Digital Death and Immortality. This project will create a philosophically-informed ethical approach for managing the 'digital remains' of internet users who have died. Emerging artificial intelligence technologies make it possible to reuse and interact with these digital remains. This offers new ways of commemorating the dead and for managing grief. Yet these technologies also threaten to exploit the dead and to change our relationship to them in troubling ways. Expected outcomes of the project ....Digital Death and Immortality. This project will create a philosophically-informed ethical approach for managing the 'digital remains' of internet users who have died. Emerging artificial intelligence technologies make it possible to reuse and interact with these digital remains. This offers new ways of commemorating the dead and for managing grief. Yet these technologies also threaten to exploit the dead and to change our relationship to them in troubling ways. Expected outcomes of the project include guidance for the ethical use of these technologies and policy recommendations for regulating the reuse of digital remains. This will provide significant benefits by helping Australia to avoid the ethical dangers inherent in emerging technologies of 'digital reanimation.'Read moreRead less
Work Experience: Labour Law at the Intersection of Work and Education. This project aims to examine the regulatory challenges relating to post-secondary work experience, such as internships, in the areas of labour and employment, anti-discrimination and workers compensation law in Australia. The analysis is designed to establish a global and comparative context, examining policy and regulatory responses in Canada, Europe (including Britain), New Zealand, and the United States of America and at t ....Work Experience: Labour Law at the Intersection of Work and Education. This project aims to examine the regulatory challenges relating to post-secondary work experience, such as internships, in the areas of labour and employment, anti-discrimination and workers compensation law in Australia. The analysis is designed to establish a global and comparative context, examining policy and regulatory responses in Canada, Europe (including Britain), New Zealand, and the United States of America and at the international level. By offering a comprehensive analysis of the theoretical and practical implications of law's boundary between work and education, it is expected to identify optimum approaches to the regulation of post-secondary work experience, and thereby expand policy debates and enhance future law reform.Read moreRead less
Modelling cell invasion incorporating the epithelial to mesenchymal transition: Exploring therapies to control wound healing and cancer progression. Cancer and wounds are closely related, commonly lethal, diseases. Both require cell growth and invasion. This project will apply experimental measurements to create new mathematical models of cancer and wounds; models that will inform new targets and strategies for the treatment of these deadly diseases.
Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
Determining the sequence of events during eukaryotic translation initiation. Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is c ....Determining the sequence of events during eukaryotic translation initiation. Multiple benefits will arise from a more complete understanding of translation initiation. It is a frequent target for mechanisms that control gene expression and its dys-regulation is associated with human disease. For example, this is evident in cancer biology, since altered translation is a frequent cause of tumorigenesis. Translation is of universal importance for cellular function and knowledge of how it works is central to modern life sciences and its application to medical and biotechnological problems. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
Reactive oxygen species generation by zerovalent silver nanoparticles; implications to toxicity and contaminant degradation. Nanoparticulate silver is now being used for the purification of drinking water yet many questions remain concerning its mode of purifying action. Here we investigate the generation of reactive oxygen species (ROS) by nanoparticulate silver and examine the relationship between ROS generation and the purifying action of "nano-silver".
Measuring the impact of urban regulation on housing affordability in Australian cities and regions. Urban planning must ensure that development meets new environmental goals, but stringent regulation may reduce housing supply and affordability. This project uses new local planning data and econometric studies to quantify and monitor planning regulation impacts on housing supply and affordability in Australian cities and regions.
Broad spectrum nanomedicine for Meningitis treatment. Brain inflammatory diseases are among the top ten infectious causes of death. The project aims to provide Australian doctors with a superior alternative of treating infections that do not respond to conventional antibiotics. The nanomedicine developed will reduce the burden of hospital and boost Australia economy in the biomedical sector.
Pathogen sensing in systemic inflammatory disease. The initiation, amplification and quenching of an immune response is a carefully orchestrated process that eliminates invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that restrict immune responses to prevent inflammatory diseases such as rheumatoid arthritis, psoriasis and inflammatory bowel disease. This work will also explore the role of a potassium channel that protects the host from or ....Pathogen sensing in systemic inflammatory disease. The initiation, amplification and quenching of an immune response is a carefully orchestrated process that eliminates invading pathogens while minimising collateral damage to host tissues. This research focuses on proteins that restrict immune responses to prevent inflammatory diseases such as rheumatoid arthritis, psoriasis and inflammatory bowel disease. This work will also explore the role of a potassium channel that protects the host from organ failure during an infection, by coupling the energy requirements of mounting an immune response, and organ function. This may have important implications for the management of sepsis, a systemic immune response associated with infection and the leading cause of death in critically ill patients.Read moreRead less
Shadow care infrastructures: sustaining life in the post-welfare city. Mounting evidence points to difficulties faced by Australians reliant on government income support in meeting market costs of essential needs. This project investigates whether and how ‘shadow care infrastructures’ – a wide range of formal and informal material and social supports – enable the survival, well-being and flourishing of income support recipients. Focusing on people with disabilities, unemployed and asylum seekers ....Shadow care infrastructures: sustaining life in the post-welfare city. Mounting evidence points to difficulties faced by Australians reliant on government income support in meeting market costs of essential needs. This project investigates whether and how ‘shadow care infrastructures’ – a wide range of formal and informal material and social supports – enable the survival, well-being and flourishing of income support recipients. Focusing on people with disabilities, unemployed and asylum seekers, the study evaluates the benefits and harms such infrastructures produce for those receiving and providing care, and the wider community. It examines risks and opportunities to scale up emerging care infrastructures identified as critical to making ends meet for income support recipients in contemporary cities.Read moreRead less