Australian Laureate Fellowships - Grant ID: FL140100025
Funder
Australian Research Council
Funding Amount
$2,617,462.00
Summary
The physical brain: emergent, multiscale, nonlinear, and critical dynamics. The physical brain: emergent, multiscale, nonlinear, and critical dynamics. This project aims to transform the understanding of the structure and function of the brain as a complex physical system. It aims to reveal and unify new aspects of information processing, transitions in conscious state, and nonlinear brain interactions by translating and applying concepts and methods from physics and mathematics. It will treat b ....The physical brain: emergent, multiscale, nonlinear, and critical dynamics. The physical brain: emergent, multiscale, nonlinear, and critical dynamics. This project aims to transform the understanding of the structure and function of the brain as a complex physical system. It aims to reveal and unify new aspects of information processing, transitions in conscious state, and nonlinear brain interactions by translating and applying concepts and methods from physics and mathematics. It will treat brain structure and dynamics together to address emergent phenomena like waves and patterns on multiple scales, treating waves as equal participants alongside neurons. Innovative predictions of brain phenomena will aim to be verified against data and used to understand brain networks, dynamics, and the physical phenomena underlying information processing and consciousness.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100005
Funder
Australian Research Council
Funding Amount
$3,350,000.00
Summary
CellMaps for cell fate decision making systems. The cell is the fundamental unit exhibiting the hallmarks of life. The cell is also a fantastically intricate and complex system: its behaviour is shaped by molecular networks and processes that regulate cellular physiology, and the response of the cell to its environment. This Laureate Fellowship aims to describe and make sense of this complexity mathematically. At this sub-cellular level stochasticity and complex non-linear feedbacks are all perv ....CellMaps for cell fate decision making systems. The cell is the fundamental unit exhibiting the hallmarks of life. The cell is also a fantastically intricate and complex system: its behaviour is shaped by molecular networks and processes that regulate cellular physiology, and the response of the cell to its environment. This Laureate Fellowship aims to describe and make sense of this complexity mathematically. At this sub-cellular level stochasticity and complex non-linear feedbacks are all pervasive. Building on recent advances in mathematics, statistics, theoretical physics, and data science will result in mathematical models of cells, CellMaps, that will generate mechanistic insights into the fundamental dynamical processes underlying cell fate decision making and differentiation. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL140100027
Funder
Australian Research Council
Funding Amount
$2,898,150.00
Summary
Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of du ....Under the hood: single-molecule studies of multi-protein machines. Under the hood: single-molecule studies of multi-protein machines. Living cells are filled with complex protein machines that are responsible for the molecular processes supporting life. This project is aimed towards the development of physical tools that enable the study of these protein complexes at the level of single molecules. This project aims to study the protein machinery responsible for DNA replication, the process of duplicating genomic information before cell division. By making real-time single-molecule movies of the replication process, this project aims to unravel the molecular mechanisms of this important process and provide the knowledge required to understand disease mechanisms and catalyse drug development.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL0992138
Funder
Australian Research Council
Funding Amount
$3,100,000.00
Summary
Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial ....Towards antibacterials without resistance. Innovative automation technologies will be used to create and investigate a revolutionary new approach to disable pathogenic superbugs, bacteria resistant to multiple antibiotics. The chemicals created and proteins evaluated in this research program will advance fundamental knowledge about the molecular weapons that bacteria produce to cause disease; deliver social and economic benefits to Australia through the development of potential new antibacterial treatments; contribute to Australia's continued international leading role in drug discovery research; enhance international links and attract industry investment in Australia; and provide a stimulating research training environment to inspire and motivate the next generation of scientists.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL220100184
Funder
Australian Research Council
Funding Amount
$2,897,256.00
Summary
Next-generation maps and models of the human brain. This project aims to develop a new framework for understanding how the anatomy of the brain shapes its function and influences individual differences in human behaviour. The project expects to develop innovative methods for mapping and modelling human brain function by combining techniques from neuroscience, physics, informatics, psychology, and genetics. Expected outcomes include new tools for analysing brain imaging data, new models of brain ....Next-generation maps and models of the human brain. This project aims to develop a new framework for understanding how the anatomy of the brain shapes its function and influences individual differences in human behaviour. The project expects to develop innovative methods for mapping and modelling human brain function by combining techniques from neuroscience, physics, informatics, psychology, and genetics. Expected outcomes include new tools for analysing brain imaging data, new models of brain structure and function, an understanding of how genes shape brain architecture, and a comprehensive characterization of how individual differences in brain organization relate to behaviour. These outcomes should benefit our understanding of how the brain works and of the biological basis of behaviour.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100131
