Selective Isolation And In Vivo Properties Of Dopamine Neurons Generated From Embryonic Stem Cells.
Funder
National Health and Medical Research Council
Funding Amount
$505,389.00
Summary
This research aims to develop a procedure that allows for the safe and effective use of stem cells as a therapy for Parkinson’s disease. It is based on the concept that new dopamine neurons, generated from stem cells, can be implanted into the brain of the patients in order to replace those lost to the disease, thereby improving motor function.
Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a Nat ....Innovative Technology for At-Scene Forensic Analysis using Microfluidics and Chemiluminescence. The major outcome of this project will be innovative reagents and strategies optimised for the detection of priority analytes such as drugs, explosives and chemical warfare agents. These will utilise a new technology platform based upon laboratory on a chip/microfluidics to enable the development of analytical methodologies suitable for use at crime scenes.This programme of research falls within a National Research Priority namely 'Protecting Australia from terrorism and crime'. Through our current forensic science research collaboration the outcomes will build significantly on Australia's existing strengths in rapid detection using new analytical technologies.Read moreRead less
Characterisation Of Human Embryonic Stem Cell Differentiation To Haematopoietic Progenitors And Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$638,856.00
Summary
Blood stem cells, which are found in the bone marrow, are currently used for treating human blood disorders including leukemia and lymphoma. However, for the majority of bone marrow transplant candidates, suitable donors cannot be found. Using embryonic stem cells, this project aims to define the conditions required to generate blood stem cells in the laboratory. The aim of the work is to provide a new source of blood stem cells that could be used in place of donor derived bone marrow.
Modelling Of Clinic And Ambulatory Blood Pressure On Cardiovascular Risk And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$133,957.00
Summary
Whilst ambulatory blood pressure monitoring data has been shown to be a good predictor of cardiovascular events, there remains controversy as to its utility in clinical practice. This project will use data from existing population and clinical cohort studies to examine the role of ambulatory blood pressure in risk assessment and hypertension management in Australia and around the globe. The findings are likely to have a major impact on clinical guidelines for hypertension management.
Understanding The Origins Of Neurogenic Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$668,914.00
Summary
Brain cells that control the cardiovascular system are thought to have stopped dividing by adulthood. We recently discovered that this is not the case. Our initial findings suggest that these nascent cells might be important for maintaining normal blood pressure. This work will allow us to elucidate the function of these nascent cells and how they integrate into the circuit that controls the cardiovascular system. Our findings will be fundamental for understanding diseases such as hypertension.
Reducing Morbidities In Preterm Growth Restricted Neonates.
Funder
National Health and Medical Research Council
Funding Amount
$687,214.00
Summary
Intrauterine growth restriction (IUGR) is a serious complication of pregnancy and occurs when fetal growth is abnormal, resulting in a fetus that is smaller than it should be for its given gestational age. IUGR babies are at much greater risk of many short and long-term adverse outcomes. This study investigates the role that adverse cardiovascular development plays in the progression of lung, heart and brain disease in preterm IUGR newborns.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989125
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest. The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental sustainability, development of new materials and designing molecules of therapeutic value on the basis of better understanding the relevant biological processes. This support will lead to maximizing the outcomes of numerous ....Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest. The proposed integrated facility will strongly support collaborative research in areas of high national priority. These are environmental sustainability, development of new materials and designing molecules of therapeutic value on the basis of better understanding the relevant biological processes. This support will lead to maximizing the outcomes of numerous projects already funded by the Australian Research Council which require accurate and highly sensitive analysis. This will improve the cost effectiveness of research funding and will further strengthen the outstanding reputation of Australia science worldwide.Read moreRead less
Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perfo ....Advanced micro analysis systems for environmental monitoring. Understanding of the behaviour of the nutrients controlling nuisance algae in water bodies is currently limited by the cost and logistics of collecting and analysing the large numbers of samples required.
This proposal describes the development and evaluation of portable multiparameter micro analysis systems that will be capable of high frequency measurements from a sampling vessel. This will enable environmental agencies to perform rapid on-site mapping of nutrients and other water quality parameters in large water bodies, intensive scale mapping of effluent mixing and dispersal zones, quick assessment of the impact of dredging and aquaculture, and compliance monitoring in effluent streams.
Read moreRead less
The Application of Polymer Inclusion Membranes for the Removal of Thiocyanate and Cyanide from Gold Ore Processing Wastewaters. The recovery of gold at Stawell Gold Mine can be improved by using cyanide and thiocyanate free water in the milling process. The aim of this research is the development of a novel separation technology for the removal of these two ions from mine wastewater to allow it to be recycled. Novel polymeric materials, known as polymer inclusion membranes (PIMs), which have nev ....The Application of Polymer Inclusion Membranes for the Removal of Thiocyanate and Cyanide from Gold Ore Processing Wastewaters. The recovery of gold at Stawell Gold Mine can be improved by using cyanide and thiocyanate free water in the milling process. The aim of this research is the development of a novel separation technology for the removal of these two ions from mine wastewater to allow it to be recycled. Novel polymeric materials, known as polymer inclusion membranes (PIMs), which have never been used before in industrial separation, will be at the centre of this technology. In addition to increasing gold recovery, this technology is expected to reduce substantially the reliance of the Australian goldmining industry on fresh water. This research will also promote PIM based separation as a viable industrial separation technology, applicable in other areas.Read moreRead less
Examining novel cell signalling in the regulation of platelet structure and function. Pharmaceutical inhibition of platelet function is the primary therapy for prevention of arterial thrombosis – the most common cause of death and disability in Australia. However, current therapies have limited efficacy. Defining platelet activation mechanisms in order to rationalise more effective antithrombotic approaches is the major focus of this research. This project describes the first studies to examine ....Examining novel cell signalling in the regulation of platelet structure and function. Pharmaceutical inhibition of platelet function is the primary therapy for prevention of arterial thrombosis – the most common cause of death and disability in Australia. However, current therapies have limited efficacy. Defining platelet activation mechanisms in order to rationalise more effective antithrombotic approaches is the major focus of this research. This project describes the first studies to examine the importance of a family of intracellular signalling enzymes, the Class II phosphoinositide 3-kinases, in platelet function. These studies will define the contribution of these enzymes to platelet production and function and will establish whether their inhibition is an attractive strategy for the prevention of arterial thrombosis.Read moreRead less