Dopamine Neuron Ontogeny: Convergent Neurobiological Pathway For Risk Factors Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$337,214.00
Summary
Schizophrenia is associated with changes in dopamine (a signalling molecule in the brain). These changes are present prior to psychosis, suggesting they begin early in development. Our aims are to manipulate key factors in the development of brain dopamine systems to clarify their role in psychosis and schizophrenia. This work has the potential to identify early brain changes that lead to schizophrenia, which in turn may generate better diagnoses and outcomes for people with this disorder.
This study investigates how much an individual's genes and environment account for the wide variation in brain structure and function. Using brain imaging we examine in what way the connectivity of the brain of identical and non-identical twins is the same or different from that of their co-twin, and carry out analysis of their DNA to identify some of the genes involved. This will provide fundamental information on genetic mechanisms influencing variation in brain structure and function.
A Prospective Study Of Language Impairment And Recovery Following Surgery For Brain Tumours
Funder
National Health and Medical Research Council
Funding Amount
$861,342.00
Summary
This multi-site project will investigate the incidence and nature of post-operative language difficulties (aphasia) in patients following surgery for left hemisphere primary brain tumours. It will provide comprehensive data concerning risk factors for post-surgical aphasia in Australian patients, in addition to important information about the brain lesions responsible for its various clinical presentations. This information will be used to generate recommendations for clinical practice.
Normal And Abnormal Development Of Brain Wiring And Its Impact On Brain Function
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
My laboratory is striving to understand how the patterns of neuronal connections form in the developing brain and how these underpin the functions of the brain throughout life. We use high-field magnetic resonance imaging to measure brain wiring and we investigate the genetic and environmental mechanisms causing developmental brain disorders that result in intellectual disability, autism, epilepsy and some mental illnesses.
Honesty and efficiency in the provision of expert services: doctors and other experts as participants in economic experiments. Experts serve us when we see the doctor, the financial planner or the car mechanic. In all these case the expert can take advantage of his superior knowledge and sell us something we do not need. This research will inform policy makers about the underlying motives of real world experts and allow them to design better institutions.
Scalability Of The Transform-Us! Program To Promote Children's Physical Activity And Reduce Prolonged Sitting In Victorian Primary Schools
Funder
National Health and Medical Research Council
Funding Amount
$549,823.00
Summary
Transform-Us! is an innovative primary school program that has been found to substantially increase children’s physical activity levels, reduce sitting time and benefit health. With simple changes to the school and classroom environments and teaching practices (eg, standing lessons) we will work with partners in the education and health systems to translate this program across Victorian primary schools to determine the real-world implementation and impact of this program over 5 years.
Advancing occupational stress research: a comprehensive trial of the Healthy Workplaces program. The project will provide a comprehensive controlled trial of an innovative stress management intervention focusing on leadership development, in one police service. Pilot results indicated significant improvements in both leader and subordinate’s health and job performance and produced economic savings.
Psychosocial influences determining Australians' sun safe practices: An examination of attitudes, norms, and control perceptions. Skin cancer accounts for approximately 80% of all new cancers diagnosed annually in Australia. As the performance of sun safe practices is dependent on individual decision-making processes, it is vital to understand the motivations underlying people's sun-protective actions. Identification of the important predictors of motivations to sun-protect will assist in develo ....Psychosocial influences determining Australians' sun safe practices: An examination of attitudes, norms, and control perceptions. Skin cancer accounts for approximately 80% of all new cancers diagnosed annually in Australia. As the performance of sun safe practices is dependent on individual decision-making processes, it is vital to understand the motivations underlying people's sun-protective actions. Identification of the important predictors of motivations to sun-protect will assist in developing specific in-class and online intervention strategies to increase people's performance of sun safety behaviours. The results of the proposed research have significant implications for reducing the incidence of non-melanoma and melanoma skin cancer and sun-related damage in a high risk context, ultimately reducing skin-cancer morbidity and mortality rates.Read moreRead less
How eating patterns interact with activity, sleep and mood. This project aims to understand temporal eating patterns (the timing and distribution of food intake and eating occasions across the day) among adults and how these eating patterns interact with activity and sleep patterns. Eating, activity and sleep patterns form a lifestyle triad which may be important for well-being and productivity. The project will study eating, activity and sleep patterns in daily life, to examine their social dri ....How eating patterns interact with activity, sleep and mood. This project aims to understand temporal eating patterns (the timing and distribution of food intake and eating occasions across the day) among adults and how these eating patterns interact with activity and sleep patterns. Eating, activity and sleep patterns form a lifestyle triad which may be important for well-being and productivity. The project will study eating, activity and sleep patterns in daily life, to examine their social drivers, interactions and effect on mood. This project could enable these behaviours to be targeted, with the potential to promote healthy lifestyles and improve health, quality of life and productivity.Read moreRead less
Enhancing the public health approach to evidence-based parenting support: efficacy of a low intensity online intervention. Child conduct problems are among the most frequently diagnosed conditions in mental health services and often lead to long-term damaging consequences. This research examines the effects of a brief online parenting intervention to help parents become more skilled in their role, leading to better child adjustment and wellbeing.