UNDERSTANDING THE BENEFITS AND LIMITATIONS OF METAPHASE II SPINDLE TRANSFER
Funder
National Health and Medical Research Council
Funding Amount
$1,629,373.00
Summary
Mitochondrial DNA (mtDNA) diseases are transmitted from a mother's eggs to her children. However, the levels of affected mtDNA differ amongst her eggs. Consequently, a carrier would not know if the newborn child were to suffer from these diseases. Mitochondrial Donation offers couples the potential to have an unaffected child. We will undertake the most comprehensive study of mitochondrial donation using one of its associated approaches to determine if it produces healthy embryos and offspring.
Improving Oocyte Mitochondrial DNA Copy Number To Enhance Female Reproductive Capacity.
Funder
National Health and Medical Research Council
Funding Amount
$670,867.00
Summary
Eggs with too few copies of mitochondrial DNA either fail to fertilise or arrest during early development. By supplementing eggs with mitochondrial DNA, we have been able to enhance embryo quality and gene expression profiles. By breeding the offspring derived from eggs given mitochondrial supplementation, we will determine if they and their progeny meet normal developmental milestones, regulate the transmission of mitochondrial DNA appropriately, and are healthy and fertile.
Infertility is common and although IVF is widely accepted, the procedure is expensive and is associated with health risks. Using laboratory animals, we have made significant advances towards developing new technologies that can mature eggs and produce embryos in vitro, but without women receiving hormone injections. This project will seek means to combine the benefits of two of our existing technologies into one integrated system, to provide hormone-free infertility treatment.
Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to matu ....Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.Read moreRead less
Dissecting the impact of stress on reproduction: Novel peptide mediates inhibitory effects of stress on female reproduction. This research proposal offers a pioneering opportunity to develop treatments that overcome the negative impact of stress on reproduction. Specifically, knowledge generated in this project will be vital in the development of strategic defences against the impact of stress on reproduction. This project fundamentally addresses Research Priority 2: Promoting and maintaining go ....Dissecting the impact of stress on reproduction: Novel peptide mediates inhibitory effects of stress on female reproduction. This research proposal offers a pioneering opportunity to develop treatments that overcome the negative impact of stress on reproduction. Specifically, knowledge generated in this project will be vital in the development of strategic defences against the impact of stress on reproduction. This project fundamentally addresses Research Priority 2: Promoting and maintaining good health. Given that suppression of reproduction by stress occurs in all mammalian species including humans, domestic animals and wildlife, being able to prevent or overcome stress-induced reproductive dysfunction will generate significant health, social, economic and ecological benefits. Read moreRead less
Male-female Sperm Signalling - A Novel Pathway For Peri-conceptual Health?
Funder
National Health and Medical Research Council
Funding Amount
$674,920.00
Summary
This project will investigate a new biological process in reproduction, whereby sperm delivered to the cervix at coitus transmit signalling molecules called microRNAs that influence the female immune response, to increase the chances of conception and pregnancy. We will define the molecular details of this signalling pathway in mouse models, and then determine whether human sperm have a comparable function in ‘priming’ the female body to conceive.
Running Hot: Increasing the Availability of World-Class Precision Timing . Precision clocks are a key enabler for many important technologies including navigation, radar, distributed computing and communications. Unfortunately, the very best clocks are currently bulky and very expensive. This project will take Australia’s multi-award winning sapphire clock technology and transform it so that its unmatched performance is available from a unit with an order of magnitude smaller size, power consum ....Running Hot: Increasing the Availability of World-Class Precision Timing . Precision clocks are a key enabler for many important technologies including navigation, radar, distributed computing and communications. Unfortunately, the very best clocks are currently bulky and very expensive. This project will take Australia’s multi-award winning sapphire clock technology and transform it so that its unmatched performance is available from a unit with an order of magnitude smaller size, power consumption and cost. This transformation will be driven on the back of a patented revolutionary step that allows operation of the sapphire clock at higher cryogenic temperatures. The new clock will have a wider range of applications delivering more computational power, higher bandwidth transmissions and better radar. Read moreRead less
Network Management in a World of Secrets. The aim of this proposal is to provide world leading measurement and management techniques for the Internet and other telecommunications networks. In particular, the methods will improve privacy of network participants (customers and providers) while simultaneously improving network performance. Additionally, the project will create expertise in an area of great future interest -- privacy preserving computation -- expertise that can be transferred to stu ....Network Management in a World of Secrets. The aim of this proposal is to provide world leading measurement and management techniques for the Internet and other telecommunications networks. In particular, the methods will improve privacy of network participants (customers and providers) while simultaneously improving network performance. Additionally, the project will create expertise in an area of great future interest -- privacy preserving computation -- expertise that can be transferred to students and the next generation of innovators.
Apart from these benefits, the research will provide exposure of Australian research strength in an area of world-wide public interest. Results concerning Internet reliability are of particularly high impact. Read moreRead less
Interactions between cells and extracellular matrix in the epithelial-mesenchymal transition of the ovarian follicular stratified epithelium. The lining of many mammalian organs and cavities contain cells that can transform into different cells to bring about organ development or repair but if it goes horribly wrong the cells become metastatic cancers. This project examines the key features of this process especially the roles of matrix that develops around the cells in this process.
Telematics: Research & Development of Mobile Link for Telemedicine. This project is aimed at producing a reliable mobile video link between ambulance and hospital. In an emergency situation, video footage greatly assists the medical team in accurate deployment of resources to save lives. Motorola will be the industrial partner and this mobile telemedicine project fits into their telematics core business area. Together with Motorola, we will investigate video coding schemes, protocols and network ....Telematics: Research & Development of Mobile Link for Telemedicine. This project is aimed at producing a reliable mobile video link between ambulance and hospital. In an emergency situation, video footage greatly assists the medical team in accurate deployment of resources to save lives. Motorola will be the industrial partner and this mobile telemedicine project fits into their telematics core business area. Together with Motorola, we will investigate video coding schemes, protocols and network issues, to produce a commercially viable software/hardware solution. The outcome will be a working testbed that can be trialed at the Royal Adelaide Hospital. The IP generated will benefit Motorola's telematics directive and training will generate a potentially useful future employee.Read moreRead less