Understanding The Genetic Basis Of Breast Cancer: Translation To Primary And Secondary Prevention
Funder
National Health and Medical Research Council
Funding Amount
$2,731,372.00
Summary
We have identified >200 regions of the genome that contain variants that increase breast cancer risk. I will now focus on the main challenges i.e. to a) find the remaining genetic risk factors that will collectively explain all of the genetic risk, b) understand how these work, in particular which genes they influence and c) apply this knowledge to find and develop new drugs. Importantly, such drugs could be used not only to treat breast cancer, but also to prevent it in high-risk women.
Improved Early Respiratory Support Of Infants And Children
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Worldwide respiratory disease in children has the highest health care burden on society. Children aged <5 years in particular, are increasing in hospital admissions and to intensive care where the cost is elevated. New ways of oxygen therapy have been studied and shown that we can reduce ICU admission if a therapy known as Nasal High Flow (NHF) therapy is applied earlier in the progression of the disease. Further research is needed in NHF therapy and to improve upon our patient outcomes.
Early Life Exposures And Chronic Disease: Mechanisms And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$2,714,215.00
Summary
The world is in the grips of an epidemic of chronic disease and exposure to pollution in early life is partly responsible. To change this situation we need to understand and mitigate the mechanisms linking early life pollution exposure to life-long disease risk. My research will provide direct evidence of how pollution increases disease risk and design and implement strategies to reduce this, with an emphasis on asthma, cystic fibrosis and chronic respiratory disease.