This project will take robust evidence regarding inflammation based management, comorbidity and self management and translate it into practice using a national implementation framework.
Airway Inflammometry For Asthma And COPD: Practitioner Fellowship Peter G Gibson
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Asthma and chronic obstructive pulmonary disease will receive the benefits of personalized medicine with this Fellowship funding. Dr Gibson, an international leader in this field, has identified key biomarkers that will allow treatments to be rationalized based on the underlying disease mechanisms. This research will translate the benefits on modern technology and apply these to individualized care for people with asthma and COPD, who can expect fewer lung attacks and better quality of life.
Localised Airway Reactivity As A Determinant Of Asthma Control And AHR
Funder
National Health and Medical Research Council
Funding Amount
$306,562.00
Summary
Asthma morbidity and mortality remain high, with drug cost, days lost from school and work. This may be due to severe asthma in which control cannot be attained. This may be due to localised regions of lung that remain persistently responsive to inhaled irritants. We will examine the location and size of these regions using 3-dimensional ventilation scanning. The potential importance of our findings is in providing a basis for improving treatment in resistant, severe asthma.
Centre Of Research Excellence In Asthma Treatable Traits (CREATT)
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
This CRE will focus on personalised medicine in asthma, specifically using the treatable traits approach. We have identified disease management areas of highest importance to people with asthma and health care providers. We will generate new knowledge, develop and strengthen collaborations and train translation focused researchers to develop high quality evidence and translate this to practice.
National Clinical Centre Of Research Excellence In Severe Asthma
Funder
National Health and Medical Research Council
Funding Amount
$2,597,952.00
Summary
Severe Asthma remains a large burden for the Australian community. It does not respond to current management approaches. We will develop and implement a targetted therapy approach to severe asthma that will involve assessment of needs of people with severe asthma, community burden form severe asthma, biomarkers and linked treatment strategies, as well as knowledge transfer tools and training of the health and medical workforce.
Optimising Asthma Management In Pregnancy For Optimal Infant Health
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Asthma affects 12% of pregnant women in Australia. These women are at increased risk of poor pregnancy outcomes, such as preterm birth and hospitalisation of the neonate. Reducing asthma attacks by providing optimal asthma management during pregnancy may lower these risks. This research will test whether a strategy which determines treatment changes based on a marker of airway inflammation, improves outcomes for maternal, neonatal and child health.
The Effect Of Asthma Control During Pregnancy On Markers Of Airways Inflammation And Lung Function In The Offspring
Funder
National Health and Medical Research Council
Funding Amount
$1,131,043.00
Summary
Asthma is the most common chronic disease complication during pregnancy. By improving asthma management we have reduced asthma exacerbations by 50% during pregnancy and their babies suffered less often from bronchiolitis in the first year of life, which can be a life threatening infection. As bronchiolitis also promotes the development of asthma we want to investigate whether better asthma management in pregnancy leads to less lung inflammation and better lung function in the children.
Asthma Management In Pregnancy: Evaluating Costs, Benefits And Behaviours
Funder
National Health and Medical Research Council
Funding Amount
$319,157.00
Summary
Asthma is the most common complication to affect pregnancy and it worsens with pregnancy contributing to an increased incidence of morbidity and mortality for the baby. We think we can improve the health of the pregnant, asthmatic mothers and prevent a poor outcome for the baby by empowering asthmatic mothers to self manage their disease through education in an antenatal setting. We will assess whether antenatal asthma education and management is a cost effective approach to managing this diseas ....Asthma is the most common complication to affect pregnancy and it worsens with pregnancy contributing to an increased incidence of morbidity and mortality for the baby. We think we can improve the health of the pregnant, asthmatic mothers and prevent a poor outcome for the baby by empowering asthmatic mothers to self manage their disease through education in an antenatal setting. We will assess whether antenatal asthma education and management is a cost effective approach to managing this disease during pregnancy.Read moreRead less
The Breathing For Life Trial (BLT): A Randomised Trial Of Fractional Exhaled Nitric Oxide Based Management Of Asthma During Pregnancy And Its Impact On Perinatal Outcomes And Infant And Childhood Respiratory Health
Funder
National Health and Medical Research Council
Funding Amount
$1,722,020.00
Summary
Asthma affects 12% of pregnant women in Australia. These women are at increased risk of poor pregnancy outcomes, such as preterm birth and hospitalisation of the neonate. Reducing asthma attacks by providing optimal asthma management during pregnancy may lower these risks. We will test whether a strategy which determines treatment changes based on a marker of airway inflammation, improves outcomes for maternal, neonatal and child health.
Mechanisms Of Impaired Bronchodilator Response Associated With Fatty Acid Intake In Obese Asthma
Funder
National Health and Medical Research Council
Funding Amount
$694,365.00
Summary
Obese asthmatics typically have a high dietary fat intake, which reduces the efficacy of their asthma medications. We will determine which types of dietary fat affect asthma medications. We will also determine which asthma medications are affected by a high fat load. Finally, we will examine the mechanisms by which fatty acids affect the efficacy of asthma medications. This is will inform new treatment options for managing the many obese asthmatics who are not able to achieve weight loss.