Effects Of RHDL On Diabetes In TRAIL-deficient Mice.
Funder
National Health and Medical Research Council
Funding Amount
$294,892.00
Summary
Diabetes is a chronic disease affecting 275 people daily in Australia. People with diabetes have a 2-4 fold greater risk for developing cardiovascular disease (CVD). TRAIL (TNF-related apoptosis-inducing ligand) can promote cell growth and death selectively. High density lipoproteins are shown to protect against diabetes and CVD. Understanding the mechanism(s) that mediate this process may lead to the design of therapeutic agents to reduce suffering of patients with diabetes and CVD.
Investigating The Utility Of Therapeutic Drug Monitoring Of Beta-lactam Antibiotics In Hospitalised Patients
Funder
National Health and Medical Research Council
Funding Amount
$215,887.00
Summary
The appropriate dosing of antibiotics for patients admitted to hospital is based on broad guidelines derived from studies in healthy volunteers or in patients that may have different types of infections. Minor changes in the clinical state of the patients can require significant dosing adjustments. The best way to guarantee appropriate antibiotic therapy is to individualize doses based on blood concentration data. We aim to determine the utility of dose adjustment in hospitalized patients.
Exploring The Role Of The Bcl-2 Family In Haematopoiesis And Haematopoietic Malignancy
Funder
National Health and Medical Research Council
Funding Amount
$190,980.00
Summary
Chronic Lymphocytic Leukaemia and Non-Hodgkin Lymphoma comprise the majority of blood cancers and are both disease in which the cell death pathway plays a vital role in both the development of the cancer cell and the resistance to chemotherapy. This project aims to examine the mechanisms of cancer in these tumours focussing on lymphoid cancers, and examine the role of new treatments targeting this pathway.