Machine Learning and Shape Optimisation of Fluid-Structure Interactions. This project aims to address vibrations of solid structures by utilising a combination of advanced experimental and computational methods. This project expects to generate new knowledge in the area of flow-induced vibrations utilising the new techniques of machine learning and evolutionary shape optimisation. Expected outcomes of this project include greatly accelerated discovery of mechanisms leading to structural vibratio ....Machine Learning and Shape Optimisation of Fluid-Structure Interactions. This project aims to address vibrations of solid structures by utilising a combination of advanced experimental and computational methods. This project expects to generate new knowledge in the area of flow-induced vibrations utilising the new techniques of machine learning and evolutionary shape optimisation. Expected outcomes of this project include greatly accelerated discovery of mechanisms leading to structural vibrations and optimising structure geometries to either enhance or suppress the vibrations. This should provide significant benefits, such as the design strategies for improved energy harvesters, such as current oscillators, or more stable structures, such as platforms for offshore wind turbines.
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Controlling coastlines while generating power. The Project aims to produce strategies for protecting coasts from storms using farms of wave-energy machines, which also generate electricity. Increasing lengths of coast need protection as the climate changes, but conventional barriers create permanent environmental impacts and are a sunk cost usually borne by the taxpayer. The Project expects to derive a strategy for the setting of each machine in the farm, so that they collectively absorb or refl ....Controlling coastlines while generating power. The Project aims to produce strategies for protecting coasts from storms using farms of wave-energy machines, which also generate electricity. Increasing lengths of coast need protection as the climate changes, but conventional barriers create permanent environmental impacts and are a sunk cost usually borne by the taxpayer. The Project expects to derive a strategy for the setting of each machine in the farm, so that they collectively absorb or reflect damaging waves under severe conditions. Under normal conditions, enough wave energy to sustain environmental processes would pass through. Sales of electricity would help to pay back the capital cost. Outcomes would include reduced coastal-erosion costs and a low-intermittency energy supply.Read moreRead less
Does Early Overnutrition Differentially Alter Hypothalamic Neuropeptides That Regulate Food Intake In The Rat
Funder
National Health and Medical Research Council
Funding Amount
$346,250.00
Summary
In Australia the incidence of obesity, in particular childhood obesity, is increasing dramatically, and the possible long term consequences of this are of great concern. The brain regulates appetite through a number of chemical transmitters such as neuropeptide Y (NPY) which is present in the brains of mammals and causes increased food intake. The effects of overeating from a young age on these brain transmitters has been largely ignored although this may impact on subsequent eating behaviour. I ....In Australia the incidence of obesity, in particular childhood obesity, is increasing dramatically, and the possible long term consequences of this are of great concern. The brain regulates appetite through a number of chemical transmitters such as neuropeptide Y (NPY) which is present in the brains of mammals and causes increased food intake. The effects of overeating from a young age on these brain transmitters has been largely ignored although this may impact on subsequent eating behaviour. In addition to NPY we will study other transmitters in the brain that have profound effects on appetite, some increasing, and others decreasing, food intake. These may form useful therapeutic targets for new drugs for obesity. Key targets we will study include melanocortins, glucagon-like peptide 1, urocortin, melanin concentrating hormone, agouti related peptide, and NPY. We will determine whether overnutrition from birth to weaning leads to changes in these appetite regulating neurotransmitters in the brain, and monitor the hormonal signals that impact on their activity. We will also determine whether early overnutrition exacerbates the subsequent responses to a high fat diet by comparison with rats made obese as adults. We will measure brain concentrations of the neurotransmitters, the amount released from the brain, and determine whether the feeding responses to injections of these agents is altered in obese animals. We have evidence that these transmitters interact in a co-ordinated fashion to affect feeding; this project will examine whether these interactions are maintained in the various types of obesity. Rats are commonly used for this type of study as the processes regulating feeding are very similar to those in humans and these agents cause similar effects in rats and humans. It is hoped that this information will provide new insight into the way brain adapts to overnutrition, and provide potential treatments for obesity and other feeding disorders.Read moreRead less
Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Numerical and experimental studies of the gas-particle flow and dust collection in electrostatic precipitation systems. This project will generate an integrated computer model to describe the gas-solid flow and dust collection in an ElectroStatic Precipitator (ESP). The model can be used to aid the design and control of ESP systems which are widely used for dust collection, leading to more competitive energy and related industries.
