3D Hypersonic Shock-Turbulent-Boundary-Layer Interactions. Shock-wave turbulent-boundary-layer interactions occur on hypersonic flight vehicles and can lead to high heating and increased drag. This is a paramount design issue that needs addressing. We aim to understand and quantify fundamental phenomena occurring in such interactions using state-of-the-art instrumentation and wind-tunnel facilities. Surfaces will be heated to realistic flight temperatures to simulate accurately the flight enviro ....3D Hypersonic Shock-Turbulent-Boundary-Layer Interactions. Shock-wave turbulent-boundary-layer interactions occur on hypersonic flight vehicles and can lead to high heating and increased drag. This is a paramount design issue that needs addressing. We aim to understand and quantify fundamental phenomena occurring in such interactions using state-of-the-art instrumentation and wind-tunnel facilities. Surfaces will be heated to realistic flight temperatures to simulate accurately the flight environment and include effects not reproduced with cold models. The effects of 3D features of the interactions will lead to new understanding of how the flow develops through a combination of experiments and numerical simulations. Future designs of hypersonic flight vehicles will benefit from knowledge gained.Read moreRead less
Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and de ....Transcriptional regulation of erythropoiesis. The major expected outcome from this proposal will be development of a pipeline for the study of how transcription factors work at a genome level. There will be national benefit in the areas of Frontier Technologies, and Promoting and Maintaining Good Health. There will be specific outcomes with respect to development of tests for human blood diseases, future design of drugs to target the aberrant activities of transcription factors in genetic and degenerative diseases. Also, a strong bridge will be built upon the previous collaborations of the research teams in Brisbane and Pennsylvania, which will facilitate advanced teaching and training of Australian PhD and post-doctoral scientists.Read moreRead less
Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at ....Novel framework for optimising battery-cooling microchannel heat exchangers. Thermal overheating can affect the capacity, safety and life expectancy of batteries for renewable energy storage and electric vehicles. Microscale heat exchangers are a potential high-efficiency, low-bulk solution. This project aims to develop a novel computational methodology to optimise the design of those heat exchangers in which viscoelastic fluids are used to control flow instabilities and enhance heat transfer at the microscale. A new microscopic fluid physics model will provide data for an innovative neural network framework to optimise the working fluid conditions and microscale design, which could contribute to increased adoption of renewable energy technologies that are supported by microscale heat exchangers.Read moreRead less
Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxyge ....Expanding the scramjet operating envelope through oxygen enrichment. This project aims to investigate the benefits of expanding the operating envelope of scramjets to higher altitudes and speeds by enriching their fuel with oxygen. This is expected to enhance the performance and flexibility of hypersonic air-breathing engines designed to form the core of a more reliable and economical access to space system. Expected outcomes of this project are a validated understanding and mapping of how oxygen enrichment can augment scramjet thrust at high altitudes and speeds, and a performance evaluation of a launch system optimised for this approach. This could provide significant benefits to the performance of reusable, air-breathing launch technology, where Australia is leading the push towards commercialisation.Read moreRead less
Function and regulation of the Schlafen gene family: novel regulators of blood cell proliferation and function. The immediate outcomes of the proposed research will be in fundamental knowledge and understanding of important cellular and biological processes in which the Schlafen genes are involved. In particular, Schlafen genes are likely to play a role in inflammatory responses and in blood cell growth. These process clearly have relevance to a range of major human (and animal) diseases includ ....Function and regulation of the Schlafen gene family: novel regulators of blood cell proliferation and function. The immediate outcomes of the proposed research will be in fundamental knowledge and understanding of important cellular and biological processes in which the Schlafen genes are involved. In particular, Schlafen genes are likely to play a role in inflammatory responses and in blood cell growth. These process clearly have relevance to a range of major human (and animal) diseases including infectious disease, auto-immune disease and leukaemia, and thus a long-term outcome may be improved treatments for such disease. Read moreRead less