Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will ex ....Multiscale stochastic modelling of genetic regulatory mechanisms. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework for exploring and validating genetic regulatory models in general. This will be used on an exemplar application for understanding the induction process in lambda phage.Read moreRead less
A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will d ....A Grid based platform for multi-scaled biological simulation. Heart disease currently affects over 3.5 million Australians. In 2006 it claimed the lives of almost 46,000 Australians (34% of all deaths). We will develop enabling technology that underpins cardiac disease research, offering potential for new treatments and pharmaceutical therapies. Even a small improvement in this area can translate into significant national benefit. Further, the mathematical techniques and software tools we will develop, whilst focused on heart tissue, will have broader applicability, and may underpin advancements in other disciplines. Finally, we expect that the software solutions and infrastructure will have both commercial and strategic value in their own right.Read moreRead less
Cross-Entropy Methods in Complex Biological Systems. The Cross-Entropy method provides a powerful new way to find superior solutions to complicated optimisation problems in biology, ranging from better design and implementation of medical treatments to an increased understanding of complex ecosystems.
Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a com ....Improved Monte Carlo Methods for Estimation, Optimisation and Counting. The project will benefit the Australian society by building the theoretical and methodological foundations for the next generation of Monte Carlo techniques. The advancement of the knowledge in this area will provide important tools for solving complex estimation, optimisation and counting problems in engineering, statistics, computer science, mathematics and the physical and life sciences. As a result it will generate a competitive advantage for various sections of the Australian industry, including telecommunications, biotechnology and finance. The project will enable Australian researchers to continue to work at the forefront of this fast moving and exciting area of international research.Read moreRead less
Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will he ....Secure and Efficient Cryptographic Hashing. This project will enhance information security, which is absolutely crucial for rapidly growing e-commerce, e-government services and for national security (Priority 4 -Safeguarding Australia - Protection against Terrorism and Crime). The project will strengthen international collaboration by reciprocal exchange of researchers and postgraduate students leading to more attractive and productive research environment. At the same time, the project will help to maintain high research profile of Australian researchers, to increase the capacity for consultancy and contract work, and provide a cutting-edge information technology for the Australian telecommunications industry, business and government (Priority 3 - Frontier Technologies). Read moreRead less