Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
The role of neurohormones in the regulation of appetite and successful sea water transfer in farmed Atlantic salmon. Cultured Atlantic salmon spend the first part of their life in freshwater and then following a physiological adaption phase called smoltification, the fish (now termed smolts) are transferred to sea cages for growout. A proportion of smolts fail to thrive after transfer, show slow or no growth and usually die some months later. This project will investigate the role that the neuro ....The role of neurohormones in the regulation of appetite and successful sea water transfer in farmed Atlantic salmon. Cultured Atlantic salmon spend the first part of their life in freshwater and then following a physiological adaption phase called smoltification, the fish (now termed smolts) are transferred to sea cages for growout. A proportion of smolts fail to thrive after transfer, show slow or no growth and usually die some months later. This project will investigate the role that the neurohomones that control both appetite and physiological stress in fish have in stimulating the resumption of feeding after sea water transfer.The basic knowledge generated will be used directly in development of strategies for minimising smolt failure in Atlantic salmon aquaculture.Read moreRead less
The cellular basis of temperature impairment of reproductive function in Atlantic salmon. Elevated summer and autumn temperatures, either as a result of normal climate variation or global warming, inhibit reproduction in salmonid fishes by disrupting endocrine (hormonal processes). The mechanisms involved are unclear but are known to involve inhibition of ovarian estrogen and the assembly of egg-yolk proteins. This project will investigate the cellular basis of the inhibitory effect of high temp ....The cellular basis of temperature impairment of reproductive function in Atlantic salmon. Elevated summer and autumn temperatures, either as a result of normal climate variation or global warming, inhibit reproduction in salmonid fishes by disrupting endocrine (hormonal processes). The mechanisms involved are unclear but are known to involve inhibition of ovarian estrogen and the assembly of egg-yolk proteins. This project will investigate the cellular basis of the inhibitory effect of high temperature on reproduction, at the ovarian and hepatic levels. The understanding developed will be an essential component of amelioration strategies for managing the continued successful rearing of salmon and trout under warming environmental conditions.Read moreRead less
Artificial Intelligence, Robots, and Agriculture: Social and ethical issues. This project aims to investigate the social and ethical issues raised by the use of artificial intelligence and robotics in agriculture. By combining social science research methods and philosophical analysis, the project aims to generate new knowledge in bioethics and applied ethics. Expected outcomes of this project include an account of the social and ethical issues farmers, rural communities, and consumers anticipat ....Artificial Intelligence, Robots, and Agriculture: Social and ethical issues. This project aims to investigate the social and ethical issues raised by the use of artificial intelligence and robotics in agriculture. By combining social science research methods and philosophical analysis, the project aims to generate new knowledge in bioethics and applied ethics. Expected outcomes of this project include an account of the social and ethical issues farmers, rural communities, and consumers anticipate arising from these technologies, improved understanding of these issues, and an account of how these groups would like to see these issues addressed. This should help Australia benefit from the responsible use of artificial intelligence and robotics in agriculture.Read moreRead less
Vulnerability, autonomy and justice. Vulnerable people require assistance and care. But what are our responsibilities in relation to the vulnerable? And how can we provide assistance and care while avoiding stereotyping or paternalism? This research will advance ethical theory and be useful in solving practical problems in health research and policy.
Discovery Early Career Researcher Award - Grant ID: DE150101390
Funder
Australian Research Council
Funding Amount
$363,536.00
Summary
Invasive Synthetic Biomedical Brain Device: Ethical and Policy Implications. The use of novel, invasive, synthetic, biomedical brain technologies such as predictable brain devices, 3D printed biomaterials, additive-bio-fabricated materials, and drug delivery systems have raised unprecedented ethical issues for research. Given the therapeutic potential and high risk of harm associated with synthetic biomedical applications, it is critical to identify the ethical issues before these novel applicat ....Invasive Synthetic Biomedical Brain Device: Ethical and Policy Implications. The use of novel, invasive, synthetic, biomedical brain technologies such as predictable brain devices, 3D printed biomaterials, additive-bio-fabricated materials, and drug delivery systems have raised unprecedented ethical issues for research. Given the therapeutic potential and high risk of harm associated with synthetic biomedical applications, it is critical to identify the ethical issues before these novel applications are widely used in human clinical trials. This project aims to explore how research trial guidelines can address the ethical issues raised by these new brain applications.Read moreRead less
The drowned: cultural and political geographies. This project aims to reveal and critically analyse the geographies of drowning and the drowned. Drowning is the third most common cause of death worldwide, and a subject of universal interest that is relatively limited in specifically cultural and political geographical research, policy, and debate. The project will be significant by rectifying that gap and investigating shared concerns about drowning’s abiding, widespread, profound effects. The e ....The drowned: cultural and political geographies. This project aims to reveal and critically analyse the geographies of drowning and the drowned. Drowning is the third most common cause of death worldwide, and a subject of universal interest that is relatively limited in specifically cultural and political geographical research, policy, and debate. The project will be significant by rectifying that gap and investigating shared concerns about drowning’s abiding, widespread, profound effects. The expected outcomes will include public debate about drowning and its cultural and political reach and management generated from a book, articles, and blog. Benefits will include new fundamental knowledge and practical insights about how to rethink risks and disasters in rapidly changing environments.Read moreRead less
Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will ena ....Developing feasible in situ control of mange disease in wombats. Our goal is the development of feasible in situ control of sarcoptic mange in wombat populations. Globally important, the Sarcoptes scabiei mite infects >100 mammal species and is among the 50 most common human diseases, causing health, welfare and population impacts. This infection is treatable, and we will test a new treatment (fluralaner), develop new models to guide management, and conduct replicated field trials. This will enable science-based guidelines, advancing disease control, local eradication, and regulatory approval for wombats. Our research framework is adaptable to other mange-impacted species, and advance methods and theory for control of treatable disease in wildlife.Read moreRead less
Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to pred ....Eddy-resolving global ocean-sea ice modelling. Eddy-resolving global ocean-sea ice modelling. This project aims to develop a world-class global ocean-sea ice model framework through a nationwide consortium. The resulting high resolution models are expected to provide the foundation for the next decade of Australian ocean-sea ice modelling capacity. This research should lead to improved ocean and sea ice prediction, ocean reanalyses, and climate projections, enhancing Australia's capacity to predict the ocean state on timescales of days to decades. This is expected to yield efficiencies in shipping, marine search and rescue and naval operations, and increase the accuracy of projected future changes in climate, sea level, ocean ecosystems and the cryosphere.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100937
Funder
Australian Research Council
Funding Amount
$373,484.00
Summary
Turbulent mixing in the deep Southern Ocean. Mixing in the Southern Ocean strongly affects the transport and storage of heat, carbon, and nutrients in the global ocean and hence climate itself. Yet processes generating mixing in the Southern Ocean remain poorly understood and inadequately represented in present ocean and climate models. This project aims to: understand mixing processes based on an innovative approach combining sparse observations and computer simulations; and to implement this u ....Turbulent mixing in the deep Southern Ocean. Mixing in the Southern Ocean strongly affects the transport and storage of heat, carbon, and nutrients in the global ocean and hence climate itself. Yet processes generating mixing in the Southern Ocean remain poorly understood and inadequately represented in present ocean and climate models. This project aims to: understand mixing processes based on an innovative approach combining sparse observations and computer simulations; and to implement this understanding into a state-of-the-art climate model to study mixing impacts on the ocean circulation and climate. This project aims to produce substantial improvements in climate models and allow Australia to predict and respond more effectively to climate change.Read moreRead less