Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
Determining the sequence of events during eukaryotic translation initiation. Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is c ....Determining the sequence of events during eukaryotic translation initiation. Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is central to modern life sciences and its application to medical and biotechnological problems. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
Reactive oxygen species generation by zerovalent silver nanoparticles; implications to toxicity and contaminant degradation. Nanoparticulate silver is now being used for the purification of drinking water yet many questions remain concerning its mode of purifying action. Here we investigate the generation of reactive oxygen species (ROS) by nanoparticulate silver and examine the relationship between ROS generation and the purifying action of "nano-silver".
Measuring the impact of urban regulation on housing affordability in Australian cities and regions. Urban planning must ensure that development meets new environmental goals, but stringent regulation may reduce housing supply and affordability. This project uses new local planning data and econometric studies to quantify and monitor planning regulation impacts on housing supply and affordability in Australian cities and regions.
Shadow care infrastructures: sustaining life in the post-welfare city. Mounting evidence points to difficulties faced by Australians reliant on government income support in meeting market costs of essential needs. This project investigates whether and how ‘shadow care infrastructures’ – a wide range of formal and informal material and social supports – enable the survival, well-being and flourishing of income support recipients. Focusing on people with disabilities, unemployed and asylum seekers ....Shadow care infrastructures: sustaining life in the post-welfare city. Mounting evidence points to difficulties faced by Australians reliant on government income support in meeting market costs of essential needs. This project investigates whether and how ‘shadow care infrastructures’ – a wide range of formal and informal material and social supports – enable the survival, well-being and flourishing of income support recipients. Focusing on people with disabilities, unemployed and asylum seekers, the study evaluates the benefits and harms such infrastructures produce for those receiving and providing care, and the wider community. It examines risks and opportunities to scale up emerging care infrastructures identified as critical to making ends meet for income support recipients in contemporary cities.Read moreRead less
Reactive oxygen species production on oxygenation of subsurface sediments. This project aims to examine the nature, extent and effect of redox processes in subsurface environments. Reactive oxygen species, including hydrogen peroxide, superoxide and hydroxyl radicals, transform and affect redox-active substances in the environment such as arsenic, uranium and natural organic matter (which may be oxidised to carbon dioxide). Production of significant quantities of reactive oxygen species on oxyge ....Reactive oxygen species production on oxygenation of subsurface sediments. This project aims to examine the nature, extent and effect of redox processes in subsurface environments. Reactive oxygen species, including hydrogen peroxide, superoxide and hydroxyl radicals, transform and affect redox-active substances in the environment such as arsenic, uranium and natural organic matter (which may be oxidised to carbon dioxide). Production of significant quantities of reactive oxygen species on oxygenation of subsurface sediments through actions such as aquifer recharge and high flow events may alter the form and mobility of trace elements and influence the cycling of carbon and eventual efflux of carbon dioxide to the atmosphere. This project will examine the nature, extent and effect of these redox processes in selected subsurface environments. This research could have implications for contaminant transformation and fate and carbon cycling.Read moreRead less
Grandparent childcare: negotiating work and care across generations. This project aims to investigate how and why parents and grandparents share childcare responsibilities in contemporary Australia. Using mixed methods and an innovative conceptual approach with a central focus on parent-grandparent care dyads, it expects to generate critical new knowledge of intra-family negotiations about employment and childcare provision across generations, and their relationship with social and economic poli ....Grandparent childcare: negotiating work and care across generations. This project aims to investigate how and why parents and grandparents share childcare responsibilities in contemporary Australia. Using mixed methods and an innovative conceptual approach with a central focus on parent-grandparent care dyads, it expects to generate critical new knowledge of intra-family negotiations about employment and childcare provision across generations, and their relationship with social and economic policy. The project expects to identify sustainable employment-childcare practices that meet the needs of children, parents and grandparents. Significant benefits include informing new policies aimed to enhance both gender and generational equity, promote women’s workforce participation, and boost national productivity.Read moreRead less
Artificial Intelligence, Robots, and Agriculture: Social and ethical issues. This project aims to investigate the social and ethical issues raised by the use of artificial intelligence and robotics in agriculture. By combining social science research methods and philosophical analysis, the project aims to generate new knowledge in bioethics and applied ethics. Expected outcomes of this project include an account of the social and ethical issues farmers, rural communities, and consumers anticipat ....Artificial Intelligence, Robots, and Agriculture: Social and ethical issues. This project aims to investigate the social and ethical issues raised by the use of artificial intelligence and robotics in agriculture. By combining social science research methods and philosophical analysis, the project aims to generate new knowledge in bioethics and applied ethics. Expected outcomes of this project include an account of the social and ethical issues farmers, rural communities, and consumers anticipate arising from these technologies, improved understanding of these issues, and an account of how these groups would like to see these issues addressed. This should help Australia benefit from the responsible use of artificial intelligence and robotics in agriculture.Read moreRead less
The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically ....The effect of wastewater treatment on the ecotoxicity of chiral chemicals. This project aims to assess the environmental implications of pharmaceuticals discharged in effluents from wastewater treatment plants. Trace levels of human pharmaceuticals occur in sewage and urban waterways, but during sewage treatment, some pharmaceuticals can undergo a chemical transformation known as 'chiral inversion'. In some cases, this may convert relatively benign environmental contaminants to more ecologically toxic species. This project will investigate why and how some pharmaceuticals become susceptible to chiral inversion and assess ecotoxicological differences. This work is expected to determine the significance of considering chiral inversion in environmental risk assessment, with applications to a broader range of chemicals including pesticides and industrial chemicals.Read moreRead less
Reassembling the city: understanding resident-led collective property sales. This project aims to investigate the emerging phenomenon of residential collective sales - where neighbours come together to sell their properties in one line - and the implications for urban residents and governments at local, metropolitan and national levels. It intends to provide the first ever detailed empirical analysis of this phenomenon, including mapping, case studies and stakeholder and expert interviews across ....Reassembling the city: understanding resident-led collective property sales. This project aims to investigate the emerging phenomenon of residential collective sales - where neighbours come together to sell their properties in one line - and the implications for urban residents and governments at local, metropolitan and national levels. It intends to provide the first ever detailed empirical analysis of this phenomenon, including mapping, case studies and stakeholder and expert interviews across Sydney and Vancouver, two cities at the forefront of collective sales activity. The project aims to make significant contributions to both policy and academic debates, by advancing knowledge on how shifting dynamics of neighbourhood change will affect the planning and development of global compact cities in the 21st century.Read moreRead less