Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capab ....Enhanced multivalent vaccine responses using a novel vaccine vector system. Enhanced multivalent vaccine responses using a novel vaccine vector system. This project aims to develop a multicomponent vaccine system to deliver equal effectiveness against several disease targets in a single administration. New and innovative vaccine design strategies incorporating economical commercial production processes are urgently needed for new and existing human and animal health applications. A vaccine capable of targeting multiple diseases by a single injection is an obvious way to expedite future vaccine development and deployment. However, the recipient’s immune system can repress equivalent responses to these multicomponent vaccines. This project’s research is expected to address these problems, and underpin the future commercial development of this vaccine platform.Read moreRead less
Mab Immunotherapies For Myeloid Leukemia Patients With Germline Or Somatic RUNX1 Mutations.
Funder
National Health and Medical Research Council
Funding Amount
$766,995.00
Summary
This proposal presents preliminary evidence and proposes to confirm that 2 cell surface molecules, CD11a (ITGAL) and IL3RA (CD123) are direct (probably repression) targets of RUNX1 in HSCs, and are dysregulated in RUNX1 mutated AML. Monoclonal antibody therapies that target these two surface molecules have already passed different clinical trial phases for different diseases. We plan to show these antibodies are effective in RUNX1 positive AML in preclinical models and then clinical trials.
The development of a potent new passive immunotherapeutic for the treatment and prevention of bacterial sepsis and septic shock. Bacterial sepsis and septic shock is a leading cause of death in hospital intensive care units and represents a significant public health burden. By developing a new passive immunotherapeutic regimen to treat and prevent bacterial sepsis and septic shock, the project aims to reverse the significant mortality and morbidity associated with this condition.
Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of ....Exploring the immunomodulatory potential of Natural Killer T cells. Natural Killer T cells (NKT cells) are an innate-like population of T cells that recognise a range of lipid based antigens when bound to the antigen-presenting molecule, CD1d. Once activated, NKT cells rapidly secrete a variety of cytokines. This project, in partnership with Vaxine Pty Ltd, aims to gain a basic understanding of NKT recognition of lipids and NKT cell activation by lipids. The project aims to use a combination of cellular immunology and structural biology to gain insight into NKT cell agonism.Read moreRead less
Development of sophisticated structural design guidelines for the new building product known as Rapidwall. Rapidwall is an Australian made new composite building product made from formulated gypsum plaster and glass-fibre. This is a high-tech building product that has huge potential to be developed into a dominant building material in the future. It is economic, labor effective, eco-friendly, structural sound and fire, thermal resistant and has many advantages over the existing building material ....Development of sophisticated structural design guidelines for the new building product known as Rapidwall. Rapidwall is an Australian made new composite building product made from formulated gypsum plaster and glass-fibre. This is a high-tech building product that has huge potential to be developed into a dominant building material in the future. It is economic, labor effective, eco-friendly, structural sound and fire, thermal resistant and has many advantages over the existing building materials, such as concrete, steel and masonry. The lack of a technical design guidelines has fundamentally obstructed it from expanding its market share both in Australia and overseas. This proposal aims at developing a structural design manual for the new product.Read moreRead less
A New Generic Approach for Assessing Blast Effects on Reinforced Concrete Members. A framework allow for both flexural and shear response analysis using a new segmental approach is developed in this proposal. A blast test program is designed to validate the framework for reinforced concrete members. The validated framework is then used to derive normalised pressure impulse programs for reinforced members in unconfined and confined spaces. This project will provide design engineers guidelines for ....A New Generic Approach for Assessing Blast Effects on Reinforced Concrete Members. A framework allow for both flexural and shear response analysis using a new segmental approach is developed in this proposal. A blast test program is designed to validate the framework for reinforced concrete members. The validated framework is then used to derive normalised pressure impulse programs for reinforced members in unconfined and confined spaces. This project will provide design engineers guidelines for reliably and quickly assessing the effect of different kinds of blast loads on different types and properties and geometries of reinforced concrete structural members, saving computation time and efforts while providing increased realism and accuracy.Read moreRead less
Experimental investigation and constitutive modelling of reactive soils. This project aims to develop the fundamental knowledge, a mechanical framework and practical engineering design tools needed to minimise the effects of reactive soils on infrastructure. Reactive soils undergo significant swelling and weakening upon wetting or intrusion by salt-rich groundwater and shrinkage upon drying. This can result in damage to buildings and infrastructure beyond a state of repair. This project will dev ....Experimental investigation and constitutive modelling of reactive soils. This project aims to develop the fundamental knowledge, a mechanical framework and practical engineering design tools needed to minimise the effects of reactive soils on infrastructure. Reactive soils undergo significant swelling and weakening upon wetting or intrusion by salt-rich groundwater and shrinkage upon drying. This can result in damage to buildings and infrastructure beyond a state of repair. This project will develop tools, models and theories to detect weaknesses in the design of infrastructure and its foundations built on problematic reactive soils, assess the impact and implement effective remedial measures to improve performance. The project is expected to increase efficiency through improved design and reduced damage, and save infrastructure owners, government and private, tens of millions of dollars each year.Read moreRead less
Combining transient micro-reflections and multi-sensor arrays for condition assessment of buried pipes. This project will develop an accurate and reliable approach for assessing the condition of pipelines. This new approach will reduce costs and save considerable amounts of water each year, as it will assist utilities in preventing major failures such as pipe bursts, and performing strategically targeted maintenance, replacement and rehabilitation.
Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city enviro ....Detecting developing cracks before pipe bursts using smart sensor systems. This project aims to significantly reduce the number of pipe bursts in cities by detecting the leaks from developing cracks on water supply pipes just in time. New techniques will be developed for reliable and timely detection using the existing sensor network in the Adelaide CBD. Specialised monitoring stations will be developed with adaptive noise-cancellation algorithms to detect small leak signals in noisy city environments. Expected outcomes include an effective pipe burst early warning system and the implementation of an active burst prevention and targeted pipe replacement strategy. This should significantly reduce the burst rates and associated interruptions in Adelaide and save millions of dollars every year in pipe relay programs.Read moreRead less
Cost Effective Pipeline Condition Assessment Using Paired Pressure Sensor Arrays. Water distribution networks represent society's most important infrastructure asset. They are buried pipes and are often old and deteriorating. Cost-effective methods to assess their physical condition are urgently needed. This research will develop a novel and advanced approach to determine the interior condition of pipes quickly and effectively using small water hammer pulses or waves. Paired pressure sensor arra ....Cost Effective Pipeline Condition Assessment Using Paired Pressure Sensor Arrays. Water distribution networks represent society's most important infrastructure asset. They are buried pipes and are often old and deteriorating. Cost-effective methods to assess their physical condition are urgently needed. This research will develop a novel and advanced approach to determine the interior condition of pipes quickly and effectively using small water hammer pulses or waves. Paired pressure sensor arrays will be used to measure reflections of the waves in pipes and these methods will enable finer resolution and identification of pipeline faults, such as wall thickness loss and leakage while at the same time allowing operational continuity. The outcome will be powerful tools to more cost effectively manage these crucial assets.Read moreRead less