Discovery Early Career Researcher Award - Grant ID: DE170100785
Funder
Australian Research Council
Funding Amount
$345,491.00
Summary
Mathematical and statistical modelling of antimalarial drug action. This project aims to develop a mathematical model to optimise global antimalarial treatment policy. Malaria-causing parasites are resistant to the most potent antimalarial drug available. If left unaddressed, a catastrophic rise in global malaria incidence and mortality could occur. Changes to global antimalarial treatment policy increasingly rely on mathematical models, but they do not encompass recent breakthroughs in antimala ....Mathematical and statistical modelling of antimalarial drug action. This project aims to develop a mathematical model to optimise global antimalarial treatment policy. Malaria-causing parasites are resistant to the most potent antimalarial drug available. If left unaddressed, a catastrophic rise in global malaria incidence and mortality could occur. Changes to global antimalarial treatment policy increasingly rely on mathematical models, but they do not encompass recent breakthroughs in antimalarial drug action and the immune response. This project’s model is expected to improve antimalarial drug dosing regimens and control the spread of antimalarial drug resistance.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100046
Funder
Australian Research Council
Funding Amount
$387,000.00
Summary
Fortifying our digital economy: advanced automated vulnerability discovery. This project aims to enable security researchers to detect critical vulnerabilities in large software systems with maximal efficiency, cost-effectively, and with known statistical accuracy. The aim is to develop advanced high-performance fuzzers that effectively thwart malware attacks, ransomware epidemics, and cyber terrorism by exposing security flaws before they can commence. The project will employ a well-established ....Fortifying our digital economy: advanced automated vulnerability discovery. This project aims to enable security researchers to detect critical vulnerabilities in large software systems with maximal efficiency, cost-effectively, and with known statistical accuracy. The aim is to develop advanced high-performance fuzzers that effectively thwart malware attacks, ransomware epidemics, and cyber terrorism by exposing security flaws before they can commence. The project will employ a well-established statistical framework utilised in ecology research to provide fundamental insights to boosting the efficiency of software vulnerability discovery, and on the trade-off between investing more resources and gaining better cyber security guarantees. As our reliance on new technologies is ever growing, this project equips Australia to curb cyber crime cost-effectively.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101520
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Diet, variance and individual variability in life-history. This project aims to provide biologists with novel statistical tools that will shift analytical paradigms. In many species, dietary restrictions increase average lifespan, and affect average rates of growth and reproduction, also known as ‘life history’. The use of recently developed tools has shown that individual variability in life history also appears to increase under dietary restrictions. This project will explore the effects of di ....Diet, variance and individual variability in life-history. This project aims to provide biologists with novel statistical tools that will shift analytical paradigms. In many species, dietary restrictions increase average lifespan, and affect average rates of growth and reproduction, also known as ‘life history’. The use of recently developed tools has shown that individual variability in life history also appears to increase under dietary restrictions. This project will explore the effects of diet composition on variability in life-history traits, and the factors driving this variation. This is expected to improve the prediction of the effects of changing nutritional environments.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100976
Funder
Australian Research Council
Funding Amount
$307,058.00
Summary
Identifying parent-of-origin effects and their impact on complex traits. This project aims to systematically identify genetic variants whose effects depend on whether they were inherited from the mother or the father, and to assess their impact on complex human traits. Most gene mapping studies to date assume that the effects of genetic variants are equal regardless of the parent of origin, thus have not explored this source of genetic variation. However, animal studies indicate that parent-of-o ....Identifying parent-of-origin effects and their impact on complex traits. This project aims to systematically identify genetic variants whose effects depend on whether they were inherited from the mother or the father, and to assess their impact on complex human traits. Most gene mapping studies to date assume that the effects of genetic variants are equal regardless of the parent of origin, thus have not explored this source of genetic variation. However, animal studies indicate that parent-of-origin specific effects (POEs) are important contributors to variability of developmental and behavioural traits. Leveraging genetic and epigenetic data from some of the world’s largest cohorts, this project will improve our understanding of POEs on complex human traits related to early development, growth and behaviour.Read moreRead less