Unraveling Mechanisms Of Liver Transplant Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$694,822.00
Summary
Liver transplants are unique amongst solid organs as they are spontaneously accepted across different individuals and induce acceptance of other organs from the same donor co-transplanted at the same time. Using a new mouse liver transplantation model, this proposal will elucidate how the liver tissue performs this function and identify new markers associated with tolerance in the blood of mice. This knowledge will be used to identify liver transplant patients with reduced rejection risk.
Deciphering Mechanisms Of Liver Allograft Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$520,964.00
Summary
The liver has paradoxical properties: it is the site of effective immune responses to pathogens, but under some circumstances, it is known to induce harmless immune responses. Liver transplants are more readily accepted than other organ grafts in the absence of immunosuppressive drugs but little is known about the mechanisms that prevent an effective response. This proposal aims to unravel these mechanisms. This project will have important implications for transplantation studies.
Deciphering How TCR Affinity Regulates CD4 T Cell Help In Immunity And Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$850,885.00
Summary
Immune responses require the coordinated interaction and cross-talk between two types of white blood cells known as CD4 and CD8 T cells. A dysregulated interaction between these cells could be the cause of autoimmune and persistent infections by pathogens leading to chronic diseases. The aim of this proposal is to provide a deeper understanding of CD4/CD8 T cell interactions to improve immune outcomes in many chronic diseases in which interaction between these two immune cells is critical.
A Unique Network Of Phagocytic Cells At The Interface Between The Liver And Peritoneal Cavity
Funder
National Health and Medical Research Council
Funding Amount
$787,521.00
Summary
This project aims to characterise the nature and ontogeny of a novel population of cells with phagocytic capacity that forms a network underlying the capsule of mouse and human liver reminiscent of that formed by Langherans cells in the epidermis of the skin. In this project we will characterise this newly described liver capsular macrophage subset, define their ontogeny and assess their specific functions.
Inflammatory Mediators Of Liver Injury In Chronic Hepatitis C
Funder
National Health and Medical Research Council
Funding Amount
$349,336.00
Summary
Presently, liver disease from chronic hepatitis C and obesity represents a major health problem. Overall, approximately 50% of Australians with chronic hepatitis C are obese and these patients are at significantly increased risk of rapidly progressing to liver failure. It is now recognized that fat derived factors play an important role in regulating inflammatory responses. This grant proposal aims to gain insight into how liver and fat derived inflammatory factors interact to promote increased ....Presently, liver disease from chronic hepatitis C and obesity represents a major health problem. Overall, approximately 50% of Australians with chronic hepatitis C are obese and these patients are at significantly increased risk of rapidly progressing to liver failure. It is now recognized that fat derived factors play an important role in regulating inflammatory responses. This grant proposal aims to gain insight into how liver and fat derived inflammatory factors interact to promote increased liver damage in chronic hepatitis C and obesity.Read moreRead less
Protecting Against Malaria Through Liver-resident Memory T Cells
Funder
National Health and Medical Research Council
Funding Amount
$1,196,853.00
Summary
We have shown that formation of liver-resident memory T cells (Trm), a newly discovered type of immune cells, can be induced by an innovative vaccination strategy called prime and trap for highly efficient protection against malaria in mice. Here, we will enhance prime and trap vaccination efficacy by defining the conditions that maximize liver Trm-mediated protection and will characterize simian and human liver Trm cells, paving the way to create the most efficient human malaria vaccine to date
Optimizing steel industry supply chains through constraint and market-oriented programming. Supply chain optimization is a difficult problem, but of considerable significance to business enterprises. Constraint programming technology is a promising approach to solving such problems, but is inadequate in the context of dynamic supply chains. Market-oriented programming solves resource allocation problems by setting up artificial computational economies of trading software agents and holds promise ....Optimizing steel industry supply chains through constraint and market-oriented programming. Supply chain optimization is a difficult problem, but of considerable significance to business enterprises. Constraint programming technology is a promising approach to solving such problems, but is inadequate in the context of dynamic supply chains. Market-oriented programming solves resource allocation problems by setting up artificial computational economies of trading software agents and holds promise both as an optimization tool and as a tool that supports explicit market negotiation. This project seeks to address several open questions relating to the integrated deployment of these two classes of techniques, in the context of building a practical supply chain optimization system for BHP Steel.Read moreRead less
Managing quality of experience delivery in new generation telecommunications networks with e-negotiation. New generation telecommunications networks are required to support increasingly demanding services, including interactive multimedia and conferencing. The success of these networks will rely on the users' perception of their quality of experience. The management of these networks will rely on the ability of informed decision making that competes effectively for limited resources in such a ....Managing quality of experience delivery in new generation telecommunications networks with e-negotiation. New generation telecommunications networks are required to support increasingly demanding services, including interactive multimedia and conferencing. The success of these networks will rely on the users' perception of their quality of experience. The management of these networks will rely on the ability of informed decision making that competes effectively for limited resources in such a highly dynamic environment. This project will design information distribution strategies and smart decision making agents that negotiate a user's quality of experience using market mechanisms. Designs from this project will be trialled and validated in the partner's commercial networks.Read moreRead less
Smart communications network management: Delivering bundled interdependent services across internetworked heterogeneous domains. Sophisticated communications network management (data, voice, video) is crucial to the global economy. The field is worth several billion dollars per annum. This project will generate expertise that addresses and solves an important problem in communications management, will enable Australia to use communications networks more effectively, and will advance communicatio ....Smart communications network management: Delivering bundled interdependent services across internetworked heterogeneous domains. Sophisticated communications network management (data, voice, video) is crucial to the global economy. The field is worth several billion dollars per annum. This project will generate expertise that addresses and solves an important problem in communications management, will enable Australia to use communications networks more effectively, and will advance communications technology. Read moreRead less