthy drinking patterns and related harms than other Australians. Yet there is a shortage of specialist alcohol treatment services. This study examines an approach to supporting primary care services which target Indigenous Australians to identify and implement the best possible standard of diagnosis and treatment for unhealthy alcohol use.
Parental Supply Of Alcohol To Children: Associations With Early Adult Health – “binge” Drinking, Alcohol-related Harms, Aggression, And Alcohol Use Disorders
Funder
National Health and Medical Research Council
Funding Amount
$1,143,477.00
Summary
We will investigate of the impacts of parental supply of alcohol between 13-18 years, on early adult alcohol use (19-23 years). We will follow an existing cohort of ~1,810 parent-child dyads, and assess the development of alcohol use, disorders, harms and aggression. We will investigate the impacts of: parental supply of sips vs drinks; supervised vs unsupervised supply; and modifying effects of contexts of supply and mediators (such as peer, child factors, etc.) controlling for confounders.