Harnessing sperm dynamics in microfluidic sorting technologies. Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome i ....Harnessing sperm dynamics in microfluidic sorting technologies. Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome is the next generation technology for sperm sorting and analysis. This should provide significant benefits, such as new biophysical insights into mammalian reproduction, with potential for future improvement of assisted reproduction technologies – a field in which Australia has a world leading history.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL230100023
Funder
Australian Research Council
Funding Amount
$3,362,355.00
Summary
Highly efficient microscale liquid handling and bio interfacing. The aim is to establish the exciting new field of micro elastofluidics, enabling the development of a highly competitive, sovereign capability in Australia, utilising flexibility and stretchability for efficient and precise handling of tiny volumes of liquid. The program will fill a critical gap in fundamental knowledge in fluid-structure interactions, leading to the development of wearable and implantable devices. The expected out ....Highly efficient microscale liquid handling and bio interfacing. The aim is to establish the exciting new field of micro elastofluidics, enabling the development of a highly competitive, sovereign capability in Australia, utilising flexibility and stretchability for efficient and precise handling of tiny volumes of liquid. The program will fill a critical gap in fundamental knowledge in fluid-structure interactions, leading to the development of wearable and implantable devices. The expected outcomes include innovative platform technologies for sample storage, handling and unique device-human interfaces with broad applications in health and defence. Expected benefits include enhanced capabilities in medical diagnostics, defence force protection and Australia’s sovereign high-tech manufacturing.Read moreRead less
Subsurface Atomic Force Microscopy using Dual Probes. The proposal aims to develop a new microscopy method for imaging nano-scale structures buried below the surface of a sample; for example, metal conductors in a computer processor chip. The expected outcome is a new method for creating subsurface images with an application focus on semiconductor device inspection and quality control. The proposed microscope is expected to create new economic opportunities including new commercial products, int ....Subsurface Atomic Force Microscopy using Dual Probes. The proposal aims to develop a new microscopy method for imaging nano-scale structures buried below the surface of a sample; for example, metal conductors in a computer processor chip. The expected outcome is a new method for creating subsurface images with an application focus on semiconductor device inspection and quality control. The proposed microscope is expected to create new economic opportunities including new commercial products, intellectual property, and the potential for a start-up venture. The benefits to Australia should include the creation of new job opportunities and the development of local expertise in a high-value market sector.Read moreRead less
Repetitive control systems in networked environments. Repetitive control is used in many industry applications to track periodic references and reject periodic disturbances. The development of digital technology brings in more networked control systems, greatly improving distributed manufacturing, which creates new design challenges due to network-induced constraints such as delay, data packet dropouts and cyber-attacks. This project aims to provide new understanding of dynamic behaviours of rep ....Repetitive control systems in networked environments. Repetitive control is used in many industry applications to track periodic references and reject periodic disturbances. The development of digital technology brings in more networked control systems, greatly improving distributed manufacturing, which creates new design challenges due to network-induced constraints such as delay, data packet dropouts and cyber-attacks. This project aims to provide new understanding of dynamic behaviours of repetitive control systems in networked environments, and develop a new theory for the analysis and design of networked repetitive control, subject to network induced constraints. The new control systems should reduce the cost of automation systems and will significantly enhance their performance, allowing Australian industry to remain economically competitive.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100507
Funder
Australian Research Council
Funding Amount
$444,471.00
Summary
Integrated active microcantilevers for high-throughput nanometrology. This project aims to develop a new versatile, high-performance microsensor platform and microscopy method for measuring nano-scale structures. The proposed microscopy tool is expected to significantly increase imaging speed and miniaturize system footprint, thereby enabling high-throughput quality control of semiconductor devices. The expected outcome is a highly-scalable and low-cost imaging system that will close the technol ....Integrated active microcantilevers for high-throughput nanometrology. This project aims to develop a new versatile, high-performance microsensor platform and microscopy method for measuring nano-scale structures. The proposed microscopy tool is expected to significantly increase imaging speed and miniaturize system footprint, thereby enabling high-throughput quality control of semiconductor devices. The expected outcome is a highly-scalable and low-cost imaging system that will close the technology gap between fabrication and inspection at the nanoscale. The benefits to Australia should include the potential for commercialization to develop this next-generation microscopy tool in high-value market sectors.Read moreRead less
Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and d ....Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and data storage systems. Despite its success, the technique’s spatial resolution and quantitative measurements are limited. This project could lead to breakthrough technologies such as atomic force spectroscopy to study elastic modulus of nanostructures, and establish Australia's prominence in this emerging field.Read moreRead less
Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Bet ....Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Better elemental and isotope ratio data from these high-throughput instruments will open up new real-world applications in many areas of Australian interest, such as biosecurity, forensics, groundwater management, and drug design. The research will also inform design of the next generation instruments by the industry partner.Read moreRead less