Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100043
Funder
Australian Research Council
Funding Amount
$435,279.00
Summary
High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super ....High-throughput portable and wearable device fabrication facility. This project aims to establish a fabrication and characterisation facility for high-throughput production of portable, wearable and stretchable biomedical devices to accelerate the design–fabrication–evaluation process and save ‘trial-and-error’ costs during optimisation turnaround. It will apply computer-aided design for the programmable synthesis of hybrid materials for high-throughput screening of disease biomarkers, and super-solution imaging of single molecules in live cells. This facility will provide capability for researchers pursuing industry transformation and other initiatives in the development of advanced materials, biomolecular sciences, nanotechnology, photonics and device engineering.Read moreRead less
Bacterial detection and infection control using tethered membranes. This project will develop a rapid diagnostic tool to detect live bacteria, which will subsequently reduce risk of infection, increase efficiencies in patient care and hospital management, and produce savings in health care budgets. It also has the potential to save lives through addressing the serious and growing problem of antibiotic resistance.
Discovery Early Career Researcher Award - Grant ID: DE220100311
Funder
Australian Research Council
Funding Amount
$383,982.00
Summary
Shining nanoparticles for single microRNA detection in microfluidics. This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The ....Shining nanoparticles for single microRNA detection in microfluidics. This project aims to extensively study the interface between nanoparticles and nucleic acids. It sets out to produce a novel ultrasensitive high-performance biosensing platform that will combine luminescent nanoparticles with microfluidics in a digital assay. This portable platform will detect biological fingerprints, or microRNAs, at a single-molecule level, delivering unprecedented levels of sensitivity and specificity. The multiplexed platform has the potential to benefit the biomedical research of microRNAs and opens up a genuine commercialisation potential for portable biosensing of nucleic acids.Read moreRead less
Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the ....Development of an electrode for stimulation of a transplanted neosphincter. This project aims to develop a novel electrode as an integral component of a new treatment for severe stress urinary incontinence. Treatments for severe stress urinary incontinence are associated with complications and are not completely effective. The new electrode is designed to be activated by an implanted stimulator to control an innervated smooth muscle graft (the neosphincter) to regulate the flow of urine from the bladder. Project research into the design of the electrode will focus on providing safe, effective and efficient stimulation of the neosphincter, while ensuring minimal damage to the surrounding tissues and affording straightforward implantation at surgery.Read moreRead less
Development of an electrode assembly for the stimulation of a transplanted innervated smooth muscle sphincter. This project will design and assess a number of different electrode designs for use in a medical device being developed for the treatment of severe stress urinary incontinence. The project will identify an optimal electrode design, which will be used in future clinical trials of the device.
Contribution of Comammox Process to Sustainable Wastewater Treatment. This project aims to understand the versatility, activity and physiological features of comammox bacteria, the newly-discovered complete nitrifiers, in Australian wastewater treatment systems, and to model and evaluate their contributions to biological nitrogen removal process. Nitrogen transformations are crucial microbial processes in the wastewater treatment ecosystems, with nitrification largely responsible for ammonium ox ....Contribution of Comammox Process to Sustainable Wastewater Treatment. This project aims to understand the versatility, activity and physiological features of comammox bacteria, the newly-discovered complete nitrifiers, in Australian wastewater treatment systems, and to model and evaluate their contributions to biological nitrogen removal process. Nitrogen transformations are crucial microbial processes in the wastewater treatment ecosystems, with nitrification largely responsible for ammonium oxidation but comammox previously overlooked. The expected outcomes will develop new knowledge on the comammox process and provide novel insight and technological solution to refine strategies to manipulate nitrification processes for achieving improved biological nitrogen removal and sustainable wastewater management.Read moreRead less
Developing an integrated device for on-farm detection of sugarcane diseases. Pathogenic organisms cause yield losses of more than $150M pa to the Australian sugarcane industry and many millions more worldwide. Partnering with Sugar Research Australia, this project aims to develop a novel on-farm diagnostic device, comprising new nanotechnology and magnetism-induced microfluidics with naked eye observation and electrochemical detection. This device is expected to enable improved disease managemen ....Developing an integrated device for on-farm detection of sugarcane diseases. Pathogenic organisms cause yield losses of more than $150M pa to the Australian sugarcane industry and many millions more worldwide. Partnering with Sugar Research Australia, this project aims to develop a novel on-farm diagnostic device, comprising new nanotechnology and magnetism-induced microfluidics with naked eye observation and electrochemical detection. This device is expected to enable improved disease management strategies through the prediction of potential risks and rapid and effective actions to mitigate impending yield loss. In turn productivity and sustainability of Australia’s sugar industry will be enhanced. The new platform device has great potential for improved disease management in other crops in Australia and globally.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100177
Funder
Australian Research Council
Funding Amount
$440,000.00
Summary
National Live Cell Scanning Platform for Nanoparticle Tracking. National live cell scanning platform for nanoparticle tracking: The aim of the project is to establish a multi-disciplinary, multi-user, self-correlated scanning facility to reach a new level of temporal and spatial precision for real-time tracking and quantification of biomolecules and nanoparticles within large populations of living cells. The facility will consist of a live-cell spinning-disc confocal microscope, a correlated bio ....National Live Cell Scanning Platform for Nanoparticle Tracking. National live cell scanning platform for nanoparticle tracking: The aim of the project is to establish a multi-disciplinary, multi-user, self-correlated scanning facility to reach a new level of temporal and spatial precision for real-time tracking and quantification of biomolecules and nanoparticles within large populations of living cells. The facility will consist of a live-cell spinning-disc confocal microscope, a correlated biological atomic force microscope, and remote access facilities. It is expected that with superior optical characterisation and mechanical manipulation, the automated orthogonal scanning facility will open new avenues to reveal unprecedented information from biological and pathological processes. The collaborative facility will support world-class researchers in the multi-disciplinary areas of physical, material and life sciences, placing Australia at the forefront of nanoscale biophotonics.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH190100021
Funder
Australian Research Council
Funding Amount
$4,999,540.00
Summary
ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A ....ARC Research Hub to Combat Antimicrobial Resistance. The ARC ITRP Research Hub to Combat Antimicrobial Resistance takes on the global challenge of antimicrobial resistance (AMR) for Australia through a world-first partnership between industry, researchers, and end users. The AMR Hub fosters a pre-commercialisation environment to address both social and laboratory-based preclinical challenges to provide a highly integrated diagnostic, pharmaceutical and end user solution to the problem of AMR. A goal of the Hub is to support the development of new molecular diagnostic technology, improve the processes for identifying potential antibiotic compounds and assess and advise on antimicrobial stewardship with a vision to transform social and health outcomes globally.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100667
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Removing a Key Barrier for Autotrophic Nitrogen Removal from Wastewater. This project aims to develop new technology to enable stable autotrophic nitrogen removal from domestic wastewater. The technology selectively suppresses the growth of nitrite-oxidising bacteria using a by-product of wastewater treatment – free nitrous acid. Maximising energy recovery from wastewater and providing greenhouse gas neutral water services have been the targets of water utilities in Australia and worldwide. The ....Removing a Key Barrier for Autotrophic Nitrogen Removal from Wastewater. This project aims to develop new technology to enable stable autotrophic nitrogen removal from domestic wastewater. The technology selectively suppresses the growth of nitrite-oxidising bacteria using a by-product of wastewater treatment – free nitrous acid. Maximising energy recovery from wastewater and providing greenhouse gas neutral water services have been the targets of water utilities in Australia and worldwide. The project will potentially change wastewater management and bring economic, environmental and social benefits to water utilities.Read moreRead less