Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already i ....Why do only some exotics become invasive? Combining ecological and genomic approaches to address alternative hypotheses in a recent Australian weed. This project will specifically test alternative hypotheses about how weeds become invasive. As invasive weeds affect both agricultural and native ecosystems equally, research on understanding the mechanisms of weed invasion is critical. Outcomes will benefit Australia by allowing better prioritisation of management against exotic plants already in the country by providing predictive tools to estimate likelihood of spread. For formal Pest Risk Analysis by regulators (eg Biosecurity Australia), our project will provide genomic tools by which the potential weediness of a regulated plant can be assessed through genetic screening, and forms part of an international effort to identify 'weedy genes'. Read moreRead less
Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the forma ....Defining the earliest events in lymphatic vasculature formation from veins. Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the formation of this essential vertebrate tissue. Ultimately, this is expected to provide new knowledge in stem and precursor cell differentiation, the evolution of complex organ systems and tissue formation. Outcomes may impact on future biotechnology in the areas of tissues engineering, stem cell differentiation and regeneration.Read moreRead less
Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understan ....Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understanding of how decision-making evolves in healthy ageing, and a tool based on genetic scores and computational modelling to predict an individual's trajectory of cognitive function. This could help identify individuals who are at risk for cognitive decline, which could then inform better interventions.Read moreRead less
'Just right' job design: A new model using the Goldilocks paradigm. This proposal will generate new knowledge about designing jobs with the right amount of human movement. Prolonged sitting is now a serious work hazard that contributes to cardiovascular risk and obesity. The high incidence of these conditions in many work systems, such as rail, also presents a critical safety hazard due to threat of sudden incapacity while driving. Expected project outcomes are a ‘Just Right’ Job Design model sh ....'Just right' job design: A new model using the Goldilocks paradigm. This proposal will generate new knowledge about designing jobs with the right amount of human movement. Prolonged sitting is now a serious work hazard that contributes to cardiovascular risk and obesity. The high incidence of these conditions in many work systems, such as rail, also presents a critical safety hazard due to threat of sudden incapacity while driving. Expected project outcomes are a ‘Just Right’ Job Design model showing how tasks can be designed to enhance safety and health while maintaining productivity, and in the unlikeliest of workplaces. This will provide significant benefits for the many working Australians whose safety and health are compromised by exposure to prolonged sitting in seemingly intractable environments.Read moreRead less
Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the ....Attentional asymmetries for navigation in healthy and clinical groups. This project plans to investigate how differences in attentional capacity between the left and right sides of the brain affect the ability to walk or manoeuvre vehicles between obstacles. To navigate our environment and avoid obstacles, we need to attend to stimuli that are important and ignore those that are not. Unfortunately, the brain’s attentional capacity is limited, which can result in errors and collisions. Using the techniques of cognitive neuroscience, the project aims to provide a better understanding of the cognitive and neural mechanisms that govern attention in an applied setting. It expects to identify the factors that exacerbate lapses in attention and collisions. The effect of everyday impediments such as mobile phones, alcohol and fatigue will be investigated together with means of minimising these attentional lapses and improving safety.Read moreRead less
Square Eyes or All Lies? Understanding Children's Exposure to Screens. This project will examine Australian parents’ number one concern about their children’s health and behaviour – their interactions with electronic screens. Current screen time guidelines are based on low-quality evidence and lack the nuance required to address this complex issue. This project will use innovative technology to resolve these weaknesses. Wearable cameras will measure what children are doing on screens, and where, ....Square Eyes or All Lies? Understanding Children's Exposure to Screens. This project will examine Australian parents’ number one concern about their children’s health and behaviour – their interactions with electronic screens. Current screen time guidelines are based on low-quality evidence and lack the nuance required to address this complex issue. This project will use innovative technology to resolve these weaknesses. Wearable cameras will measure what children are doing on screens, and where, when, and how long they are doing it. The project will also investigate how screen time impacts children’s development and how it is influenced by their environment. This evidence will benefit children by improving screen time guidelines, and help parents understand the impact of screen time on children’s development.
Read moreRead less
Sleepy and sitting: a dual curse for the modern workforce? This project aims to generate new knowledge about the impact of inadequate sleep and prolonged sitting on health markers and performance. Many workers, particularly those working outside standard hours, experience both prolonged sitting and inadequate sleep. Expected outcomes of this project include critical evidence to address the dual burden experienced by a large population of workers who are both sleepy and sitting. This should provi ....Sleepy and sitting: a dual curse for the modern workforce? This project aims to generate new knowledge about the impact of inadequate sleep and prolonged sitting on health markers and performance. Many workers, particularly those working outside standard hours, experience both prolonged sitting and inadequate sleep. Expected outcomes of this project include critical evidence to address the dual burden experienced by a large population of workers who are both sleepy and sitting. This should provide significant benefits for the many working Australians whose health and safety is compromised due to their exposure to inadequate sleep and prolonged sitting. It will also contribute to the evidence-base for workplace policies and public health guidelines.Read moreRead less
Sleeping with one ear open: the impact on sleep and waking function. The aim of the project is to assess the impact 'on-call' work has on sleep, stress, and next day performance. Two million Australians are on-call providing essential 24-hour services including emergency response. While sleep during on-call periods is disrupted when a call occurs, some research suggests that sleeping with one ear open waiting for a call may disrupt sleep even if no call occurs. If on-call sleep is less restorati ....Sleeping with one ear open: the impact on sleep and waking function. The aim of the project is to assess the impact 'on-call' work has on sleep, stress, and next day performance. Two million Australians are on-call providing essential 24-hour services including emergency response. While sleep during on-call periods is disrupted when a call occurs, some research suggests that sleeping with one ear open waiting for a call may disrupt sleep even if no call occurs. If on-call sleep is less restorative, then individuals are at risk of performance impairment and adverse health outcomes. This project aims to answer questions about the magnitude of sleep disruption when on-call, the mechanisms for any disruption, and impact on waking function.Read moreRead less
Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
Retirement activity planning: a randomised controlled trial. Retirement is a life transition where people must rethink the way they use their time, but little thought is given to planning for this. This project will assess the effect of systematic pre-retirement activity planning on use of time after retirement, with an emphasis on physical activity and sedentary behaviours.