Early Career Industry Fellowships - Grant ID: IE230100042
Funder
Australian Research Council
Funding Amount
$462,846.00
Summary
Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules a ....Developing a multimodal imaging pipeline for antisense technology. Antisense molecules represent a revolutionary drug discovery platform for life science, but to understand their distributions in cells and tissues is challenging. By integrating nanobiotechnology approaches, this project expects to develop and apply innovative imaging workflow to track antisense molecules in cells and tissues with nanoscale precision. Expected outcomes include new knowledge of the trafficking of these molecules across cells and tissues and refined imaging methods. This project should provide more strategic delivery of antisense molecules to specific cells and tissue, which will have significant downstream economic and social benefits to the Australian community. Read moreRead less
Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This p ....Tools for manipulating neuronal activity for behavioural studies. This project aims to develop optogenetic tools neuroscientists can use to better understand brain circuitry and the functional effects of specific neurons on behaviour. Linking the activity of individual neurons in the brain to specific behaviours is a major challenge in neuroscience. Optogenetics achieve this by using light to control the activity of neurons. This has advanced understanding of behaviour and neurocircuitry. This project is expected to increase understanding of brain function at the cellular and system levels, and advance Australia’s multidisciplinary research capacity in neuroscience, cognitive sciences and nanobiotechnology to ultimately treat neurological disorders.Read moreRead less