Antibody-Dependent Cellular Cytotoxicity Based Immunity To Influenza
Funder
National Health and Medical Research Council
Funding Amount
$677,938.00
Summary
Pandemic influenza causes widespread disease, death and panic. Producing vaccines to new strains takes time. There is a need to produce vaccines that provide partial protection against unknown strains. We identified a type of anti-influenza antibody in people with prior influenza infection that may assist in reducing disease from new influenza strains. We will study these antibodies, understanding how effective they against influenza, with a view to making improved anti-influenza vaccines.
A Novel Role For MHC Class II In Carbohydrate Presentation
Funder
National Health and Medical Research Council
Funding Amount
$703,030.00
Summary
Cells of the immune system swallow up foreign molecules and break them down to smaller fragments. T cells then identify the degraded antigen fragments and coordinate the immune response. In this project we will investigate how the T cells identify carbohydrates.
The Roles Of The Transcriptional Regulators Id2 And Id3 In Plasma Cell Differentiation And B Cell Memory
Funder
National Health and Medical Research Council
Funding Amount
$438,951.00
Summary
Antibody producing cells and memory B cells are crucial to successful vaccination and provide protection against infections. Development of both is controlled by factors that regulate gene activity, but the same factors are also involved in the development of blood cancers. Using new research tools and assays we will uncover the roles of the Id and E protein family of factors implicated in these processes, which may help in the design of new vaccination strategies and the treatment of blood canc ....Antibody producing cells and memory B cells are crucial to successful vaccination and provide protection against infections. Development of both is controlled by factors that regulate gene activity, but the same factors are also involved in the development of blood cancers. Using new research tools and assays we will uncover the roles of the Id and E protein family of factors implicated in these processes, which may help in the design of new vaccination strategies and the treatment of blood cancers.Read moreRead less
The Mechanism And Application Of A Superagonistic Antibody For Human IL-21.
Funder
National Health and Medical Research Council
Funding Amount
$95,313.00
Summary
Monoclonal antibodies are widely used in diagnosis and therapy due to their outstanding specificity and safety. The monoclonal antibodies recognizing cytokines with enhancing functions are an emerging class of novel reagents in immunotherapy. This project is to investigate how a newly indentified monoclonal antibody enhances the activity of a cytokine and use this immunostimulatory function to design new strategies for better vaccination and treatment for cancer and infection.
PH-dependent, Antibody-mediated Enhancement Of Genital Chlamydial Infection: Implications For Vaccine Design ?
Funder
National Health and Medical Research Council
Funding Amount
$373,228.00
Summary
Antibody found in cervicovaginal secretions is predominantly of the IgG subclass. In the acidic environment of the female reproductive tract IgG antibodies against surface antigens on Chlamydia may actually enhance rather than prevent infection, due to uptake of IgG-coated bacteria by the neonatal Fc receptor (FcRn), which is found on the surface of epithelial cells in the reproductive tract. The proposed studies will determine the effects of chlamydial antibodies on the course of infection.
Cytokine Structure And Mechanisms Of A Superagonist Antibody
Funder
National Health and Medical Research Council
Funding Amount
$349,590.00
Summary
Monoclonal antibodies are widely used in diagnosis and therapy due to their outstanding specificity and safety. The monoclonal antibodies recognizing cytokines with enhancing functions are an emerging class of novel reagents in immunotherapy. This project is to investigate how a newly indentified monoclonal antibody enhances the activity of a cytokine and use this immunostimulatory function to design new strategies for better vaccination and treatment for cancer and infection.
The role of non-coding RNAs in T cell development. The goal of this project is to discover the genes responsible for the development of a healthy immune system. To achieve this goal, a battery of next generation genomics technologies are being applied for the discovery of new genes and to study their function.