Advanced Combustion Modelling for Scramjets and Rotating Detonation Engines. This project will develop new fundamental knowledge and engineering models underpinning air-breathing high speed propulsion engines employing complex hydrocarbon fuels. Extensive data and new physical understanding will be garnered through analysis of direct numerical simulations of supersonic reacting mixing layers including impinging shock waves. That data will be employed to isolate, test and develop computationally ....Advanced Combustion Modelling for Scramjets and Rotating Detonation Engines. This project will develop new fundamental knowledge and engineering models underpinning air-breathing high speed propulsion engines employing complex hydrocarbon fuels. Extensive data and new physical understanding will be garnered through analysis of direct numerical simulations of supersonic reacting mixing layers including impinging shock waves. That data will be employed to isolate, test and develop computationally efficient engineering models that are accurate and efficient for high speed combustion in rotating detonation engines and scramjets. Expected outcomes are knowledge and tools needed to develop practical and effective supersonic propulsion engines for access to space, defence and high speed point-to-point flight.
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Gravity Current Driven Smoke Dispersion In a Stratified Ambient. Smoke from bushfires transported by gravity currents, and known to occur nationwide, caused the shutdown of businesses, education and events in Canberra in 2019. Recent scientific investigations have shown that the speed of propagation and concentration of smoke in these three-dimensional gravity currents have a long term ‘memory’ of their initial configuration. In this project, high-fidelity computational and experimental techniq ....Gravity Current Driven Smoke Dispersion In a Stratified Ambient. Smoke from bushfires transported by gravity currents, and known to occur nationwide, caused the shutdown of businesses, education and events in Canberra in 2019. Recent scientific investigations have shown that the speed of propagation and concentration of smoke in these three-dimensional gravity currents have a long term ‘memory’ of their initial configuration. In this project, high-fidelity computational and experimental techniques will be used to elucidate the fundamental mechanisms of gravity current entrainment and propagation. This knowledge will set a strong foundation to improve operational forecasts of smoke transport that will allow government agencies to better respond to the negative impact of these complicated flows.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
Special Research Initiatives - Grant ID: SR180100021
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
PFAS source zone remediation by foam fractionation and in situ fluidisation. This project aims to develop two methods for the in situ remediation of per- and poly-fluroalkyl substances (PFAS) contamination, downhole foam fractionation for in situ groundwater treatment, and in situ fluidisation for soil treatment, both separately and in combination. Using these methods, PFASs will be removed in the form of a foam, which will be extracted as a liquid concentrate. These techniques could enable PFAS ....PFAS source zone remediation by foam fractionation and in situ fluidisation. This project aims to develop two methods for the in situ remediation of per- and poly-fluroalkyl substances (PFAS) contamination, downhole foam fractionation for in situ groundwater treatment, and in situ fluidisation for soil treatment, both separately and in combination. Using these methods, PFASs will be removed in the form of a foam, which will be extracted as a liquid concentrate. These techniques could enable PFAS removal efficiencies of greater than 90%, providing entirely new methods for the aggressive removal of PFAS from contaminated source zones. This project will enable the rapid removal of the bulk of the PFAS present in soils and groundwater and reduce the potential for further spreading.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100042
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Next generation facility to measure microfluidic flows. Microfluidics is ubiquitous in society - for example, biofluids and engineered lab-on-a-chip platforms. This project aims to establish a novel flow measurement facility tailored for microfluidic flows with capabilities beyond current commercial flow diagnostic systems. This will enable engineers and scientists to probe the fluid dynamics of these flows with unprecedented detail to explain their underlying physical mechanisms. Beyond fluidic ....Next generation facility to measure microfluidic flows. Microfluidics is ubiquitous in society - for example, biofluids and engineered lab-on-a-chip platforms. This project aims to establish a novel flow measurement facility tailored for microfluidic flows with capabilities beyond current commercial flow diagnostic systems. This will enable engineers and scientists to probe the fluid dynamics of these flows with unprecedented detail to explain their underlying physical mechanisms. Beyond fluidic measurement, the facility provides the capacity to accurately observe micro-organisms, biological activity (cell adhesion, thrombus stability, fluorescent receptor markers), thermal collector systems (high flux, microchannel-based solar receivers), and many more mechanical phenomena at the micro-scale.
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