Coupling biophotonic modalities with machine based recognition systems for disease diagnosis. This project will develop new ways to diagnose canine cancer, malaria and atherosclerosis using infrared-based technology and sophisticated pattern recognition techniques in the hope to discover infrared biomarkers that will lead to early diagnosis of the disease and ultimately save lives.
Proteotyping for the rapid identification of pandemic influenza. Future influenza pandemics will develop more rapidly providing a relatively short window with which to survey and assess the nature of the virus and administer effective treatments. Application of a new proteotyping approach will allow strains of pandemic potential to be characterised more directly and rapidly than current surveillance methods.
Predicting the evolution of the influenza virus on mass. Understanding viral reassortment is essential for the development of efficacious vaccines and to prepare for a future influenza pandemic. The research will improve our ability to monitor the evolution of reassorted influenza virus strains using new computer algorithms in concert with the application of bioinformatics and analytical technologies.
Multiscale integration of imaging and omics data. This project aims to integrate multiscale imaging and molecular data to characterise disease in patients. Modern healthcare needs to embrace ‘big (health) data’s potential to address an ageing population’s increasing healthcare demands and the inefficiencies and waste in patient treatment. This project expects to pioneer basic science research in methodologies to integrate, correlate and then derive knowledge from multi-scale data, to characteris ....Multiscale integration of imaging and omics data. This project aims to integrate multiscale imaging and molecular data to characterise disease in patients. Modern healthcare needs to embrace ‘big (health) data’s potential to address an ageing population’s increasing healthcare demands and the inefficiencies and waste in patient treatment. This project expects to pioneer basic science research in methodologies to integrate, correlate and then derive knowledge from multi-scale data, to characterise the mechanisms of disease in individual patients, in space and time. Its integrated model is expected to form the basis of a framework for individualised patient disease analysis.Read moreRead less
Decoding miRNA regulated genetic circuits. This project will aim to develop a much better understanding of how the process of making proteins from genes is regulated, and will develop scientific software capable of predicting how a cell will respond to changes in this regulation. The results will have widespread use, including assistance in deciding the best treatments for genetic diseases.
Discovery Early Career Researcher Award - Grant ID: DE120102503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical sam ....Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical samples.Read moreRead less
Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions ....Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.Read moreRead less
Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell typ ....Bioinks for the 3D printing of cells made from off-the-shelf components. This project aims to develop a simple method for creating complex, multiple-cell-type three-dimensional (3D) cell cultures for in-vitro cell based assays. Using 3D printing technology, this project will develop a versatile polymer system, made from entirely commercially available components, that gels upon printing and has functionality to assist cells in adhering, growing and migrating. The 3D printing of multiple cell types will provide biological scientists with more realistic in-vitro cell assays to those found in-vivo. Applications of the research are in cell biology, studying diseases and developing new drugs.Read moreRead less