Funder
Australian Research Council
Funding Amount
$2,496,651.00
Summary
Geoengineering the Southern Ocean? A transdisciplinary assessment. Geoengineering the Southern Ocean? A transdisciplinary assessment. The project aims to comprehensively evaluate the feasibility of offsetting climate change by using geoengineering to boost carbon dioxide removal by Southern Ocean microbes. With existing polar datasets as a platform, the project would combine experiments and modelling to quantify carbon dioxide removal and critically assess the economic feasibility and side effec ....Geoengineering the Southern Ocean? A transdisciplinary assessment. Geoengineering the Southern Ocean? A transdisciplinary assessment. The project aims to comprehensively evaluate the feasibility of offsetting climate change by using geoengineering to boost carbon dioxide removal by Southern Ocean microbes. With existing polar datasets as a platform, the project would combine experiments and modelling to quantify carbon dioxide removal and critically assess the economic feasibility and side effects of geoengineering. Anticipated outcomes include a framework for governance of future research and informed national/international policy on using geoengineering to mitigate climate change.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL150100106
Funder
Australian Research Council
Funding Amount
$2,951,945.00
Summary
Bio-metrology and modelling of a complex system: the malaria parasite. Bio-metrology and modelling of a complex system: the malaria parasite: This fellowship project aims to develop a cross-disciplinary program to measure, model and manipulate a complex cellular system — sexual differentiation of the human malaria parasite. Combining life and physical sciences with powerful imaging techniques, the project seeks to develop quantitative biochemical, biophysical and modelling techniques to probe a ....Bio-metrology and modelling of a complex system: the malaria parasite. Bio-metrology and modelling of a complex system: the malaria parasite: This fellowship project aims to develop a cross-disciplinary program to measure, model and manipulate a complex cellular system — sexual differentiation of the human malaria parasite. Combining life and physical sciences with powerful imaging techniques, the project seeks to develop quantitative biochemical, biophysical and modelling techniques to probe a complex system in a way previously not possible. It expects to integrate and correlate thousands of measurements of the dynamic processes inside cells and use these datasets to generate rigorous and sophisticated mathematical models that can predict drivers of commitment for transformation of the parasite to a sexual phase in preparation for transmission to mosquitoes. This holistic approach hopes to deliver new biotechnology and biomedical outcomes, including new ways to combat disease in livestock and humans.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL210100258
Funder
Australian Research Council
Funding Amount
$3,331,707.00
Summary
Understanding how bacteria adapt and function in the complex gut ecosystem. This project aims to investigate the role of the gut ecosystem in defining the structure and function of microbes. Given that one of the current challenges in microbiology is our inability to study individual microbes directly from complex, multi-microbial niches, this project aims to develop multidisciplinary methods to study microbes in their native state, to understand how they adapt to live in the gut. This understan ....Understanding how bacteria adapt and function in the complex gut ecosystem. This project aims to investigate the role of the gut ecosystem in defining the structure and function of microbes. Given that one of the current challenges in microbiology is our inability to study individual microbes directly from complex, multi-microbial niches, this project aims to develop multidisciplinary methods to study microbes in their native state, to understand how they adapt to live in the gut. This understanding should provide fundamental insights into adaptation mechanisms that lead to bacterial proliferation, disease and antibiotic resistance. As well as enhancing interdisciplinary collaborations, this work should provide economic benefits by contributing to improved gut health of animals, and more efficient food production.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100100
Funder
Australian Research Council
Funding Amount
$3,300,000.00
Summary
Forces in Nature: Tissue mechanics and cell sociology. Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdis ....Forces in Nature: Tissue mechanics and cell sociology. Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia’s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery. Read moreRead less
Australian Laureate Fellowships - Grant ID: FL130100119
Funder
Australian Research Council
Funding Amount
$3,110,000.00
Summary
New views of life: quantum imaging in biology. This project will create and apply new technology, based on the quantum properties of diamond, to attack important problems in biology; from how cells differentiate at the beginning of life, to understanding brain function. The results of this project will directly benefit society through the development of new technology for nano-medicine and drug discovery.