How Intestinal Motility Activates Sensory Pathways
Funder
National Health and Medical Research Council
Funding Amount
$555,875.00
Summary
Pain and discomfort from the gut are common and unpleasant. We understand how gut sensory nerve cells work, at the cellular, molecular and genetic level. However, movement of the gut wall and contents are the major cause of activation of sensory neurons. We know little about which particular patterns of movement cause pain. This is crucial information for accurately diagnosing human gut disorders, for monitoring effectiveness of treatments and for identifying potential new drug targets.
How The Lateral Habenula Integrates Behavioral And Autonomic Functions: The VTA Dopamine Connection
Funder
National Health and Medical Research Council
Funding Amount
$819,904.00
Summary
When adverse events occur, the lateral habenula, an old brain nucleus, helps calculate the wisest corrective action by contributing to the “brake” that controls the brain’s dopamine reward system. Our research will show how the lateral habenula links corrective changes in behavior with coordinated changes in temperature. Understanding this link will greatly contribute to understanding the brain mechanisms that regulate our physiology during stressful situations and as part of mental illness.
Improving Pain And Movement Outcomes In Symptomatic Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
People fear getting painful knee osteoarthritis (OA) more than any other disease – it is seen as progressive and incurable. It often stops people from moving and staying healthy, resulting in an enormous burden on sufferers and the health care system. This program of research aims to understand what brain & nervous system processes might underlie these pain and movement problems and whether new brain-targeting treatment helps. This will allow us to better match treatment to what patients need.
There’s recent evidence that children get leaner and fitter during the school term, but become fatter and less fit over the summer holidays. This may be because of differences in activity and diet: on holidays, children may eat more, be less active and have more screen time. We propose to track the time use, diet, fitness and fatness of 9-11 year old children across three school years. If the pattern is confirmed, we should focus more on the home environment, or perhaps encourage summer camps.
Using Online Social Technologies To Improve Health Behaviour
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Physical inactivity and poor eating habits are leading causes of death and disease in Australia. Our health behaviours are influenced by our social networks. What’s more, Australians love social technologies, such as Facebook and smartphones. My research aims to harness these two factors to create socially-influential health programs. I will work with video game developers to develop fun and engaging interventions, and a viral marketer and leading organisations to spread the interventions.
Mapping sites of visceral convergence connecting the colon and bladder. This project aims to develop multiple neuroanatomical approaches to identify where in the central nervous system the sensory signalling from the colon and bladder merge. The combination of such technologies is novel to the study of the central circuits relaying colon/bladder convergence into the brain and will generate new and detailed knowledge of the central pathways in which pelvic organ sensory (discomfort) and motor (de ....Mapping sites of visceral convergence connecting the colon and bladder. This project aims to develop multiple neuroanatomical approaches to identify where in the central nervous system the sensory signalling from the colon and bladder merge. The combination of such technologies is novel to the study of the central circuits relaying colon/bladder convergence into the brain and will generate new and detailed knowledge of the central pathways in which pelvic organ sensory (discomfort) and motor (defecation/urination) functions are coordinated. The expected outcomes are predicted to aid future discovery of mechanisms of cross-organ sensitisation and are anticipated to provide significant benefit to therapy development for chronic visceral pain syndromes associated with bowel and bladder dysfunction.Read moreRead less
Active Team – Examining An Online Social Networking Intervention To Increase Physical Activity In Controlled (RCT) And Ecological (ET) Settings
Funder
National Health and Medical Research Council
Funding Amount
$814,041.00
Summary
Lifestyle diseases, such as heart disease and diabetes, are key health problems facing Australia. Effective, low-cost, mass-reach physical activity interventions are urgently needed. This project uses online social networks to deliver an innovative physical activity intervention. This project will determine how effective the software is in changing people’s lifestyle over 12 months, and whether viral marketing techniques can be used to disseminate the program on a mass scale.
What Cost-effective Built Environment Interventions Would Create Healthy, Liveable And Equitable Communities In Australia, And What Would Facilitate These Being Translated Into Policy And Practice?
Funder
National Health and Medical Research Council
Funding Amount
$2,658,832.00
Summary
This CRE involves collaboration between a multi-disciplinary research team across Australia working with policy-makers covering planning, urban design, transport planning and health. It will identify the most cost-effective built environment interventions required to create healthy, liveable, and equitable communities. Factors that influence research findings being translated into urban planning policy and practice will be examined and tools to assist changes to policy and practice developed.
Ultradian rhythms in basal metabolism; relationship to thermoregulation, cardiovascular function and behavioural arousal. Results from this project will be of basic theoretical biological importance, and may well provide a foundation for understanding basal metabolic regulation and its link with cardiovascular function. Our findings may provide a new foundation for discovering strategies that alter basal metabolic rate in a manner that improves health and reduces the incidence of obesity related ....Ultradian rhythms in basal metabolism; relationship to thermoregulation, cardiovascular function and behavioural arousal. Results from this project will be of basic theoretical biological importance, and may well provide a foundation for understanding basal metabolic regulation and its link with cardiovascular function. Our findings may provide a new foundation for discovering strategies that alter basal metabolic rate in a manner that improves health and reduces the incidence of obesity related disease such as heart attack and stroke. Thus this research proposal is of special relevance to National Research Priority 2: Promoting and Maintaining Good Health. Obesity and obesity-related medical conditions particularly affect older people, so that our research is also highly relevant to National Research Priority 2 sub-areas: Ageing well, Ageing productively.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100223
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Characterisation of visceral afferent spinal cord pathways. Sensory nerves in the gut wall are key mediators of chronic visceral pain. This project will characterise how sensory nerves supplying the bowel connect to the spinal cord and the spinal circuits mediating pain perception, providing information to identify sensory pathways underlying visceral pain.