Smart self-propelled nanoreactors for catalytic environmental remediation. This project aims to develop nanomaterial design and technology to enable the applications of nanotechnology for environmental remediation. Various nanomotors with different asymmetric structures will be fabricated and tested for catalytic and photocatalytic degradation of aqueous pollutants. The physicochemical properties, motion behaviour and catalytic performance will be comprehensively investigated. The outcomes of th ....Smart self-propelled nanoreactors for catalytic environmental remediation. This project aims to develop nanomaterial design and technology to enable the applications of nanotechnology for environmental remediation. Various nanomotors with different asymmetric structures will be fabricated and tested for catalytic and photocatalytic degradation of aqueous pollutants. The physicochemical properties, motion behaviour and catalytic performance will be comprehensively investigated. The outcomes of the project will underpin the development of green technologies for sustainable energy conversion and water treatment. This will provide significant benefits, putting Australia in a leading position in the sustainable development of nanotechnology for sustainable energy supply and transformation as well as environmental and biomedical applications.Read moreRead less
Catalytic Degardation of Emerging Microplastic Pollutants. This project aims to develop robust and low-cost nanocarbon hybrids and advanced remediation technology to address globally emerging microplastic contaminations. The project expects to boost innovations in development of novel magnetic nanomaterials, process of microplastic purification, and green catalysis. Expected outcomes of this project will include efficient strategies in materials fabrication and a cutting-edge nanotechnology. The ....Catalytic Degardation of Emerging Microplastic Pollutants. This project aims to develop robust and low-cost nanocarbon hybrids and advanced remediation technology to address globally emerging microplastic contaminations. The project expects to boost innovations in development of novel magnetic nanomaterials, process of microplastic purification, and green catalysis. Expected outcomes of this project will include efficient strategies in materials fabrication and a cutting-edge nanotechnology. The success of the project will underpin the scientific bases of carbocatalysis, provide significant benefits to the Australian industry and society for a sustainable future with clean water, and increase the leading capacity of Australia in fundamental research and frontier technology.Read moreRead less
Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocata ....Controllable Synthesis of Defects in Catalysts for Electrocatalysis . This project aims to address the most critical issue of electrocatalysis: identification of active sites for carbon-based metal free catalysts (CMFCs). Through the development of new methodologies, this proposal will, for the first time, controllably synthesise the vacancy defects that are the major active sites for CMFCs. The expected outcomes from this project include in-depth understanding of the fundamentals of electrocatalysis: the reactivity of active sites and the catalytic performance with the number of active sites; which will not only significantly advance knowledge but also achieve breakthrough technologies that greatly benefit to the society and economy both for Australia and worldwide.Read moreRead less
Integrated photo and thermal catalysis for economic carbon dioxide conversion to fuels. The project aims to develop an integrated process for simultaneously photo- and thermal-catalytic conversion of carbon dioxide and water vapour to hydrocarbon fuels and chemicals using solar light and waste heat from flue gas. This project will design and make multi-functional catalysts based on zirconium metal organic frameworks, incorporating quantum dots and metal nanoclusters. This project is expected to ....Integrated photo and thermal catalysis for economic carbon dioxide conversion to fuels. The project aims to develop an integrated process for simultaneously photo- and thermal-catalytic conversion of carbon dioxide and water vapour to hydrocarbon fuels and chemicals using solar light and waste heat from flue gas. This project will design and make multi-functional catalysts based on zirconium metal organic frameworks, incorporating quantum dots and metal nanoclusters. This project is expected to develop an advanced materials system, reduce carbon dioxide and use it to produce fuel, and harness solar energy. The project should advance Australia’s leading role in reducing carbon emission, and producing clean energy and nanotechnology.Read moreRead less
Development of Pyrrolopyrimidines as Inhibitors of ATP-Binding Proteins. This project seeks to generate analogues of natural products that have been found to be active against cancer cells and tropical parasites. The new materials produced by this project will aid in the study of biochemical processes involved in diseases such as cancer and lymphatic filariasis, thus leading the way to development of these compounds as potential treatments for such diseases.
Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Pr ....Designing microarray experiments. Microarrays are powerful tools for surveying the expression levels of many thousands of genes simultaneously. They belong to the new genomics technologies which have important applications in the biological, pharmaceutical and agricultural sciences. There are many sources of uncertainty in microarray experimentation and good statistical designs are essential for ensuring that the effects of interest to scientists are accurately and precisely measured. This Project will develop novel designs for microarray experiments and focus on the advancement of topics crucial to Australia's success in technological research.
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Genetic dissection of a regulatory deubiquitlyation network. The potential impact of this work is widespread, because although it is known that ubiquitlyation has regulatory consequences in multicellular eukaryotes, individual networks have not been completely described in higher eukaryotes. Knowledge gained about fundamental processes in the A. nidulans model system is directly applicable to fungi used in biotechnology in the food, beverage, enzyme and pharmaceutical production industries, and ....Genetic dissection of a regulatory deubiquitlyation network. The potential impact of this work is widespread, because although it is known that ubiquitlyation has regulatory consequences in multicellular eukaryotes, individual networks have not been completely described in higher eukaryotes. Knowledge gained about fundamental processes in the A. nidulans model system is directly applicable to fungi used in biotechnology in the food, beverage, enzyme and pharmaceutical production industries, and to fungal pathogens. Since the fungal genes that form the basis of this project are conserved in higher eukaryotes including humans, the knowledge will be transferable to these systems. A further benefit that cannot be overstated is the research education and training opportunities provided.
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Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpi ....Novel Mass Spectrometric Approaches to the Study of Protein-Protein Interactions. Protein-protein interactions mediate all fundamental cellular processes, yet the structural complexity of protein assemblies mean they are often difficult to characterise using traditional analytical methods. This project will develop and demonstrate novel mass spectrometric approaches towards a molecular level description of the structure and interactions of biological protein complexes, which in turn may underpin the rational design of drugs for the treatment of a range of human health conditions. This project will also provide training of young researchers to the highest international standards in mass spectrometry and protein science, for benefit to Australian industry and research.Read moreRead less
Adaptation to life in the dark: genomic analyses of blind beetles. This project aims to utilise a unique Australian model system based on multiple, independently-evolved subterranean water beetles to explore the adaptive and regressive changes in the genome that occur when surface species colonise subterranean habitats. This project focuses on the evolution of Heat Shock protein (Hsp) genes that play critical roles in adaptation to environmental stress and the process of de-canalisation, the rel ....Adaptation to life in the dark: genomic analyses of blind beetles. This project aims to utilise a unique Australian model system based on multiple, independently-evolved subterranean water beetles to explore the adaptive and regressive changes in the genome that occur when surface species colonise subterranean habitats. This project focuses on the evolution of Heat Shock protein (Hsp) genes that play critical roles in adaptation to environmental stress and the process of de-canalisation, the release of cryptic genetic variation that can allow novel morphologies to evolve in new environments. The project expects to provide further understanding of how species may potentially adapt to environmental stresses in the future, including climate change.Read moreRead less
Is regressive evolution associated with loss of gene function in subterranean animals? This project aims to investigate a fundamental biological process: the evolutionary basis for how non-functional characters, such as eyes in subterranean animals, are lost. It will use a unique model system based on eyeless water beetles, and utilise novel new genomic tools to test whether loss of characters results from gene inactivation.